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Art. -Nr.: HY-P1982

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Rpi-856 C

Rpi-856 C is an Aspartic protease inhibitor, with an IC₅₀ of 5.5 nM against HIV-1 protease, 9.2 nM against HTLV-I protease, 2.0 μM against Cathepsin D, and 4.8 μM against Pepsin. Rpi-856 C is produced by the Streptomyces strain AL-322. Rpi-856 C does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 C can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection.

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CAS. Nr.: 157381-55-0
Formel: C₃₉H₅₆N₆O₁₀
Molecular Weight:768.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Kundenspezifische Peptidsynthese

Rpi-856 C Chemical Structure

CAS. Nr.: 157381-55-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]^[3]

Cathepsin D

2.0 μM (IC₅₀)

HIV-1 Protease

5.5 nM (IC₅₀)

Microbial Metabolite

Alle Cathepsin Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Rpi-856 C (3 h) potently inhibits recombinant HIV-1 protease derived from Escherichia coli MM294 (DE3)/pHIV7004, with an IC₅₀ value of 5.5 nM^[1].
Rpi-856 C inhibits recombinant HTLV-I protease derived from Escherichia coli MM294 (DE3)/pHTI7707, with an IC₅₀ value of 9.2 nM^[1].
Rpi-856 C inhibits bovine cathepsin D with an IC₅₀ value of 2.0 μM^[1].
Rpi-856 C exhibits inhibitory activity against porcine pepsin, with an IC₅₀ value of 4.8 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 157381-55-0
Molecular Weight 768.90
Formel C₃₉H₅₆N₆O₁₀
Sequence

V-{Gly(2-(3,5-dihydroxyphenyl))}-L-{2-oxo-4-phenyl-3-aminobutanoyl}-VV
Sequence Shortening

Val-{Gly(2-(3,5-dihydroxyphenyl))}-Leu-{2-oxo-4-phenyl-3-aminobutanoyl}-Val-Val
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Asano T, et al. Novel retrovirus protease inhibitors, RPI-856 A, B, C and D, produced by Streptomyces sp. AL-322. J Antibiot (Tokyo). 1994 May;47(5):557-65.

[2]. Kitazaki T, et al. Synthesis and human immunodeficiency virus (HIV)-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety. Chemical & pharmaceutical bulletin. 1994 Dec;42(12):2636-40.

[3]. Huh, et al. Anti-Obesitic Effects of Cathepsin S Inhibitory Fraction Derived from Paecilomyces Tenuipes in Mice Fed a High-Fat Diet. 2009.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Rpi-856 C

Alle Cathepsin Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

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Verweise

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Help & FAQs

Rpi-856 C Related Classifications

HY-P1982 Related Classifications

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