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Cat. No.: HY-14857

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Carotegrast

(Synonyms: HCA2969)

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Carotegrast (HCA2969) is an orally active α4 integrin inhibitor with anti-inflammatory activity. Carotegrast can be used in the research of inflammation-related diseases, such as ulcerative colitis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 98.93%
CAS No.: 401904-75-4
Formule: C₂₇H₂₄Cl₂N₄O₅
Masse moléculaire:555.41

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Carotegrast Chemical Structure

CAS No.: 401904-75-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Essai clinique
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

α4 integrin receptor^[1]

Voir tous les produits spécifiques à Isoform Integrin :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	EC₅₀	5.4 nM Compound: Carotegrast	Antagonist activity at integrin alpha4beta1 expressed in human Jurkat cells assessed as reduction in cell adhesion to human VCAM-1 incubated for 40 to 60 mins by lactate dehydrogenase assay Antagonist activity at integrin alpha4beta1 expressed in human Jurkat cells assessed as reduction in cell adhesion to human VCAM-1 incubated for 40 to 60 mins by lactate dehydrogenase assay	[PMID: 31266686]

In Vivo

Pharmacokinetic Analysis in cynomolgus monkeys treated with Vehicle or Rifampin (HY-B0272)^[2]

/	Route	Dose (mg/kg)	T_1/2 (h)	Plasma CL (mL/min/kg)	V (mL/kg)	C_max (nM)	AUC_last (h*nM)
Vehicle	i.v.	0.5	0.82	6.91	114	4717	2625
Rifampin	i.v.	0.5	1.49	0.69	45	22806	23770

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 401904-75-4
Appearance Solid
Masse moléculaire 555.41
Formule C₂₇H₂₄Cl₂N₄O₅
Color White to light yellow
SMILES

O=C(O)[C@@H](NC(C1=C(Cl)C=CC=C1Cl)=O)CC2=CC=C(N3C(N(C)C4=C(C=C(N(C)C)C=C4)C3=O)=O)C=C2
Synonyms

HCA2969
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (180.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8005 mL

9.0024 mL

18.0047 mL

5 mM

0.3601 mL

1.8005 mL

3.6009 mL

10 mM

0.1800 mL

0.9002 mL

1.8005 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kazuyuki S, et al. Preparation of novel phenylalanine derivatives as α4 integrin inhibitors. WO 2003070709 A1

[2]. Cheng Y, et al. Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys. Clin Transl Sci. 2021 Sep;14(5):1924-1934. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8005 mL	9.0024 mL	18.0047 mL	45.0118 mL
	5 mM	0.3601 mL	1.8005 mL	3.6009 mL	9.0024 mL
	10 mM	0.1800 mL	0.9002 mL	1.8005 mL	4.5012 mL
	15 mM	0.1200 mL	0.6002 mL	1.2003 mL	3.0008 mL
	20 mM	0.0900 mL	0.4501 mL	0.9002 mL	2.2506 mL
	25 mM	0.0720 mL	0.3601 mL	0.7202 mL	1.8005 mL
	30 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5004 mL
	40 mM	0.0450 mL	0.2251 mL	0.4501 mL	1.1253 mL
	50 mM	0.0360 mL	0.1800 mL	0.3601 mL	0.9002 mL
	60 mM	0.0300 mL	0.1500 mL	0.3001 mL	0.7502 mL
	80 mM	0.0225 mL	0.1125 mL	0.2251 mL	0.5626 mL
	100 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.4501 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
- Essai clinique
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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Carotegrast

Immunology/Inflammation Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Membrane Protein-targeted Compound Library

Extracellular Vesicles (EVs) Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform Integrin

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Carotegrast

Immunology/Inflammation Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Membrane Protein-targeted Compound Library

Extracellular Vesicles (EVs) Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Voir tous les produits spécifiques à Isoform Integrin

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Carotegrast Related Classifications

HY-14857 Related Classifications