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Art. -Nr.: HY-P99940

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Biologically Validated

Remtolumab

(Synonyms: ABT-122)

Kundenbewertung

Based on 1 Customer Validation

Remtolumab is a bispecific variable domain immunoglobulin molecule with human affinities for TNFα and IL-17 in the low pM range of K_d. Remtolumab can be used in research related to rheumatoid arthritis, psoriatic arthritis, and moderate-to-severe plaque psoriasis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.24%
CAS. Nr.: 1791410-27-9
Molecular Weight:198.31 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Remtolumab Chemical Structure

CAS. Nr.: 1791410-27-9

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer

Species Reactivity

Human

IC₅₀ & Target

IL-17A

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Remtolumab (ABT-122) is the lead dual variable domain immunoglobul (DVD-Ig™) candidate selected based on its superior affinity and potency targeting human TNF and human IL-17 relative to other top candidates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Remtolumab functionally neutralizes the activities of human TNF and IL-17, and inhibits the lethal effect induced by recombinant human TNF-Dgal and the KC production induced by recombinant human IL-17 in mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

7124 [NCBI] & 3605 [NCBI]

Accession

P01375 & Q16552

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human TNF-alpha Protein can bind Remtolumab. The EC₅₀ for this effect is 2.03 ng/mL.
Immobilized Human IL-17A Protein can bind Remtolumab. The EC₅₀ for this effect is 5.32 ng/mL.

Chemical Information

CAS. Nr. 1791410-27-9
Appearance Liquid
Molecular Weight 198.31 kDa
Color Colorless to light yellow
SMILES

[Remtolumab]
Synonyms

ABT-122
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. C.-M. Hsieh, et al. FRI0303 Discovery and Characterization of Abt-122, an Anti-TNF/IL-17 Dvd-Ig™ Molecule as A Potential Therapeutic Candidate for Rheumatoid Arthritis. Annals of the Rheumatic Diseases. 2014;72(2).

[2]. Havnaer A, et al. Systemic therapies in psoriasis: an update on newly approved and pipeline biologics and oral treatments. Cutis. 2019;104(2S):17-20. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

1/16

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer
1/16

Immobilized Human TNF-alpha Protein can bind Remtolumab. The EC₅₀ for this effect is 2.03 ng/mL.
1/16

Immobilized Human IL-17A Protein can bind Remtolumab. The EC₅₀ for this effect is 5.32 ng/mL.
1/16

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Remtolumab

Protein A Agarose

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Antibody Inhibitor Library

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Remtolumab Related Classifications

HY-P99940 Related Classifications