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ML385

580 Cited Publications
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Based on 580 publication(s) in Google Scholar

ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM.

For research use only. We do not sell to patients.

  • Purity: 99.84%
  • CAS No.: 846557-71-9
  • Formula: C29H25N3O4S
  • Molecular Weight:511.59
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • ML385 Chemical Structure
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • ML385 Chemical Structure
    ML385 Chemical Structure
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
  • Experimental Validation Results for ML385
CAS No.: 846557-71-9
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  • ML385 Chemical Structure
    ML385 Chemical Structure
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    ML385 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Oct 3;35(10):1688-1703.e10. [Abstract]

    Customer Validation
     ML385 (30 mg kg−1, i.p., daily for 7 days) eliminates the differential gene expression between wild-type (WT) and Acod1−/− TINs in metastasis-bearing mice.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2019 Mar 18:2019:2853534. [Abstract]

    Customer Validation
     The protein expression levels of Nrf2 (nucleus), Nrf2 (cytoplasm), HO-1, p-NF-κB p65, NF-κB p65, and ICAM-1 proteins are analyzed by Western blot with or without the treatment of H2O2, SAA and ML385.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2019 Apr 7:2019:3501059. [Abstract]

    Customer Validation
     Western blot of Nrf2 and HO-1 protein expression levels with the treatment of HEMA, HEMA+BHQ, and HEMA+ML385.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2019 Apr 7:2019:3501059. [Abstract]

    Customer Validation
     Immunofluorescence analysis of Nrf2 expression and nuclear translocation. Green fluorescence represents Nrf2, and blue fluorescence represents nucleus of hDPCs. Data represent mean ± standard deviations (n = 3).

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Oct 24;9(1):4429.  [Abstract]

    Customer Validation
     QPCR detecting NQO1 and GCLC genes in vector or HPV16 E7-expressing HaCaT cells treated with or without 10 μM ML385 for 24 h.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2018 Oct;175(19):3747-3757. [Abstract]

    Customer Validation
     Western blot of whole liver homogenate for p-JNK and 3-NT in mice with or without Chloroquine (CQ; 60 mg/kg) at 6 h.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Sep:155:494-509. [Abstract]

    Customer Validation
     THP-1 cells are incubated with Cardamonin (30 μM), ML385 (5 μM) and ML385 + Cardamonin for 21 h, stimulated with LPS (2 μg/mL) for 3 h, and followed by ATP (5 mM) treatment for 30 min. The protein levels of NLRP3, cleaved caspase-1, ASC and cleaved IL-1β are detected by western blotting assay.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Dec 13:9:1444. [Abstract]

    Customer Validation
     Seven days after the last MPTP intoxication, nucleus, and cytosol isolated from SNpc and striatum from all groups (sham, KOK, KOK+ML385, ML385, KOK, ML385) are subjected to Western blot assay to quantify changes in Nrf2 nuclear translocation and NQO1 expression, respectively.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Dec 13:9:1444. [Abstract]

    Customer Validation
     Seven days after the last MPTP intoxication, SNpc and striatal sections (n = 3 per brain) are subjected to immunofluorescence staining using Nrf2 and NQO1 antibodies with the treatments (sham, KOK, KOK+ML385, ML385, KOK, ML385).

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Aging (Albany NY). 2018 Aug 16;10(8):2016-2036. [Abstract]

    Customer Validation
     Relative changes in the expression of Nrf2, pNrf2 and HO-1 after treatment with D-gal, ML385 alone or combined with lycopene.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Exp Gerontol. 2017 Dec 15:100:77-86. [Abstract]

    Customer Validation
     Cells are treated with ML385 at the concentration of 5 μM for 12 h. The expression of Nrf2 and its translocation into nucleus are determined using western blot analysis.

  • 1/16

    ML385 purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2017 Dec 26;1864(3):882-890. [Abstract]

    Customer Validation
     RAW264.7 cells are transfected with ML385 (5 μM) in the presence of Tan C (10 μM) for 24 h. Prdx1 and Nrf2 protein expression is determined by Western blotting

  • ML385