SC-68448
SC-68448 (S 448) is a selective αvβ3 antagonist (IC50 = 1 nM). SC-68448 inhibits αvβ3-mediated endothelial cell proliferation. SC-68448 reduces the total level of αvβ6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors.
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- CAS. Nr.: 188804-07-1
- Formel: C19H19Cl2N5O4
- Molecular Weight:452.29
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Chemical Information
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CAS. Nr. 188804-07-1
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Molecular Weight 452.29
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Formel C19H19Cl2N5O4
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SMILES
O=C(O)CC(NC(CNC(C1=CC=CC(NC(N)=N)=C1)=O)=O)C2=CC(Cl)=CC(Cl)=C2
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Synonyms
S 448
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Carron CP,et al. A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res. 1998 May 1;58(9):1930-5. [Content Brief]
[2]. Roper JA, et al. Downregulation of the αvβ6 Integrin via RGD Engagement Is Affinity and Time Dependent. J Pharmacol Exp Ther. 2021 Feb;376(2):273-280. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SC-68448 Related Classifications
HY-123864 Related Classifications
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