dHTC3
dHTC3 is a selective BRD4 molecular glue degrader. dHTC3 selectively binds to BRD4 BD1 to form a BRD4-dHTC3 complex, which cooperatively recruits the SCFFBXO3 E3 ubiquitin ligase and mediates the degradation of BRD4 via the ubiquitin-proteasome pathway. dHTC3 induces proteasome- and CRL-dependent BRD4 degradation with no hook effect. dHTC3 can be used in related research on acute myeloid leukemia.
For research use only. We do not sell to patients.
- Formula: C31H42N6O4S2
- Molecular Weight:626.83
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
BRD4 (BD1) |
In Vitro
dHTC3 does not exhibit the hook effect in both BRD4 degradation and ternary complex formation assays[1].
dHTC3 (1 nM-100 μM; 1-16 h) selectively degrades BRD4 in MV4;11, HEK293T and NALM6 cells via SCFFBXO3 mediation, and its degradation activity is completely abolished after FBXO3 knockout[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 626.83
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Formula C31H42N6O4S2
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Color Off-white to light yellow
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SMILES
O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(NS(=O)(NCC5C(CC)(CC)C5)=O)C=C4)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (159.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5953 mL | 7.9766 mL | 15.9533 mL | 39.8832 mL |
| 5 mM | 0.3191 mL | 1.5953 mL | 3.1907 mL | 7.9766 mL | |
| 10 mM | 0.1595 mL | 0.7977 mL | 1.5953 mL | 3.9883 mL | |
| 15 mM | 0.1064 mL | 0.5318 mL | 1.0636 mL | 2.6589 mL | |
| 20 mM | 0.0798 mL | 0.3988 mL | 0.7977 mL | 1.9942 mL | |
| 25 mM | 0.0638 mL | 0.3191 mL | 0.6381 mL | 1.5953 mL | |
| 30 mM | 0.0532 mL | 0.2659 mL | 0.5318 mL | 1.3294 mL | |
| 40 mM | 0.0399 mL | 0.1994 mL | 0.3988 mL | 0.9971 mL | |
| 50 mM | 0.0319 mL | 0.1595 mL | 0.3191 mL | 0.7977 mL | |
| 60 mM | 0.0266 mL | 0.1329 mL | 0.2659 mL | 0.6647 mL | |
| 80 mM | 0.0199 mL | 0.0997 mL | 0.1994 mL | 0.4985 mL | |
| 100 mM | 0.0160 mL | 0.0798 mL | 0.1595 mL | 0.3988 mL |
dHTC3 Related Classifications
HY-181976 Related Classifications
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