Cat. No.: HY-100523

ML385

Name: ML385
Brand: MedChemExpress
SKU: HY-100523
Price: 30.00 USD
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629 Cited Publications

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ML385 is a potent and selective Nrf2 inhibitor with an IC₅₀ of 1.9 μM. ML385 directly binds to the Neh1 domain of NRF2, interferes with the binding of the MAFG-NRF2 protein complex to the antioxidant response element (ARE) DNA sequence, thereby blocking the expression of downstream target genes of NRF2. ML385 can be used in studies related to adult T-cell leukemia, breast cancer, myocardial ischemia/reperfusion injury, non-small cell lung cancer, esophageal squamous cell carcinoma, head and neck squamous cell carcinoma, and lung squamous cell carcinoma.

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Pureté: 99.84%
CAS No.: 846557-71-9
Formule: C₂₉H₂₅N₃O₄S
Masse moléculaire:511.59

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

ML385 Chemical Structure

CAS No.: 846557-71-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (629)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC50: 1.9 μM (NRF2)^[1]

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In Vitro

ML385 (1-25 μM; 12 h-7 days) reduces the expression of NRF2 and its target genes in a time- and dose-dependent manner in A549 and H460 cells, and selectively inhibits the clonogenic capacity of cells carrying KEAP1 mutations^[1].
ML385 (5 μM; 48 h) inhibits NRF2 expression, downregulates the PI3K-mTOR signaling pathway, and suppresses mTOR lysosomal recruitment in EBC1, LK2 and MGH7 cells^[2].
ML385 (5-10 μM; 24-48 h) inhibits NRF2 expression and blocks its nuclear translocation in KYSE150 and KYSE510 cells, enhances radiosensitivity, induces G2/M phase arrest, and triggers ferroptosis by increasing ROS and lipid peroxidation^[3].

ML385 (1.56-25 μM; 24-72 h) inhibits cell proliferation, induces G1-phase arrest, and triggers apoptosis and necroptosis in HTLV-1-infected T cells such as MT-2 and MT-4^[4].

ML385 (1-10 μM; 48-72 h) reduces cell viability, clonogenicity and migration capacity, and induces G1/S phase arrest in FaDu and YD9 cells^[5].
ML385 (1-50 μM; 48 h) reduces cell viability in Tamoxifen (HY-13757A)-resistant MCF-7 cells, and further promotes ferroptosis when combined with Tamoxifen^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

A549 and H460 cells
Concentration:

0.25, 0.5, 1, 2.5, 5 μM
Incubation Time:

12, 24, 48, 72 h
Result:

Dose- and time-dependently reduced intracellular NRF2 protein levels.

Real Time qPCR^[1]

Cell Line:

A549 and H460 cells
Concentration:

0.25, 0.5, 1, 2.5, 5 μM
Incubation Time:

12, 24, 48, 72 h
Result:

Dose- and time-dependently reduced the expression of NQO1 and GCLC.

Cell Proliferation Assay^[1]

Cell Line:

A549, H460, BEAS2B cells
Concentration:

0.0625, 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 25 μM
Incubation Time:

72 hours of drug exposure followed by 8-14 days of culture
Result:

Selectively inhibited the colony-forming ability of lung cancer cells with KEAP1 mutations, while showing no effect on wild-type non-tumorigenic cells.

Apoptosis Analysis^[3]

Cell Line:

KYSE150, KYSE510 cells
Concentration:

5 μM (KYSE150), 10 μM (KYSE510)
Incubation Time:

Pretreatment for 24 hours followed by ionizing radiation (IR)
Result:

Significantly increased the percentage of apoptosis cells compared to radiation alone when combined with radiation.

Cell Cycle Analysis^[3]

Cell Line:

KYSE150, KYSE510 cells
Concentration:

5 μM (KYSE150), 10 μM (KYSE510)
Incubation Time:

Pretreatment for 24 hours followed by ionizing radiation (IR)
Result:

Significantly enhanced the percentage of G2/M phase cell cycle arrest.

Cell Viability Assay^[4]

Cell Line:

MT-2, MT-4, Jurkat, PBMCs
Concentration:

1.6, 3.1, 6.3, 12.5, 25 μM
Incubation Time:

24, 48, 72 h
Result:

Dose- and time-dependently decreased the viability of HTLV-1-infected T cells, but did not affect uninfected Jurkat cells or normal PBMCs.

In Vivo

ML385 (30 mg/kg; i.p.; daily administration from Monday to Friday; 3 weeks) enhances the antitumor activity of the chemotherapeutic agent Carboplatin (HY-17393) and significantly inhibits tumor growth in a subcutaneous xenograft model of nude mice^[1].
ML385 (30 mg/kg; i.p.; daily administration from Monday to Friday; 2 weeks) enhances the anti-tumor and anti-metastatic effects of Carboplatin in an orthotopic lung tumor model^[1].
ML385 (30 mg/kg; i.p.; administered for two consecutive days prior to radiotherapy; 14 days) enhances the radiation-induced killing effect and inhibits tumor growth in a subcutaneous KYSE150 cell xenograft model in BALB/c nude mice^[3].
Combination of ML385 (30 mg/kg; i.p.; administered every other day; for 28 days) with Tamoxifen further reduces tumor volume in a subcutaneous xenograft model of MCF-7 TAMR cells in nude mice^[6].
ML385 (30 mg/kg; i.p.; single dose 15 minutes before reperfusion) abolishes melatonin (HY-B0075)-induced Nrf2 nuclear translocation and antioxidant stress protective effects in a mouse model of myocardial ischemia/reperfusion (I/R) injury^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female nude mice were injected subcutaneously with MCF-7 TAMR cells^[6]
Dosage:

30 mg/kg (co-administered with 75 mg/kg tamoxifen)
Administration:

i.p.; every other day; 28 days
Result:

Compared with the group treated with tamoxifen alone, the combination therapy group (ML385 + tamoxifen) showed significantly greater tumor shrinkage.

Animal Model:

C57BL/6 (male, 8 weeks old, 20-25 g, myocardial ischaemia/reperfusion injury model)^[7]
Dosage:

30 mg/kg
Administration:

i.p.; single dose 15 minutes prior to reperfusion (combined with melatonin)
Result:

Induced animals to exhibit a reversal of the Nrf2 nuclear translocation and an impairment of the antioxidant effects previously induced by melatonin treatment.

Animal Model:

Athymic nude mice were injected with A549 or H460 cells into the flank^[1]
Dosage:

30 mg/kg
Administration:

i.p.; daily Monday to Friday; 3 weeks
Result:

Combined carboplatin treatment significantly inhibited tumor growth.
Significantly reduced NRF2 protein levels and downstream target genes within the tumors.

Animal Model:

Athymic nude mice were injected directly with A549 or H460 cellsinto the lungs^[1]
Dosage:

30 mg/kg
Administration:

i.p.; daily Monday to Friday; 2 weeks
Result:

Compared with carboplatin monotherapy, animals treated with the combination of ML385 and carboplatin exhibited a significantly higher retention rate of tumor-free lung volume.

Animal Model:

BALB/c nude (6-week-old, specific pathogen-free, subcutaneous xenograft via injection of 2×10⁶ KYSE150 cells)^[3]
Dosage:

30 mg/kg
Administration:

i.p.; once daily; 2 consecutive days; 1followed by 8 Gy local ionizing radiation
Result:

Enhanced the radiosensitivity.

Chemical Information

CAS No. 846557-71-9
Appearance Solid
Masse moléculaire 511.59
Formule C₂₉H₂₅N₃O₄S
Color White to yellow
SMILES

O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (629)

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Journal Impact Factor

Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Nature

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. [Abstract]

2022 Oct;610(7931):366-372. PMID: 36198801
Cancer Cell

Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. [Abstract]

2021 May 10;39(5):678-693.e11. PMID: 33740421
Cell Metab

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1. [Abstract]

2023 Oct 3;35(10):1688-1703.e10. PMID: 37793345

ML385 purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Oct 3;35(10):1688-1703.e10. [Abstract]

ML385 (30 mg kg−1, i.p., daily for 7 days) eliminates the differential gene expression between wild-type (WT) and Acod1^−/− TINs in metastasis-bearing mice.
Nat Cancer

Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer. [Abstract]

2025 Jul;6(7):1263-1282. PMID: 40588523
Cell Host Microbe

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation. [Abstract]

2025 Sep 30:S1931-3128(25)00375-0. PMID: 41033313
Adv Funct Mater

2025 May 5.
Autophagy

Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis. [Abstract]

2025 Feb;21(2):407-423. PMID: 39291751
Nat Commun

Targeting fatty acid oxidation enhances response to HER2-targeted therapy. [Abstract]

2024 Aug 3;15(1):6587. PMID: 39097623
Nat Commun

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth. [Abstract]

2018 Oct 24;9(1):4429. PMID: 30356100

ML385 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Oct 24;9(1):4429. [Abstract]

QPCR detecting NQO1 and GCLC genes in vector or HPV16 E7-expressing HaCaT cells treated with or without 10 μM ML385 for 24 h.
Exp Mol Med

Machine learning-based integration of transcriptome and digital pathology for predicting chemoresistance in muscle-invasive bladder cancer. [Abstract]

2026 May;58(5):1589-1607. PMID: 42104016
Exp Mol Med

TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway. [Abstract]

2021 Sep;53(9):1307-1318. PMID: 34497345
ACS Nano

A Blood-Triggered Adhesive Hydrogel Loaded with Reactive Oxygen Species-Responsive Liposomes for the Treatment of Acute Kidney Injury. [Abstract]

2026 May 5;20(17):12859-12877. PMID: 42018446
J Adv Res

4-Octyl itaconate-induced Nrf2 nuclear translocation mitigates Caspase-11-dependent noncanonical macrophage pyroptosis and acute lung injury. [Abstract]

2026 May 4:S2090-1232(26)00378-4. PMID: 42092588
J Adv Res

Nrf2 deficiency in myeloid cells accelerates atherosclerosis by promoting the inflammatory response and impairing efferocytosis. [Abstract]

2026 Jan 2:S2090-1232(26)00005-6. PMID: 41485574
J Adv Res

MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis. [Abstract]

2025 Oct 10:S2090-1232(25)00764-7. PMID: 41077348
Metabolism

Acacetin ameliorates MASLD by inhibiting the Notch1 pathway in hepatocytes and reprogramming macrophage polarization via Keap1-Nrf2-mediated restraint of ferroptosis. [Abstract]

2026 Jun 7:182:156670. PMID: 42259496
Metabolism

1,25-Dihydroxyvitamin D3 protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia. [Abstract]

2025 Jan:162:156058. PMID: 39488297
Sci Immunol

Citraconate preserves T cell stemness and antitumor immunity. [Abstract]

2026 May;11(119):eadz0348. PMID: 42066062
Redox Biol

ACOD1-itaconate in macrophage attenuates oxidative stress and inflammation in benign airway stenosis by upregulating and transferring FTH1. [Abstract]

2026 May:92:104133. PMID: 41865719
Redox Biol

YAP/Nrf2 suppresses ferroptosis to alleviate acute lung injury induced by intestinal ischemia/reperfusion. [Abstract]

2025 Oct:86:103811. PMID: 40763655
Redox Biol

Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation. [Abstract]

2025 Oct:86:103803. PMID: 40784044
Redox Biol

Nrf2/Nlrp3 signaling in aging BMSCs: Traf6 intervention as a novel approach to osteoporosis treatment. [Abstract]

2025 Oct:86:103804. PMID: 40768898
Redox Biol

Injectable ROS homeostasis protective hydrogel inhibiting microglial ferroptosis through the Nrf2/Slc7a11/Gpx4 to alleviate neuropathic pain and promote spinal cord injury repair. [Abstract]

2025 Oct:86:103816. PMID: 40795617
Redox Biol

Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis. [Abstract]

2025 Feb:79:103482. PMID: 39736200
Redox Biol

MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction. [Abstract]

2024 Feb:69:102987. PMID: 38100883
Redox Biol

Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2/HO-1 pathway in MCAO mice. [Abstract]

2023 Oct:66:102852. PMID: 37598463
Redox Biol

EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis. [Abstract]

2023 Jul:63:102765. PMID: 37269686
Redox Biol

MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling. [Abstract]

2023 Jun:62:102706. PMID: 37098317
Redox Biol

Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages. [Abstract]

2023 Feb:59:102591. PMID: 36574745
Redox Biol

Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis. [Abstract]

2021 Jan:38:101771. PMID: 33189984
Cardiovasc Diabetol

Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment. [Abstract]

2024 May 3;23(1):150. PMID: 38702777
J Nanobiotechnology

Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke. [Abstract]

2025 Jul 5;23(1):488. PMID: 40618146
J Nanobiotechnology

Brain-targeted ursolic acid nanoparticles for anti-ferroptosis therapy in subarachnoid hemorrhage. [Abstract]

2024 Oct 18;22(1):641. PMID: 39425081
Theranostics

Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury. [Abstract]

2025 Jan 20;15(6):2360-2374. PMID: 39990234
Theranostics

Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice. [Abstract]

2019 Aug 14;9(20):5956-5975. PMID: 31534531
Acta Pharm Sin B

Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma. [Abstract]

2021 May;11(5):1246-1260. PMID: 34094831
J Exp Clin Cancer Res

Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3η/NF-κB feedback loop. [Abstract]

2018 Dec 20;37(1):321. PMID: 30572915
Adv Sci (Weinh)

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis. [Abstract]

2026 Jun;13(34):e23189. PMID: 41933938
Adv Sci (Weinh)

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke. [Abstract]

2025 Nov 6:e07384. PMID: 41195589
Adv Sci (Weinh)

Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis. [Abstract]

2025 Apr;12(15):e2408763. PMID: 39985288
MedComm (2020)

Dimethyl fumarate alleviate hepatic ischemia-reperfusion injury through suppressing cGAS-STING signaling. [Abstract]

2025 Jan 28;6(2):e70077. PMID: 39877286
MedComm

Pyrogallol protects against influenza A virus-triggered lethal lung injury by activating the Nrf2-PPAR-γ-HO-1 signaling axis. [Abstract]

2024 Apr 12;5(4):e531. PMID: 38617435
Adv Sci (Weinh)

A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy. [Abstract]

2024 Apr;11(14):e2307143. PMID: 38308097
MedComm

Nrf2/PHB2 alleviates mitochondrial damage and protects against Staphylococcus aureus-induced acute lung injury. [Abstract]

2023 Dec 7;4(6):e448. PMID: 38077250
Cell Death Differ

Itaconate protects ferroptotic neurons by alkylating GPx4 post stroke. [Abstract]

2024 Aug;31(8):983-998. PMID: 38719928
Biomaterials

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. [Abstract]

2020 Oct:257:120264. PMID: 32791387
Chem Eng J

2025 Sep 27;524:168995.
J Control Release

Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury. [Abstract]

2022 May;345:214-230. PMID: 35307508
Cell Death Dis

PEBP4 alleviates muscle wasting in lung cancer cachexia via KEAP1-NRF2-mediated redox homeostasis. [Abstract]

2026 Jun 3. PMID: 42236665
Cell Death Dis

USP33 alleviates FIS1-dependent mitochondrial fission and cardiac microvascular injury in diabetic cardiomyopathy via deubiquitinating and stabilizing ATG7. [Abstract]

2026 May 30. PMID: 42218158
Cell Death Dis

ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease. [Abstract]

2025 Apr 9;16(1):266. PMID: 40204709
Cell Death Dis

MTCH2 regulates NRF2-mediated RRM1 expression to promote melanoma proliferation and dacarbazine insensitivity. [Abstract]

2025 Apr 9;16(1):268. PMID: 40204724
Pharmacol Res

PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. [Abstract]

2023 Feb:188:106666. PMID: 36657504
Pharmacol Res

Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury. [Abstract]

2023 Jan:187:106563. PMID: 36410674
Cell Death Dis

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway. [Abstract]

2021 May 18;12(6):504. PMID: 34006826
Cell Death Dis

ω-6 Polyunsaturated fatty acids (linoleic acid) activate both autophagy and antioxidation in a synergistic feedback loop via TOR-dependent and TOR-independent signaling pathways. [Abstract]

2020 Jul 30;11(7):607. PMID: 32732901
Cancer Lett

Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer. [Abstract]

2022 Nov 28:549:215915. PMID: 36113636
J Immunother Cancer

Targeted inhibition of Nrf2 potentiates antitumor immunity and enhances the efficacy of immunotherapy in hepatocellular carcinoma. [Abstract]

2026 Mar 24;14(3):e010841. PMID: 41876134
Int J Biol Sci

Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis. [Abstract]

2025 Apr 28;21(7):3247-3261. PMID: 40384872
Int J Biol Sci

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis. [Abstract]

2022 Oct 24;18(16):6189-6209. PMID: 36439878
Int J Biol Sci

Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway. [Abstract]

2020 Jan 1;16(1):12-26. PMID: 31892842
Cell Commun Signal

IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury. [Abstract]

2025 Feb 5;23(1):63. PMID: 39910615
J Neuroinflammation

Repurposing of epalrestat for neuroprotection in parkinson's disease via activation of the KEAP1/Nrf2 pathway. [Abstract]

2025 Apr 29;22(1):125. PMID: 40301912
Phytomedicine

Oxymatrine alleviates cerebral ischemia-reperfusion injury by inhibiting microglia ferroptosis via NRF2 pathway activation. [Abstract]

2026 Jun 17:159:158450. PMID: 42322761
Phytomedicine

Total glycosides of Cistanche deserticola ameliorate alcohol-induced oligoasthenozoospermia via the modulation of gut microbiota-mediated spermidine metabolism. [Abstract]

2026 Jun 23. PMID: 42372605
Phytomedicine

Indole-3-carbinol attenuates cisplatin-induced premature ovarian failure by activating Nrf2 through competitive binding of Keap1. [Abstract]

2026 May:154:158040. PMID: 41818942
Phytomedicine

Schisandrin B alleviates liver allograft rejection by stabilizing ACOD1 in Kupffer cells to potentiate itaconate-NRF2-mediated suppression of CD8+ T cell chemotaxis. [Abstract]

2026 May:154:158031. PMID: 41795300
Phytomedicine

Dihydroartemisinin inhibits galectin-1-induced ferroptosis resistance and peritoneal metastasis of gastric cancer via the Nrf2-HO-1 pathway. [Abstract]

2025 Nov 25:148:157416. PMID: 41166905
Phytomedicine

Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporosis by inhibiting ferroptosis through the Nrf2/GPX4/SLC7A11 pathway. [Abstract]

2025 Sep 23:148:157319. PMID: 41016294
Phytomedicine

Ginsenoside Rg5 ameliorates lipopolysaccharide (LPS)-induced acute liver injury via interfering Autophagy/Nrf2/Ferroptosis signal axis. [Abstract]

2025 Aug:144:156941. PMID: 40516288
Phytomedicine

Linarin attenuates hyperuricemic nephropathy by modulating Nrf2/Keap1 and TLR4/NF-κB signaling pathways: Linarin attenuates hyperuricemic nephropathy. [Abstract]

2025 Apr:139:156440. PMID: 39908585
Phytomedicine

Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway. [Abstract]

2025 Mar:138:156389. PMID: 39827815
Phytomedicine

Stigmasterol from Prunella vulgaris L. Alleviates LPS-induced mammary gland injury by inhibiting inflammation and ferroptosis. [Abstract]

2025 Feb:137:156362. PMID: 39809030
Phytomedicine

Forsythoside A mitigates osteoarthritis and inhibits chondrocyte senescence by promoting mitophagy and suppressing NLRP3 inflammasome via the Nrf2 pathway. [Abstract]

2024 Dec:135:156052. PMID: 39383631
Phytomedicine

Esculin inhibits hepatic stellate cell activation and CCl4-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway. [Abstract]

2024 Jun:128:155465. PMID: 38471319
Phytomedicine

Grape seed-derived procyanidin inhibits glyphosate-induced hepatocyte ferroptosis via enhancing crosstalk between Nrf2 and FGF12. [Abstract]

2024 Jan:123:155278. PMID: 38103315
Phytomedicine

Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice. [Abstract]

2023 Sep:118:154962. PMID: 37506403
Phytomedicine

Effect of allyl isothiocyanate on oxidative stress in COPD via the AhR / CYP1A1 and Nrf2 / NQO1 pathways and the underlying mechanism. [Abstract]

2023 Jun:114:154774. PMID: 36996530
Phytomedicine

Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice. [Abstract]

2023 May:113:154725. PMID: 36867963
Phytomedicine

Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners. [Abstract]

2023 Feb 24;113:154726. PMID: 36863308
Phytomedicine

Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics. [Abstract]

2023 Jan:108:154495. PMID: 36257219
Phytomedicine

Isoliquiritigenin mitigates oxidative damage after subarachnoid hemorrhage in vivo and in vitro by regulating Nrf2-dependent Signaling Pathway via Targeting of SIRT1. [Abstract]

2022 Oct:105:154262. PMID: 35896045
Phytomedicine

Spatholobi Caulis dispensing granule reduces deep vein thrombus burden through antiinflammation via SIRT1 and Nrf2. [Abstract]

2020 Oct:77:153285. PMID: 32707369
Phytomedicine

4,5-di-O-caffeoylquinic acid methyl ester isolated from Lonicera japonica Thunb. targets the Keap1/Nrf2 pathway to attenuate H2O2-induced liver oxidative damage in HepG2 cells. [Abstract]

2020 Apr 15:70:153219. PMID: 32361557
EBioMedicine

Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. [Abstract]

2021 Jul;69:103456. PMID: 34233258
Mater Today Bio

A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation. [Abstract]

2025 Dec 6:36:102627. PMID: 41488425
Adv Healthc Mater

Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Combined with PEG Hydrogel Alleviate Maternal Simulated Birth Injury in a Rat Model. [Abstract]

2025 Aug;14(20):e2405259. PMID: 40237194
J Renin Angiotensin Aldosterone Syst

2025 Jun 30.
Acta Biomater

Gallium-doped mesoporous bioactive glass nanoparticles for antibacterial and immunomodulatory effects in vital pulp therapy. [Abstract]

2026 May:215:228-244. PMID: 41871676
Acta Pharmacol Sin

Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis. [Abstract]

2025 Jan;46(1):81-95. PMID: 39143234
Acta Pharmacol Sin

CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy. [Abstract]

2022 Jul;43(7):1793-1802. PMID: 34754093
Cell Death Discov

microRNA-140-3p protects hippocampal neuron against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting DNMT1. [Abstract]

2022 Jun 16;8(1):290. PMID: 35710537
Acta Pharmacol Sin

Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway. [Abstract]

2021 Dec;42(12):2069-2081. PMID: 34417573
Acta Pharmacol Sin

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress. [Abstract]

2021 Mar;42(3):347-360. PMID: 33462377
NPJ Precis Oncol

Targeting Nrf2/PHKG2 axis to enhance radiosensitivity in NSCLC. [Abstract]

2024 Aug 21;8(1):183. PMID: 39169204
J Transl Med

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway. [Abstract]

2021 Mar 2;19(1):96. PMID: 33653364
J Environ Manage

Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway. [Abstract]

2024 Dec:371:123235. PMID: 39509968
Osteoarthritis Cartilage

DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy. [Abstract]

2024 Aug;32(8):921-937. PMID: 38719085
Oncogene

CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis. [Abstract]

2025 Jun;44(22):1678-1693. PMID: 40089640
Int J Nanomedicine

GLX351322-Loaded Nanoparticles Alleviate Chronic Stress-Induced Depressive Behaviors Through Inhibition of Ferroptosis and Oxidative Stress. [Abstract]

2025 Nov 24:20:14033-14055. PMID: 41321900
Regen Biomater

Injectable exosome-reinforced konjac glucomannan composite hydrogel for repairing cartilage defect: activation of endogenous antioxidant pathways. [Abstract]

2025 Jun 17:12:rbaf060. PMID: 40747331
Int J Biol Macromol

Carboxymethyl Poria cocos polysaccharides protect against septic kidney injury by regulating the Nrf2-NF-κB signaling pathway. [Abstract]

2025 May;308(Pt 3):143030. PMID: 40216133
Int J Biol Macromol

Bacillus amyloliquefaciens SC06 alleviates LPS-induced intestinal damage by inhibiting endoplasmic reticulum stress and mitochondrial dysfunction in piglets. [Abstract]

2024 Nov 5;282(Pt 6):137307. PMID: 39510464
Int J Biol Macromol

MiR-221 on protective oxidative induced by selenium modified Codonopsis pilosula polysaccharide. [Abstract]

2024 Nov;279(Pt 3):134815. PMID: 39154690
Int J Biol Macromol

Sufentanil-induced Nrf2 protein ameliorates cerebral ischemia-reperfusion injury through suppressing neural ferroptosis. [Abstract]

2024 Nov;279(Pt 1):135109. PMID: 39197624
Int J Biol Macromol

Chitosan oligosaccharides alleviate macrophage pyroptosis and protect sepsis mice via activating the Nrf2/GPX4 pathway. [Abstract]

2024 Oct;277(Pt 1):133899. PMID: 39019361
J Headache Pain

Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation. [Abstract]

2024 Apr 2;25(1):50. PMID: 38565987
Int J Biol Macromol

Glucomannan from Aloe vera gel maintains intestinal barrier integrity via mitigating anoikis mediated by Nrf2-mitochondria axis. [Abstract]

2023 Apr 30:235:123803. PMID: 36841393
Int J Biol Macromol

Lentinan inhibits oxidative stress and alleviates LPS-induced inflammation and apoptosis of BMECs by activating the Nrf2 signaling pathway. [Abstract]

2022 Dec 1;222(Pt B):2375-2391. PMID: 36243161
Int J Biol Macromol

Microwave assisted extraction, characterization of a polysaccharide from Salvia miltiorrhiza Bunge and its antioxidant effects via ferroptosis-mediated activation of the Nrf2/HO-1 pathway. [Abstract]

2022 Aug 31:215:398-412. PMID: 35718160
Int J Nanomedicine

Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect. [Abstract]

2018 May 17:13:2907-2919. PMID: 29844673
Int J Mol Med

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice. [Abstract]

2026 Jan;57(1):26. PMID: 41268602
Int J Mol Med

Ultrasound‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction. [Abstract]

2024 Jun;53(6):54. PMID: 38666537
Int J Mol Med

Dihydroartemisinin attenuates lipopolysaccharide‑induced acute lung injury in mice by suppressing NF‑κB signaling in an Nrf2‑dependent manner. [Abstract]

2019 Dec;44(6):2213-2222. PMID: 31661121
Mol Med

Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy. [Abstract]

2025 Jul 24;31(1):264. PMID: 40702453
Mol Med

VILIP3 attenuates neuronal apoptosis and oxidative stress via Nrf2 activation in the pathogenesis of Alzheimer's disease. [Abstract]

2025 Jun 10;31(1):227. PMID: 40495165
Mol Med

TWEAK/Fn14 disrupts Th17/Treg balance and aggravates conjunctivitis by inhibiting the Nrf2/HO-1 pathway in allergic conjunctivitis mice. [Abstract]

2024 Nov 26;30(1):233. PMID: 39592944
Mater Des

2026 Mar 18.
Antioxidants (Basel)

Pterostilbene Promotes Spinal Cord Injury Recovery by Inhibiting Ferroptosis via Keap1/Nrf2/SLC7A11/GPX4 Axis Activation. [Abstract]

2026 Feb 2;15(2):188. PMID: 41750570
Antioxidants (Basel)

Aspirin Eugenol Ester Alleviates Gastric Injury by Inhibiting Ferroptosis and Oxidative Stress. [Abstract]

2026 Feb 9;15(2):225. PMID: 41750606
Antioxidants (Basel)

Betaine Inhibits Ferroptosis After Intracerebral Hemorrhage by Activating the Nrf2/HO-1 Pathway. [Abstract]

2026 Jan 21;15(1):135. PMID: 41596193
Antioxidants (Basel)

2025 Dec 19;15(1):2.
Antioxidants

Study on the Regulatory Effect of Water Extract of Artemisia annua L. on Antioxidant Function of Mutton Sheep via the Keap1/Nrf2 Signaling Pathway. [Abstract]

2025 Jul 18;14(7):885. PMID: 40722989
Antioxidants (Basel)

Eleutheroside B Ameliorates Cardiomyocytes Necroptosis in High-Altitude-Induced Myocardial Injury via Nrf2/HO-1 Signaling Pathway. [Abstract]

2025 Feb 7;14(2):190. PMID: 40002377
Antioxidants

Carnosine Synthase (Ts ATPGD) Alleviates Lipid Peroxidation Under Transcriptional Control by an Nfe2-like Gene in Tridacna Squamosa. [Abstract]

2024 Nov 4;13(11):1351. PMID: 39594493
Antioxidants (Basel)

Artemisia Ordosica Polysaccharides Enhance Antioxidant Capacity of Peripheral Blood Lymphocytes in Poultry Through Nrf2/Keap1 and TLR4/NF-κB Signal Pathway. [Abstract]

2024 Oct 28;13(11):1308. PMID: 39594450
Antioxidants (Basel)

Tamarixetin Protects Chondrocytes against IL-1β-Induced Osteoarthritis Phenotype by Inhibiting NF-κB and Activating Nrf2 Signaling. [Abstract]

2024 Sep 25;13(10):1166. PMID: 39456419
Antioxidants (Basel)

Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress. [Abstract]

2024 Jul 26;13(8):904. PMID: 39199151
Antioxidants (Basel)

Alginate Oligosaccharides Protect Gastric Epithelial Cells against Oxidative Stress Damage through Induction of the Nrf2 Pathway. [Abstract]

2024 May 20;13(5):618. PMID: 38790723
Antioxidants (Basel)

γ-Glutamylcysteine Exerts Neuroprotection Effects against Cerebral Ischemia/Reperfusion Injury through Inhibiting Lipid Peroxidation and Ferroptosis. [Abstract]

2022 Aug 25;11(9):1653. PMID: 36139727
Antioxidants (Basel)

Melatonin Nuclear Receptors Mediate Green-and-Blue-Monochromatic-Light-Combinations-Inhibited B Lymphocyte Apoptosis in the Bursa of Chickens via Reducing Oxidative Stress and Nfκb Expression. [Abstract]

2022 Apr 8;11(4):748. PMID: 35453433
Phytother Res

Epigallocatechin-3-Gallate (EGCG) Mitigates Deep Vein Thrombosis Through Antioxidant and Anti-Ferroptotic Actions via the NRF2-NEDD4 Pathway. [Abstract]

2026 Jun;40(6):3668-3687. PMID: 41947351
Phytother Res

Galangin attenuates doxorubicin-induced cardiotoxicity via activating nuclear factor erythroid 2-related factor 2/heme oxygenase 1 signaling pathway to suppress oxidative stress and inflammation. [Abstract]

2023 Dec;37(12):5854-5870. PMID: 37655750
Free Radic Biol Med

BHLHE40 drives ferroptosis in Escherichia coli-induced endometrial injury by recruiting HDAC1 to repress CPT1B and impair NRF2 signaling. [Abstract]

2026 May 12:252:509-524. PMID: 42128070
Free Radic Biol Med

The MafG/Bach1-Lcn2 transcriptional axis drives ferroptosis in sepsis-induced acute lung injury via disrupting redox homeostasis. [Abstract]

2025 Dec 29:245:250-268. PMID: 41475687
Free Radic Biol Med

Inhibition of MAGL ameliorates glucocorticoid-induced bone loss by regulating the Nrf2 signaling. [Abstract]

2025 Nov 14:243:67-81. PMID: 41242471
Free Radic Biol Med

2025 Oct 24.
Free Radic Biol Med

7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression. [Abstract]

2025 Oct 30:242:275-287. PMID: 41173313
Free Radic Biol Med

HDAC inhibition protects RPE cells from oxidative stress via enhanced mitochondrial fusion, cytoskeletal repair, and Nrf-2 activation. [Abstract]

2025 Aug 13:240:59-70. PMID: 40816649
Free Radic Biol Med

Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway. [Abstract]

2025 Aug 11:240:238-252. PMID: 40803417
Free Radic Biol Med

Exogenous Maresin1 attenuates doxorubicin-induced cardiomyocyte ferroptosis and mitochondrial impairment via NRF2/GPX4 axis. [Abstract]

2025 Aug 1:235:335-346. PMID: 40348287
Free Radic Biol Med

MOTS-c mimics remote ischemic preconditioning in protecting against lung ischemia-reperfusion injury by alleviating endothelial barrier dysfunction. [Abstract]

2025 Mar 1:229:127-138. PMID: 39827923
Free Radic Biol Med

Nrf2 ameliorates defective autophagic processes and thereby inhibits ferroptosis in acute pancreatitis by suppressing Beclin1-Slc7a11 complex formation. [Abstract]

2025 Mar 16:230:294-308. PMID: 39947493
Free Radic Biol Med

Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats. [Abstract]

2025 Feb 1:227:472-484. PMID: 39647799
Free Radic Biol Med

Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression. [Abstract]

2024 Sep:222:229-243. PMID: 38906233
Free Radic Biol Med

Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice. [Abstract]

2024 May 9:221:1-12. PMID: 38734270
Free Radic Biol Med

Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion. [Abstract]

2024 Mar:214:115-128. PMID: 38331008
Free Radic Biol Med

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]

2024 Mar:213:150-163. PMID: 38190923
Free Radic Biol Med

Dopamine D1 receptor agonist alleviates acute lung injury via modulating inflammatory responses in macrophages and barrier function in airway epithelial cells. [Abstract]

2023 Jun:202:2-16. PMID: 36965538
Free Radic Biol Med

Endogenous production of ω-3 polyunsaturated fatty acids mitigates cisplatin-induced myelosuppression by regulating NRF2-MDM2-p53 signaling pathway. [Abstract]

2023 May 20:201:14-25. PMID: 36906190
Free Radic Biol Med

Caspase-8 mutants activate Nrf2 via phosphorylating SQSTM1 to protect against oxidative stress in esophageal squamous cell carcinoma. [Abstract]

2022 Nov 1:192:51-62. PMID: 36165926
Free Radic Biol Med

Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways. [Abstract]

2022 Mar:182:108-118. PMID: 35231555
Free Radic Biol Med

Iso-seco-tanapartholide activates Nrf2 signaling pathway through Keap1 modification and oligomerization to exert anti-inflammatory effects. [Abstract]

2022 Jan:178:398-412. PMID: 34923099
Free Radic Biol Med

Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages. [Abstract]

2022 Jan:178:42-53. PMID: 34848368
Free Radic Biol Med

Mitoquinone attenuates vascular calcification by suppressing oxidative stress and reducing apoptosis of vascular smooth muscle cells via the Keap1/Nrf2 pathway. [Abstract]

2020 Dec:161:23-31. PMID: 33011276
Free Radic Biol Med

Protective effect of dihydroartemisinin in inhibiting senescence of myeloid-derived suppressor cells from lupus mice via Nrf2/HO-1 pathway. [Abstract]

2019 Nov 1:143:260-274. PMID: 31419476
Free Radic Biol Med

Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress. [Abstract]

2019 Apr:134:23-41. PMID: 30599260
J Anim Sci Biotechnol

The ameliorative role of phlorotannin on aflatoxin B1-induced liver oxidative stress and mitochondrial injury is related to the activation of Nrf2 and Nrf1 signaling pathways in broilers. [Abstract]

2025 May 22;16(1):75. PMID: 40405298
J Anim Sci Biotechnol

Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway. [Abstract]

2023 Apr 10;14(1):56. PMID: 37032323
ACS Appl Mater Interfaces

Microneedle Patch Delivering Multifunctional Melanin-like Nanoparticles for Vitiligo Remission and Repigmentation. [Abstract]

2025 Dec 24;17(51):68894-68909. PMID: 41370668
Am J Chin Med

Electroacupuncture Preconditioning Attenuates Myocardial Ischemia-Reperfusion Injury in Rats Partially Through Nrf2-Mediated Reduction of Oxidative Stress and Pyroptosis. [Abstract]

2025;53(2):337-352. PMID: 40107884
Am J Chin Med

Panax notoginseng Saponins Activate Nuclear Factor Erythroid 2-Related Factor 2 to Inhibit Ferroptosis and Attenuate Inflammatory Injury in Cerebral Ischemia-Reperfusion. [Abstract]

2024;52(3):821-839. PMID: 38699996
Am J Chin Med

Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways. [Abstract]

2023;51(4):929-951. PMID: 36974993
Am J Chin Med

Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol. [Abstract]

2022;50(8):2103-2123. PMID: 36309811
Stem Cell Res Ther

hPMSCs inhibit the expression of PD-1 in CD4+IL-10+ T cells and mitigate liver damage in a GVHD mouse model by regulating the crosstalk between Nrf2 and NF-κB signaling pathway. [Abstract]

2021 Jun 29;12(1):368. PMID: 34187557
Am J Chin Med

Salvia miltiorrhiza Restrains Reactive Oxygen Species-Associated Pulmonary Fibrosis via Targeting Nrf2-Nox4 Redox Balance. [Abstract]

2019;47(5):1113-1131. PMID: 31352786
Aging Cell

Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence. [Abstract]

2021 Oct;20(10):e13483. PMID: 34587364
J Pineal Res

Melatonin Improves Diabetic-Accelerated Experimental Osteoarthritis by Inhibiting NLRP3-Mediated Chondrocyte Pyroptosis via PKG/Nrf2. [Abstract]

2026 Mar;78(2):e70113. PMID: 41704066
Br J Pharmacol

Quercetin alleviates postmenopausal atherosclerosis by suppressing endothelial cell ferroptosis via regulating the KEAP1/NRF2/GPX4 signalling pathway. [Abstract]

2025 Oct 8. PMID: 41063334
Br J Pharmacol

Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1-mediated autophagy. [Abstract]

2025 Jun;182(12):2730-2753. PMID: 40052261
Br J Pharmacol

Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy. [Abstract]

2018 Oct;175(19):3747-3757. PMID: 30024038

ML385 purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2018 Oct;175(19):3747-3757. [Abstract]

Western blot of whole liver homogenate for p-JNK and 3-NT in mice with or without Chloroquine (CQ; 60 mg/kg) at 6 h.
Neurotherapeutics

Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway. [Abstract]

2024 Sep;21(5):e00444. PMID: 39353831
Environ Health

2025 Nov 28，XXXX(XXX).
Clin Sci

Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis. [Abstract]

2025 Feb 6;139(3):229-246. PMID: 39866066
Environ Pollut

Methylmercury induced ferroptosis by interference of iron homeostasis and glutathione metabolism in CTX cells. [Abstract]

2023 Oct 15:335:122278. PMID: 37517642
Environ Pollut

linc01515 regulates PM2.5-induced oxidative stress via targeting NRF2 in airway epithelial cells. [Abstract]

2023 Aug 15;331(Pt 2):121798. PMID: 37169236
J Invest Dermatol

Trehalose Prevents IL-4/IL-13-Induced Skin Barrier Impairment by Suppressing IL-33 Expression and Increasing NRF2 Activation in Human Keratinocytes In Vitro. [Abstract]

2025 Jun;145(6):1422-1432.e10. PMID: 39384017
Front Immunol

LPS Stimulation Induces Small Heterodimer Partner Expression Through the AMPK-NRF2 Pathway in Large Yellow Croaker (Larimichthys crocea). [Abstract]

2021 Nov 8:12:753681. PMID: 34819934
Front Immunol

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling. [Abstract]

2020 Dec 9:11:593368. PMID: 33362775
Redox Rep

Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathway. [Abstract]

2026 Dec 31;31(1):2668238. PMID: 42241031
Redox Rep

Activation of the Nrf2/Keap1 signaling pathway mediates the neuroprotective effect of Perillyl alcohol against cerebral hypoxic-ischemic damage in neonatal rats. [Abstract]

2024 Dec;29(1):2394714. PMID: 39284589
J Ethnopharmacol

Ginsenoside Rg1 attenuates PM2.5-induced neurotoxicity by suppressing ferroptosis via the Nrf2/GPx4 axis. [Abstract]

2026 May 23:363:121464. PMID: 41775233
J Ethnopharmacol

Shen-Shuai-II-Recipe suppresses hypoxia-induced oxidative stress and ferroptosis via Nrf2 activation to ameliorate renal fibrosis in chronic kidney disease. [Abstract]

2026 Feb 10:356:120783. PMID: 41139039
J Ethnopharmacol

Sesamin promotes the survival of skin flaps in rats by inhibiting ferroptosis through the Nrf2/SLC7A11/GPX4 signaling pathway. [Abstract]

2026 Feb 28:357:120938. PMID: 41275941
Antioxid Redox Signal

Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage. [Abstract]

2025 Dec 26. PMID: 41468154
J Ethnopharmacol

Sappanone A alleviates high glucose-induced retinal oxidative injury and mitochondrial dysfunction via SIRT7/NRF2 pathway. [Abstract]

2025 Oct 22:120774. PMID: 41135616
J Ethnopharmacol

Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis. [Abstract]

2025 Aug 17;353(Pt B):120441. PMID: 40829693
J Ethnopharmacol

Hu Gan Tang ameliorates metabolic-associated fatty liver disease by inhibiting ferroptosis through the Nrf2/GPX4 pathway. [Abstract]

2025 Jul 31;353(Pt A):120342. PMID: 40752599
Antioxid Redox Signal

Uric Acid Stimulates PINK1/Parkin-Mediated Mitophagy via Nrf2/HO-1 Pathway to Protect Against Neuronal Apoptosis in Alzheimer's Disease. [Abstract]

2025 Jun 27. PMID: 40576628
J Ethnopharmacol

Lycii Fructus and Chrysanthemum Flos, a Chinese medicine herbal pair, ameliorates retinal degeneration of mice induced by sodium iodate and protects Müller cells from oxidative stress. [Abstract]

2025 May 12:347:119747. PMID: 40204251
J Ethnopharmacol

Zuogui Pills alleviate cyclophosphamide-induced ovarian aging by reducing oxidative stress and restoring the stemness of oogonial stem cells through the Nrf2/HO-1 signaling pathway. [Abstract]

2024 Oct 28:333:118505. PMID: 38945466
Antioxid Redox Signal

Intervention of asprosin attenuates oxidative stress and neointima formation in vascular injury. [Abstract]

2024 Sep;41(7-9):488-504. PMID: 38814824
J Ethnopharmacol

Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway. [Abstract]

2024 Aug 10:330:118205. PMID: 38641079
J Ethnopharmacol

Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells. [Abstract]

2024 Apr 24:324:117794. PMID: 38244950
J Ethnopharmacol

Polysaccharides from Polygonatum cyrtonema Hua prevent post-traumatic stress disorder behaviors in mice: Mechanisms from the perspective of synaptic injury, oxidative stress, and neuroinflammation. [Abstract]

2024 Jan 30;319(Pt 1):117165. PMID: 37696440
J Ethnopharmacol

Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway. [Abstract]

2023 May 23:308:116253. PMID: 36806345
J Agric Food Chem

Nrf2/HO-1 Dysregulation is Involved in the Microplastic-Induced Gut-Liver Axis Damage Mechanism and the Protective Effect of Astaxanthin. [Abstract]

2026 Jul 1;74(25):19962-19978. PMID: 42308009
J Agric Food Chem

Galangin Mitigates Alcohol-Induced Intestinal Damage by Suppressing Ferroptosis via the SESN2/KEAP1/NRF2 Pathway in Mice and Caco-2 Cells. [Abstract]

2026 Feb 11;74(5):4781-4796. PMID: 41605867
J Agric Food Chem

Molecular Mechanism Study of Dietary Fiber Lignin Intervention in Ulcerative Colitis through GPR37. [Abstract]

2024 Jun 7. PMID: 38845410
J Agric Food Chem

Free and Bound Phenolics of Laird Lentil ( Lens culinaris) Hulls and the Anti-inflammatory Activity of their Digestive Products via Crosstalk between NF-κB and Keap1-Nrf2 Signaling Pathways in HT-29 Cells. [Abstract]

2022 Oct 19;70(41):13251-13263. PMID: 36196880
J Agric Food Chem

Apple Polyphenols Improve Intestinal Antioxidant Capacity and Barrier Function by Activating the Nrf2/Keap1 Signaling Pathway in a Pig Model. [Abstract]

2022 Jun 22;70(24):7576-7585. PMID: 35679090
J Agric Food Chem

Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway. [Abstract]

2022 Mar 9;70(9):2923-2935. PMID: 35195395
J Agric Food Chem

Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling. [Abstract]

2021 Sep 15;69(36):10606-10616. PMID: 34482683
J Agric Food Chem

Polysaccharide from Mulberry Fruit ( Morus alba L.) Protects against Palmitic-Acid-Induced Hepatocyte Lipotoxicity by Activating the Nrf2/ARE Signaling Pathway. [Abstract]

2020 Nov 18;68(46):13016-13024. PMID: 31537067
Ecotoxicol Environ Saf

Water-insoluble components of PM2.5 are major triggers of pulmonary ferroptosis by inducing mitochondrial damage via Nrf2/Prdx6 pathway. [Abstract]

2026 Aug:321:120359. PMID: 42296917
CNS Neurosci Ther

DL-3-n-Butylphthalide Protects Against PrP106 -126-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial Dynamics. [Abstract]

2026 Jun;32(6):e70948. PMID: 42228054
CNS Neurosci Ther

Mechanism of Hypoxia-Induced HMGB1 Regulating NLRP3 Inflammasome/Caspase-1 Pathway-Mediated Pyroptosis in Myocardial Ischemia Reperfusion Injury Through the Nrf2/HO-1 Pathway. [Abstract]

2025 Dec;31(12):e70661. PMID: 41378869
Ecotoxicol Environ Saf

Lycopene inhibits zearalenone-induced ferroptosis via activating AMPK/Nrf2 signaling pathway in AML-12 hepatocytes and in mice livers. [Abstract]

2025 Sep 15:303:119045. PMID: 40945091
Ecotoxicol Environ Saf

Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors. [Abstract]

2024 Nov 15:287:117266. PMID: 39509784
CNS Neurosci Ther

Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2/NF-κB/NLRP3 pathway. [Abstract]

2024 Mar;30(3):e14454. PMID: 37697971
CNS Neurosci Ther

Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway. [Abstract]

2023 Nov;29(11):3460-3478. PMID: 37269088
Ecotoxicol Environ Saf

Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice. [Abstract]

2023 Oct 15:265:115534. PMID: 37776821
Biochem Pharmacol

RNA-binding protein RBM47 enhances ENC1 stability through AU-rich elements to induce oxidative stress in macrophages in atherosclerosis progression. [Abstract]

2026 Aug;250(Pt 1):117953. PMID: 41962778
Biochem Pharmacol

Pharmacological activation of GPX4 by selenomethionine attenuates cisplatin-induced ototoxicity and hearing loss. [Abstract]

2026 Jun:248:117816. PMID: 41698483
Biochem Pharmacol

Artesunate reduces oxidative stress and inflammation in NAFLD by activating the Nrf2 pathway. [Abstract]

2026 Mar:245:117643. PMID: 41412549
Biochem Pharmacol

Diacerein protects against Ovariectomy-Induced bone loss via reversal of NRF2 epigenetic suppression. [Abstract]

2026 Jan 24:247:117748. PMID: 41587594
Cell Mol Life Sci

IL-38 attenuates vascular calcification by upregulating GPX3-mediated antioxidant defense via the PPAR-γ/NRF2 axis. [Abstract]

2025 Nov 27;83(1):19. PMID: 41307654
Biochem Pharmacol

WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2025 Mar:233:116790. PMID: 39894307
Cell Mol Life Sci

Glucose metabolite methylglyoxal induces vascular endothelial cell pyroptosis via NLRP3 inflammasome activation and oxidative stress in vitro and in vivo. [Abstract]

2024 Sep 13;81(1):401. PMID: 39269632
Biochem Pharmacol

Furanodienone induces apoptosis via regulating the PRDX1/MAPKs/p53/caspases signaling axis through NOX4-derived mitochondrial ROS in colorectal cancer cells. [Abstract]

2024 Sep:227:116456. PMID: 39079582
Int J Mol Sci

Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced Failure of Neural Tube Closure. [Abstract]

2024 May 21;25(11):5588. PMID: 38891776
Biochem Pharmacol

Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells. [Abstract]

2022 May;199:115017. PMID: 35346662
Mol Ther Nucleic Acids

TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway. [Abstract]

2022 Mar 28;28:435-449. PMID: 35505966
Biochem Pharmacol

Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. [Abstract]

2018 Sep:155:494-509. PMID: 30071202

ML385 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Sep:155:494-509. [Abstract]

THP-1 cells are incubated with Cardamonin (30 μM), ML385 (5 μM) and ML385 + Cardamonin for 21 h, stimulated with LPS (2 μg/mL) for 3 h, and followed by ATP (5 mM) treatment for 30 min. The protein levels of NLRP3, cleaved caspase-1, ASC and cleaved IL-1β are detected by western blotting assay.
Life Sci

Exogenous hydrogen sulphide alleviates diabetes-associated cognitive decline by inhibiting ferroptosis through Nrf2/GPX4 signalling pathway. [Abstract]

2026 Mar 1:388:124220. PMID: 41577177
Life Sci

A novel zinc ferrite nanoparticle protects against MSU-induced gout arthritis via Nrf2/NF-κB/NLRP3 pathway. [Abstract]

2025 Apr 1:366-367:123475. PMID: 39983819
Life Sci

Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway. [Abstract]

2025 Mar 15:365:123452. PMID: 39923835
Life Sci

Quercetin protects against iron overload-induced osteoporosis through activating the Nrf2/HO-1 pathway. [Abstract]

2023 Jun 1:322:121326. PMID: 36639053
Life Sci

Zinc promotes functional recovery after spinal cord injury by activating Nrf2/HO-1 defense pathway and inhibiting inflammation of NLRP3 in nerve cells. [Abstract]

2020 Mar 15;245:117351. PMID: 31981629
Food Front

2025 Nov 20.
Biomed J

Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway. [Abstract]

2025 Oct;48(5):100826. PMID: 39755172
Food Funct

Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota. [Abstract]

2023 Aug 14;14(16):7692-7704. PMID: 37545398
Food Funct

Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice. [Abstract]

2023 Jul 31;14(15):7176-7194. PMID: 37462424
Food Funct

Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway. [Abstract]

2021 Sep 20;12(18):8800-8811. PMID: 34374402
Inflammopharmacology

Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation. [Abstract]

2020 Dec;28(6):1495-1508. PMID: 32596762
Food Biosci

2026 May 8;80:109051.
Bioeng Transl Med

2025 Dec 29.
Inflamm Res

A novel anti-acute lung injury mechanism of astilbin: inhibition of epithelial cells ferroptosis by targeting NRF2 activation via binding Val608 site of NRF2. [Abstract]

2025 Oct 30;74(1):155. PMID: 41165829
Inflamm Res

Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2/HO-1/GPX4 signaling pathway in primary Sjögren's syndrome. [Abstract]

2025 May 24;74(1):84. PMID: 40413364
Inflamm Res

Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling. [Abstract]

2024 Dec;73(12):2069-2085. PMID: 39294398
Inflamm Res

Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury. [Abstract]

2024 Nov;73(11):1981-1994. PMID: 39340662
Liver Int

Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction. [Abstract]

2023 Apr;43(4):865-877. PMID: 36627827
Food Biosci

14 October 2021, 101408.
Drug Des Devel Ther

Bu Shen Huo Xue Formula Provides Neuroprotection Against Spinal Cord Injury by Inhibiting Oxidative Stress by Activating the Nrf2 Signaling Pathway. [Abstract]

2024 Oct 25:18:4779-4797. PMID: 39494153
Drug Des Devel Ther

Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO-1 Signaling Pathway. [Abstract]

2024 Apr 18:18:1265-1275. PMID: 38651136
Drug Des Devel Ther

Levistilide a Induces Ferroptosis by Activating the Nrf2/HO-1 Signaling Pathway in Breast Cancer Cells. [Abstract]

2022 Sep 7:16:2981-2993. PMID: 36105321
Drug Des Devel Ther

Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway. [Abstract]

2021 Nov 30;15:4837-4848. PMID: 34876806
Drug Des Devel Ther

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway. [Abstract]

2020 Nov 13:14:4901-4913. PMID: 33223823
Pharm Biol

Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts. [Abstract]

2026 Dec;64(1):764-782. PMID: 42165632
Pharm Biol

The role of salvianolic acid B and benzoylpaeoniflorin in enhancing angiogenesis through Nrf2/HO-1/VEGFA signaling axis in ischemic stroke recovery. [Abstract]

2026 Dec;64(1):67-86. PMID: 41433220
Cells

Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion. [Abstract]

2024 Nov 28;13(23):1969. PMID: 39682718
Cells

KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling. [Abstract]

2022 Oct 27;11(21):3393. PMID: 36359788
Cells

Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome. [Abstract]

2022 Sep 8;11(18):2809. PMID: 36139384
Pharm Biol

5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes. [Abstract]

2020 Dec;58(1):999-1005. PMID: 32981407
Nat Prod Bioprospect

Oligosaccharides from Polygonatum cyrtonema Hua ameliorate colitis-induced lung injury via modulation of the gut-lung axis through NF-κB and Nrf2 pathways. [Abstract]

2026 Jun 23;16(1):70. PMID: 42334735
Pharmaceuticals (Basel)

Liquiritigenin Ameliorates Rheumatoid Arthritis by Modulating the Nrf2/NF-κB/NLRP3 Pathway in Fibroblast-like Synoviocytes. [Abstract]

2026 May 17;19(5):785. PMID: 42198459
Eur J Pharmacol

Inhibition of ferroptosis exerts renal protective effects in membranous nephropathy rats via the Nrf2/HO-1 pathway. [Abstract]

2026 May 28:1025:178898. PMID: 42044765
Eur J Pharmacol

Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway. [Abstract]

2026 Mar 28:1019:178726. PMID: 41802484
Eur J Pharmacol

Alpha-lipoic acid alleviated intermittent hypoxia-induced myocardial injury in mice by promoting autophagy through Nrf2 signaling pathway. [Abstract]

2025 May 5:994:177380. PMID: 39954840
Mar Drugs

Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian Cancer. [Abstract]

2025 Mar 12;23(3):123. PMID: 40137309
Respir Res

REDD1 mediates HDM-induced nuclear-cytoplasmic translocation and release of IL-33 in airway epithelial cells by downregulating Nrf2. [Abstract]

2025 Feb 1;26(1):47. PMID: 39893427
Cell Biol Toxicol

Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin. [Abstract]

2024 Dec 20;41(1):2. PMID: 39707073
Reprod Biol Endocrinol

Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression. [Abstract]

2024 Apr 11;22(1):41. PMID: 38605340
Eur J Pharmacol

Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2/SLC7A11/GPX4 signalling pathway. [Abstract]

2024 Mar 15:967:176402. PMID: 38331339
Eur J Pharmacol

Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway. [Abstract]

2023 Oct 5:956:175985. PMID: 37572943
Eur J Pharmacol

Kinsenoside alleviates oxidative stress-induced blood-brain barrier dysfunction via promoting Nrf2/HO-1 pathway in ischemic stroke. [Abstract]

2023 Jun 15:949:175717. PMID: 37054938
Eur J Pharmacol

Astragaloside IV mitigates cerebral ischaemia-reperfusion injury via inhibition of P62/Keap1/Nrf2 pathway-mediated ferroptosis. [Abstract]

2023 Apr 5:944:175516. PMID: 36758783
Respir Res

Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis. [Abstract]

2020 Sep 9;21(1):232. PMID: 32907551
Int Immunopharmacol

Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis. [Abstract]

2026 Jul 1:180:116703. PMID: 42025422
Int Immunopharmacol

Daphnetin alleviates neuropathic pain in rats by modulating spinal microglial polarization via the Nrf2/NLRP3 inflammasome pathway. [Abstract]

2026 Jun 17:185:116986. PMID: 42308799
Int Immunopharmacol

Luteolin mitigates inflammatory organ injury by targeting XIAP to block PANoptosis and mitochondrial dysfunction. [Abstract]

2026 Mar 15:173:116271. PMID: 41637826
Int Immunopharmacol

GDF11 protects against sepsis-induced myocardial injury and cardiac dysfunction by targeting the Nrf2 signaling pathway-dependent ferroptosis. [Abstract]

2026 Mar 15:173:116318. PMID: 41637825
Cell Oncol (Dordr)

NUAK1 silencing enhances radiotherapy-induced ferroptosis in locally advanced rectal cancer by impairing Nrf2-driven transcription of GPX4. [Abstract]

2026 Mar 18;49(2):57. PMID: 41848996
Int J Mol Sci

Hydrogen Mitigated Doxorubicin-Induced Liver Injury via Nrf2/HO-1 Pathway Activation. [Abstract]

2026 Mar 19;27(6):2774. PMID: 41898634
Int Immunopharmacol

Paeoniflorin suppresses cardiomyocyte pyroptosis and ameliorates diabetic cardiomyopathy by AMPK/Nrf2/NLRP3 pathway. [Abstract]

2026 Feb 15:171:116122. PMID: 41477992
Int Immunopharmacol

Trimethyltin chloride (TMT) - induced vascular injury through ubiquitination proteasome pathway - regulated GPX4 degradation. [Abstract]

2026 Mar 15:173:116250. PMID: 41605050
Int Immunopharmacol

Hydrogen alleviates cardiac ferroptosis damage under chronic intermittent hypoxia conditions by targeting Nrf2. [Abstract]

2026 Jan 15:169:115974. PMID: 41370977
Int J Mol Sci

Aspirin Eugenol Ester Ameliorates Fatty Liver Hemorrhagic Syndrome in Laying Hens by Reducing Oxidative Stress and Inflammation. [Abstract]

2026 Jan;27(11):4811. PMID: 42278341
Int Immunopharmacol

Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function. [Abstract]

2026 Jan 1;168(Pt 2):115879. PMID: 41314045
Int Immunopharmacol

Ozone rectal insufflation attenuates lung inflammation by inhibiting the TLR4/NF-κB pathway through upregulation of Nrf2 in mice with COPD-like pathology. [Abstract]

2025 Dec 10:167:115676. PMID: 41115352
Int Immunopharmacol

Galanin regulates M1/M2 polarization of microglia after spinal cord injury through TRPV1/Ca2+/CaMKII/NRF2 signaling pathway. [Abstract]

2025 Oct 30:164:115330. PMID: 40811950
Int Immunopharmacol

Targeting GCS regulates the NRF2 axis to inhibit hepatocyte endoplasmic reticulum stress-ferroptosis improving immune-mediated liver injury. [Abstract]

2025 Sep 13:165:115532. PMID: 40946670
Int J Mol Sci

Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway. [Abstract]

2025 Jul 25;26(15):7204. PMID: 40806353
Int Immunopharmacol

Mesenchymal stromal cells reduce ferroptosis of podocytes by activating the Nrf2/HO-1/GPX4 pathway in lupus nephritis. [Abstract]

2025 Apr 24:153:114537. PMID: 40147265
Int Immunopharmacol

Sulforaphane promotes diabetic wound healing by regulating macrophage efferocytosis and polarization. [Abstract]

2025 Mar 26:150:114243. PMID: 39938166
Int J Mol Sci

HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-GSDMD Pathway in Recent-Onset Schizophrenia. [Abstract]

2025 Jan 9;26(2):520. PMID: 39859234
Int Immunopharmacol

Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis. [Abstract]

2024 Nov 15:141:113020. PMID: 39208524
Int Immunopharmacol

Quercetin Protects against Silicon dioxide Particles-induced spleen ZBP1-Mediated PANoptosis by regulating the Nrf2/Drp1/mtDNA axis. [Abstract]

2024 Nov 2;143(Pt 3):113546. PMID: 39488923
Int J Mol Sci

Malvidin-3-O-Glucoside Mitigates α-Syn and MPTP Co-Induced Oxidative Stress and Apoptosis in Human Microglial HMC3 Cells. [Abstract]

2024 Nov 27;25(23):12733. PMID: 39684444
Int Immunopharmacol

Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway. [Abstract]

2024 Oct 28;143(Pt 2):113478. PMID: 39471691
Int Immunopharmacol

Nrf2 inhibits M1 macrophage polarization to ameliorate renal ischemia-reperfusion injury through antagonizing NF-κB signaling. [Abstract]

2024 Oct 8;143(Pt 1):113310. PMID: 39383788
Int Immunopharmacol

Tricetin attenuates atherosclerosis by suppressing macrophage ferroptosis via activation of the NRF2 pathway. [Abstract]

2024 Oct 22;143(Pt 2):113418. PMID: 39442188
Int Immunopharmacol

Micheliolide ameliorates lipopolysaccharide-induced acute kidney injury through suppression of NLRP3 activation by promoting mitophagy via Nrf2/PINK1/Parkin axis. [Abstract]

2024 Sep 10:138:112527. PMID: 38950457
Int Immunopharmacol

GLP-1 analogue liraglutide attenuates CIH-induced cognitive deficits by inhibiting oxidative stress, neuroinflammation, and apoptosis via the Nrf2/HO-1 and MAPK/NF-κB signaling pathways. [Abstract]

2024 Sep 24;142(Pt B):113222. PMID: 39321702
Int Immunopharmacol

QBT improved cognitive dysfunction in rats with vascular dementia by regulating the Nrf2/xCT/GPX4 and NLRP3/Caspase-1/GSDMD pathways to inhibit ferroptosis and pyroptosis of neurons. [Abstract]

2024 Sep 11;142(Pt A):113070. PMID: 39265351
Int Immunopharmacol

Asiatic acid induces ferroptosis of RA-FLS via the Nrf2/HMOX1 pathway to relieve inflammation in rheumatoid arthritis. [Abstract]

2024 Aug 20:137:112394. PMID: 38852517
Int Immunopharmacol

Moringin alleviates DSS-induced ulcerative colitis in mice by regulating Nrf2/NF-κB pathway and PI3K/AKT/mTOR pathway. [Abstract]

2024 Jun 15:134:112241. PMID: 38761782
Int J Mol Sci

TRIM21 Promotes Oxidative Stress and Ferroptosis through the SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly Pathogenic Avian Influenza Virus. [Abstract]

2024 Mar 14;25(6):3315. PMID: 38542289
Int Immunopharmacol

Isobavachalcone attenuates liver fibrosis via activation of the Nrf2/HO-1 pathway in rats. [Abstract]

2024 Feb 15:128:111398. PMID: 38171054
Int Immunopharmacol

Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury. [Abstract]

2024 Jan 25:127:111432. PMID: 38142644
Int Immunopharmacol

Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress. [Abstract]

2024 Jan 25:127:111382. PMID: 38141412
Int J Mol Sci

Vitamin D Improves Cognitive Impairment and Alleviates Ferroptosis via the Nrf2 Signaling Pathway in Aging Mice. [Abstract]

2023 Oct 18;24(20):15315. PMID: 37894993
Int Immunopharmacol

BNTA attenuates temporomandibular joint osteoarthritis progression by directly targeting ALDH3A1: An in vivo and in vitro study. [Abstract]

2023 Sep 21;124(Pt B):110963. PMID: 37741125
Int Immunopharmacol

Roflumilast attenuates neuroinflammation post retinal ischemia/reperfusion injury by regulating microglia phenotype via the Nrf2/STING/NF-κB pathway. [Abstract]

2023 Sep 24;124(Pt B):110952. PMID: 37751655
Int J Mol Sci

FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway. [Abstract]

2023 Sep 18;24(18):14215. PMID: 37762517
Int Immunopharmacol

Aloperine alleviates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome activation. [Abstract]

2023 Jul:120:110142. PMID: 37210910
Int J Mol Sci

Propolis Ethanolic Extract Attenuates D-gal-induced C2C12 Cell Injury by Modulating Nrf2/HO-1 and p38/p53 Signaling Pathways. [Abstract]

2023 Mar 29;24(7):6408. PMID: 37047379
Int Immunopharmacol

Maresin1 ameliorates ventricular remodelling and arrhythmia in mice models of myocardial infarction via NRF2/HO-1 and TLR4/NF-kB signalling. [Abstract]

2022 Dec;113(Pt A):109369. PMID: 36279667
Int Immunopharmacol

Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury. [Abstract]

2022 Nov:112:109162. PMID: 36067654
Int Immunopharmacol

Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway. [Abstract]

2022 Jul:108:108864. PMID: 35623293
Biomolecules

Excess Heme Promotes the Migration and Infiltration of Macrophages in Endometrial Hyperplasia Complicated with Abnormal Uterine Bleeding. [Abstract]

2022 Jun 19;12(6):849. PMID: 35740976
Int Immunopharmacol

Ginsenoside Rd attenuates cerebral ischemia/reperfusion injury by exerting an anti-pyroptotic effect via the miR-139-5p/FoxO1/Keap1/Nrf2 axis. [Abstract]

2022 Apr:105:108582. PMID: 35124564
Biomolecules

Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis. [Abstract]

2021 Jun 22;11(7):923. PMID: 34206421
Int Immunopharmacol

Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway. [Abstract]

2021 Apr:93:107426. PMID: 33550032
Int Immunopharmacol

Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in an Nrf2-dependent pathway. [Abstract]

2020 Aug:85:106585. PMID: 32447221
Mol Neurobiol

Inhibition of DRP1-mediated Mitochondrial Fission and NRF2/HO-1/GPX4-mediated Ferroptosis by Mdivi-1 Protects Against Vascular Cognitive Impairment. [Abstract]

2025 Nov 19;63(1):76. PMID: 41254362
Mol Neurobiol

Chrysin Improves Cognitive Dysfunction in Rats with Intracerebral Hemorrhage by Regulating the Nrf2/GPX4 Pathway to Inhibit Ferroptosis. [Abstract]

2025 Nov 13;63(1):35. PMID: 41231360
Neurochem Int

Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling. [Abstract]

2025 Sep:188:105997. PMID: 40436344
Mol Neurobiol

Activation of the Nrf2 Signaling Pathway by Tetrahydroberberine Suppresses Ferroptosis and Enhances Functional Recovery Following Spinal Cord Injury. [Abstract]

2025 Jul;62(7):8439-8456. PMID: 40011360
Mol Neurobiol

ROS Regulate Rotenone-induced SH-SY5Y Dopamine Neuron Death Through Ferroptosis-mediated Autophagy and Apoptosis. [Abstract]

2025 Jul;62(7):9271-9289. PMID: 40097764
Bone Joint Res

Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors. [Abstract]

2023 Mar 7;12(3):202-211. PMID: 37051810
Neurochem Int

Dimethyl itaconate inhibits neuroinflammation to alleviate chronic pain in mice. [Abstract]

2022 Mar:154:105296. PMID: 35121012
Inflammation

Evidence that a Novel Chalcone Derivative, Compound 27, Acts on the Epithelium Via the PI3K/AKT/Nrf2-Keap1 Signaling Pathway, to Mitigate LPS-Induced Acute Lung Injury in Mice. [Abstract]

2025 Apr;48(2):590-606. PMID: 38789816
Inflammation

Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway. [Abstract]

2024 Oct;47(5):1793-1805. PMID: 38598115
Front Pharmacol

Integrating network pharmacology, molecular docking and experimental verification to reveal the mechanism of artesunate in inhibiting choroidal melanoma. [Abstract]

2024 Aug 9:15:1448381. PMID: 39185308
Front Pharmacol

Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway. [Abstract]

2022 Aug 31;13:958916. PMID: 36120334
Front Pharmacol

Melatonin Improved the Survival of Multi-Territory Perforator Flaps by Promoting Angiogenesis and Inhibiting Apoptosis via the NRF2/FUNDC1 Axis. [Abstract]

2022 May 24:13:921189. PMID: 35685624
Front Pharmacol

Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling. [Abstract]

2021 May 18;12:644116. PMID: 34084132
Front Pharmacol

4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response. [Abstract]

2021 May 25:12:651444. PMID: 34113251
Front Pharmacol

Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. [Abstract]

2020 Jul 31:11:1038. PMID: 32903813
Front Pharmacol

Neuroprotective Effects of a Traditional Multi-Herbal Medicine Kyung-Ok-Ko in an Animal Model of Parkinson's Disease: Inhibition of MAPKs and NF-κB Pathways and Activation of Keap1-Nrf2 Pathway. [Abstract]

2018 Dec 13:9:1444. PMID: 30618742

ML385 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Dec 13:9:1444. [Abstract]

Seven days after the last MPTP intoxication, nucleus, and cytosol isolated from SNpc and striatum from all groups (sham, KOK, KOK+ML385, ML385, KOK, ML385) are subjected to Western blot assay to quantify changes in Nrf2 nuclear translocation and NQO1 expression, respectively.

ML385 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Dec 13:9:1444. [Abstract]

Seven days after the last MPTP intoxication, SNpc and striatal sections (n = 3 per brain) are subjected to immunofluorescence staining using Nrf2 and NQO1 antibodies with the treatments (sham, KOK, KOK+ML385, ML385, KOK, ML385).
J Ovarian Res

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles harboring IGF-1 improve ovarian function of mice with premature ovarian insufficiency through the Nrf2/HO-1 pathway. [Abstract]

2024 Nov 14;17(1):224. PMID: 39543679
Front Chem

Porous COS@SiO2 Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice. [Abstract]

2020 Oct 7;8:720. PMID: 33134248
Front Cell Dev Biol

Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation. [Abstract]

2020 Jul 17;8:559. PMID: 32766240
J Nutr Biochem

Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2. [Abstract]

2026 Sep:155:110381. PMID: 41997457
J Nutr Biochem

Caffeic acid improves intestinal barrier function integrity through activation of Nrf2 signaling pathway in weaned piglets and H2O2 induced IPEC-J2 cells. [Abstract]

2025 Sep:143:109952. PMID: 40339722
ACS Omega

Dopamine Alleviated Diabetic Retinal Neurodegeneration through Protecting Retinal Ganglion Cells from Ferroptosis via the Nrf2/HO‑1 Signaling Pathway. [Abstract]

2025 Jul 14;10(28):30397-30410. PMID: 40727724
Chem Biol Interact

The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway. [Abstract]

2025 May 1:412:111459. PMID: 40054827
Chem Biol Interact

Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF-κB and MAPK pathways in an Nrf2-dependent manner. [Abstract]

2024 Jun 1:396:111030. PMID: 38692452
Chem Biol Interact

Malvidin promotes PGC-1α/Nrf2 signaling to attenuate the inflammatory response and restore mitochondrial activity in septic acute kidney injury. [Abstract]

2024 Jan 25:388:110850. PMID: 38135199
Toxicology

Sappanone A ameliorates acetaminophen-induced acute liver injury in mice. [Abstract]

2022 Oct:480:153336. PMID: 36126895
Bioorg Chem

The RIP3 activator C8 regulates the autophagy flux mediated by p62 and promotes the immunogenic form of cell death in human gastric cancer cells. [Abstract]

2024 Dec:153:107937. PMID: 39520785
Eur J Pharm Sci

Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis. [Abstract]

2024 Dec 1:203:106923. PMID: 39368783
Molecules

Procyanidins Alleviated Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the Nrf2/HO-1 Signaling Pathway. [Abstract]

2023 Apr 20;28(8):3582. PMID: 37110816
Molecules

Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. [Abstract]

2022 Sep 24;27(19):6311. PMID: 36234847
Eur J Pharm Sci

Advanced oxidation protein products upregulate efflux transporter expression and activity through activation of the Nrf-2-mediated signaling pathway in vitro and in vivo. [Abstract]

2020 Jun 15:149:105342. PMID: 32315774
Exp Gerontol

Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway. [Abstract]

2017 Dec 15:100:77-86. PMID: 29079145

ML385 purchased from MedChemExpress. Usage Cited in: Exp Gerontol. 2017 Dec 15:100:77-86. [Abstract]

Cells are treated with ML385 at the concentration of 5 μM for 12 h. The expression of Nrf2 and its translocation into nucleus are determined using western blot analysis.
Mol Med Rep

Protective effects of lipid mediators, obtained from docosahexaenoic acid via soybean lipoxygenase, on lipopolysaccharide‑induced acute lung injury through the NF‑κB and Nrf2/HO‑1 signaling pathways. [Abstract]

2025 Sep;32(3):233. PMID: 40539450
J Mol Med (Berl)

Flotillin- 1 ameliorates experimental diabetic retinopathy by inhibiting ferroptosis in blood-retinal barrier. [Abstract]

2025 Apr 8. PMID: 40198383
Biochim Biophys Acta Mol Basis Dis

Nrf2 protects against oxidative damage induced by hemoglobin in the liver of grass carp (Ctenopharyngodon idella). [Abstract]

2024 Nov 29;1871(3):167600. PMID: 39615659
Mol Med Rep

gCTRP3 inhibits oophorectomy‑induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice. [Abstract]

2024 Aug;30(2):133. PMID: 38818814
Biochim Biophys Acta Mol Basis Dis

Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway. [Abstract]

2024 Feb;1870(2):166977. PMID: 38065271
Mol Med Rep

Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway. [Abstract]

2023 Jan;27(1):2. PMID: 36321783
Mol Med Rep

Coptisine attenuates post‑infectious IBS via Nrf2‑dependent inhibition of the NLPR3 inflammasome. [Abstract]

2022 Dec;26(6):362. PMID: 36281933
Mol Med Rep

NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria. [Abstract]

2022 Mar;25(3):84. PMID: 35029280
Mol Med Rep

Inflammatory response and oxidative stress attenuated by sulfiredoxin‑1 in neuron‑like cells depends on nuclear factor erythroid‑2‑related factor 2. [Abstract]

2020 Dec;22(6):4734-4742. PMID: 33173963
Biochim Biophys Acta Mol Basis Dis

Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway. [Abstract]

2018 Mar;1864(3):882-890. PMID: 29287777

ML385 purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):882-890. [Abstract]

RAW264.7 cells are transfected with ML385 (5 μM) in the presence of Tan C (10 μM) for 24 h. Prdx1 and Nrf2 protein expression is determined by Western blotting
Mol Pharm

g-C3N4 Nanosheets as a Ferroptosis-Targeted Nanoprobe: Mitigating Iron Overload and Restoring Male Fertility via Nrf2 Pathway Activation. [Abstract]

2026 May 4;23(5):2857-2870. PMID: 41964938
Mol Pharm

Curcumin-Loaded Liposomes (hPLipo/Cur) with Liver-Targeting Properties for Efficient NAFLD Treatment by Alleviating Mitochondrial ROS-Mediated Ferroptosis via NRF2 Pathway. [Abstract]

2026 Apr 6;23(4):2398-2411. PMID: 41725216
Sci Rep

Gnetum montanum extract attenuates lipopolysaccharide induced acute lung inflammation through Nrf2 and heme oxygenase 1 mediated redox modulation in macrophages. [Abstract]

2026 Apr 24;16(1):18995. PMID: 42031984
APL Bioeng

Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis. [Abstract]

2026 Jan 30;10(1):016107. PMID: 41624806
Sci Rep

IL-22 attenuates MAFLD progression by modulating oxidative stress and ferroptosis. [Abstract]

2025 Nov 23. PMID: 41276549
APL Bioeng

Low-intensity pulsed ultrasound alleviates periodontitis in mice with T2DM through Nrf2 pathway. [Abstract]

2025 Oct 16;9(4):046105. PMID: 41113107
Transplantation

Does NRF2 Play a Double-edged Role in Acute GVHD Pathogenesis?. [Abstract]

2025 Aug 22. PMID: 40841863
Transplantation

The Aberrantly Expressed Nuclear Factor (Erythroid-derived 2)-Like 2 Participates in aGVHD by Modulating the Activation and Differentiation of CD4+ T Lymphocytes. [Abstract]

2025 Jul 1;109(7):1152-1165. PMID: 39915920
Sci Rep

Ginsenoside Rg1 regulating inflammatory response and bone-remodeling through Keap1/Nrf2 signaling pathway in rats with periodontitis. [Abstract]

2025 Mar 3;15(1):7478. PMID: 40033022
Sci Rep

6-hydroxygenistein attenuates hypoxia-induced injury via activating Nrf2/HO-1 signaling pathway in PC12 cells. [Abstract]

2025 Jan 6;15(1):875. PMID: 39762378
Transl Oncol

Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis. [Abstract]

2024 Oct:48:102077. PMID: 39106550
Sci Rep

Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage. [Abstract]

2024 May 30;14(1):12427. PMID: 38816543
Sci Rep

Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis. [Abstract]

2024 Feb 9;14(1):3335. PMID: 38336964
Diabetol Metab Syndr

Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis. [Abstract]

2023 Nov 22;15(1):239. PMID: 37993958
Sci Rep

Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis. [Abstract]

2023 Sep 1;13(1):14359. PMID: 37658132
Mediators Inflamm

Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis. [Abstract]

2022 Mar 11:2022:5766434. PMID: 35310452
Sci Rep

Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses. [Abstract]

2020 Apr 14;10(1):6427. PMID: 32286474
Exp Neurol

Salvianolic acid B exerts cerebroprotective effects after traumatic brain injury via Nrf2-dependent antioxidant and anti-inflammatory cascades. [Abstract]

2025 Sep:391:115305. PMID: 40383364
Exp Neurol

Effect of esketamine pretreatment on acute sepsis-associated encephalopathy. [Abstract]

2024 Feb:372:114646. PMID: 38070725
Exp Neurol

OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury. [Abstract]

2022 Nov:357:114180. PMID: 35901974
Neoplasia

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Dec;23(12):1227-1239. PMID: 34768109
Mol Cell Biochem

Stress-specific expression of HSPA and DNAJ chaperones regulated by NRF2/HSF1 in neurodegenerative conditions. [Abstract]

2026 Jan 29. PMID: 41609899
J Cell Mol Med

Exploring the Effect and Mechanism of Liraglutide in Treating Depression Based on Network Pharmacology and Experimental Analysis. [Abstract]

2025 Jun;29(11):e70630. PMID: 40461955
Neuropharmacology

Swietenolide inhibits the TXNIP/NLRP3 pathways via Nrf2 activation to ameliorate cognitive dysfunction in diabetic mice. [Abstract]

2025 Apr 1:267:110312. PMID: 39824302
Cell Signal

METTL14-mediated depression of NEIL1 aggravates oxidative damage and mitochondrial dysfunction of lens epithelial cells through regulating KEAP1/NRF2 pathways. [Abstract]

2025 Mar:127:111623. PMID: 39855533
Med Oncol

ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma. [Abstract]

2024 Nov 7;41(12):309. PMID: 39511054
J Cell Mol Med

Plumbagin ameliorates LPS-induced acute lung injury by regulating PI3K/AKT/mTOR and Keap1-Nrf2/HO-1 signalling pathways. [Abstract]

2024 Jul;28(13):e18386. PMID: 38990057
J Cell Mol Med

Apocynin exerts cytoprotective effects on dexamethasone-induced osteoblasts by inhibiting oxidative stress through the Nrf2 signalling pathway. [Abstract]

2023 Dec;27(23):3911-3927. PMID: 37749949
Mol Cell Biochem

Bone marrow-derived mesenchymal stem cells ameliorate severe acute pancreatitis by inhibiting oxidative stress in rats. [Abstract]

2022 Dec;477(12):2761-2771. PMID: 35622186
J Inflamm Res

Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury. [Abstract]

2026 Jun 19:19:596461. PMID: 42345001
J Inflamm Res

ALDH2 Ameliorates Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and Pyroptosis by Nrf2/ROS Pathway. [Abstract]

2025 Aug 14:18:11095-11108. PMID: 40831518
J Inflamm Res

Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense. [Abstract]

2025 Jul 29:18:10061-10079. PMID: 40761383
J Inflamm Res

Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury. [Abstract]

2024 Dec 13:17:11041-11053. PMID: 39691306
J Inflamm Res

5-Methoxytryptophan Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating Nrf2-Mediated Mitophagy. [Abstract]

2024 Nov 27:17:9857-9873. PMID: 39618934
J Inflamm Res

Nrf2 Deficiency Exacerbates Parkinson's Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells. [Abstract]

2024 Sep 10:17:6277-6295. PMID: 39281779
J Inflamm Res

Electroacupuncture Pretreatment at Zusanli (ST36) Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice by Reducing Oxidative Stress via Activating Vagus Nerve-Dependent Nrf2 Pathway. [Abstract]

2023 Apr 17:16:1595-1610. PMID: 37092126
J Inflamm Res

Gut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid. [Abstract]

2022 Mar 30;15:2103-2119. PMID: 35386224
Biomedicines

Polydatin Attenuates Sepsis-Induced Lung Injury by Inhibiting Neutrophil Extracellular Traps Formation via Nrf2/HO-1 Pathway. [Abstract]

2026 Apr 5;14(4):827. PMID: 42072367
Poult Sci

NRF2 deficiency impairs proliferation and survival of chicken primordial germ cells via oxidative stress, mitochondrial dysfunction and apoptosis. [Abstract]

2026 Mar 12;105(6):106765. PMID: 41850075
Brain Res Bull

Treadmill exercise attenuates CUMS-induced depressive behaviors by modulating the UPRmt via the Nrf2/Keap1 pathway. [Abstract]

2026 Feb:235:111738. PMID: 41554300
Neurochem Res

Schisanhenol Inhibits MPTP/MPP+-Induced Ferroptosis in Dopaminergic Neurons Via Nrf2/TrxR1/GPX4 Pathway against Parkinson's Disease. [Abstract]

2025 Dec 29;51(1):26. PMID: 41460594
Brain Res Bull

Dexmedetomidine attenuates postoperative delirium by activating Nrf2 to reduce oxidative stress and blood-brain barrier disruption. [Abstract]

2025 Aug 24:230:111523. PMID: 40858194
ACS Infect Dis

Ebola Virus Glycoprotein Impairs Human Retinal Pigment Epithelial Barrier Function via the PI3K/Akt-Nrf2 Pathway. [Abstract]

2025 Apr 16. PMID: 40237321
Neurochem Res

Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway. [Abstract]

2025 Apr 9;50(2):138. PMID: 40202562
Poult Sci

L-Theanine attenuates oxidative damage induced by heat stress through the PI3K/AKT/Nrf2 signaling pathway in skeletal muscle cells. [Abstract]

2025 Apr 4;104(6):105140. PMID: 40203618
Neurochem Res

Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis. [Abstract]

2024 Aug;49(8):2131-2147. PMID: 38822984
Mol Nutr Food Res

Luteolin Attenuates Oxidative Stress and Colonic Hypermobility in Water Avoidance Stress Rats by Activating the Nrf2 Signaling Pathway. [Abstract]

2024 Jan;68(1):e2300126. PMID: 38037466
Mol Nutr Food Res

Agaricus blazei Murrill Polysaccharide Attenuates Periodontitis via H2 S/NRF2 Axis-Boosted Appropriate Level of Autophagy in PDLCs. [Abstract]

2023 Nov;67(22):e2300112. PMID: 37775336
Neurochem Res

TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI. [Abstract]

2023 Sep;48(9):2808-2825. PMID: 37140776
Neurochem Res

Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury. [Abstract]

2023 Mar;48(3):956-966. PMID: 36402927
Brain Res Bull

Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway. [Abstract]

2022 Jun 1:183:38-48. PMID: 35227767
Brain Res Bull

Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway. [Abstract]

2020 Oct:163:40-48. PMID: 32679060
FASEB J

Nuclear Factor Erythroid 2-Related Factor 2-Dependent Ferroptosis Suppression by Salvianolic Acid B Preserves Microvascular Integrity and Reduces Risk Factors for Hemorrhagic Transformation After Cerebral Infarction. [Abstract]

2026 May 31;40(10):e71826. PMID: 42186809
FASEB J

Senkyunolide I Alleviated Renal Fibrosis in UUO Mice by Regulating the Nrf2/xCT/GPX4 and NLRP3/Caspase-1/GSDMD Pathways to Inhibit Ferroptosis and Pyroptosis. [Abstract]

2025 Nov 15;39(21):e71193. PMID: 41148161
FASEB J

Canagliflozin Delays Aortic Valve Calcification by Enhancing the AMPK/Nrf2/HO-1 Antioxidant Signaling Pathway in Valvular Interstitial Cells. [Abstract]

2025 May 31;39(10):e70630. PMID: 40357866
FASEB J

Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway. [Abstract]

2025 Jan 15;39(1):e70298. PMID: 39760183
FASEB J

Estrogen deficiency accelerates postmenopausal atherosclerosis by inducing endothelial cell ferroptosis through inhibiting NRF2/GPX4 pathway. [Abstract]

2023 Jun;37(6):e22992. PMID: 37219513
Antiviral Res

Identification of desoxyrhapontigenin as a novel antiviral agent against congenital Zika virus infection. [Abstract]

2023 Mar:211:105542. PMID: 36646387
FASEB J

Entacapone alleviates acute kidney injury by inhibiting ferroptosis. [Abstract]

2022 Jul;36(7):e22399. PMID: 35691001
Drug Dev Res

Polydatin Protects Against the Formation of PPE-Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear Factor Erythroid 2-Related Factor 2. [Abstract]

2026 Feb;87(1):e70223. PMID: 41486502
Int J Chron Obstruct Pulmon Dis

Bu-Fei Yi-Shen Formula Alleviates Oxidative Stress and Improves Airway Epithelial Barrier Dysfunction in COPD. [Abstract]

2026 May 13:21:580341. PMID: 42153136
J Virol

Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [Abstract]

2026 Feb 17;100(2):e0165625. PMID: 41489372
Curr Issues Mol Biol

Protective Effect of Hepcidin on Sepsis-Associated Acute Kidney Injury via Activating the Nrf2/GPX4 Signaling Pathway. [Abstract]

2025 Sep 18;47(9):772. PMID: 41020894
Microbiol Spectr

Capsiate attenuates atherosclerosis by activating Nrf2/GPX4 pathway and reshaping the intestinal microbiota in ApoE-/- mice. [Abstract]

2025 Apr;13(4):e0315524. PMID: 40029381
Front Biosci (Landmark Ed)

Protective Effects of Querectin against MPP+-Induced Dopaminergic Neurons Injury via the Nrf2 Signaling Pathway. [Abstract]

2023 Mar 2;28(3):42. PMID: 37005755
J Biol Chem

Antidiabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1. [Abstract]

2022 Dec;298(12):102678. PMID: 36356901
Cell Stress Chaperones

Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. [Abstract]

2022 Sep;27(5):461-478. PMID: 35689138
Cell Stress Chaperones

β-Glucan from Saccharomyces cerevisiae alleviates oxidative stress in LPS-stimulated RAW264.7 cells via Dectin-1/Nrf2/HO-1 signaling pathway. [Abstract]

2021 Jul;26(4):629-637. PMID: 33880723
Cell Stress Chaperones

Hydrolyzed camel whey protein alleviated heat stress-induced hepatocyte damage by activated Nrf2/HO-1 signaling pathway and inhibited NF-κB/NLRP3 axis. [Abstract]

2021 Mar;26(2):387-401. PMID: 33405053
J Cell Commun Signal

Trans-Coumaryl acetate mediates GRK5/NF-κB/Nrf2 signaling axis to ameliorate septic acute kidney injury. [Abstract]

2025 Sep 4;19(3):e70044. PMID: 40917114
Naunyn Schmiedebergs Arch Pharmacol

ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen. [Abstract]

2025 May 28. PMID: 40425765
Naunyn Schmiedebergs Arch Pharmacol

Liensinine attenuates inflammatory response and oxidative stress by activation of Nrf2/HO- 1 signaling in L-NAME-induced gestational hypertension. [Abstract]

2025 Apr 23. PMID: 40266297
Funct Integr Genomics

ALDH2 alleviates inflammation and facilitates osteogenic differentiation of periodontal ligament stem cells in periodontitis by blocking ferroptosis via activating Nrf2. [Abstract]

2024 Oct 7;24(5):184. PMID: 39370484
Toxins

Role of Nrf2 Nucleus Translocation in Beauvericin-Induced Cell Damage in Rat Hepatocytes. [Abstract]

2022 May 25;14(6):367. PMID: 35737028
Toxins

DL-Selenomethionine Alleviates Oxidative Stress Induced by Zearalenone via Nrf2/Keap1 Signaling Pathway in IPEC-J2 Cells. [Abstract]

2021 Aug 10;13(8):557. PMID: 34437428
J Immunol

Neddylation Alleviates Methicillin-Resistant Staphylococcus aureus Infection by Inducing Macrophage Reactive Oxygen Species Production. [Abstract]

2021 Jul 1;207(1):296-307. PMID: 34183370
Cell Cycle

CEBPB activates NRF2 to regulate the MAPK pathway through DUSP1 to promote proliferation and antioxidant capacity in ovarian cancer cells. [Abstract]

2025 Mar-Apr;24(5-8):122-140. PMID: 40726047
J Funct Foods

2025 May.
Bone

NRF2-mediated osteoblast anti-ferroptosis effect promotes induced membrane osteogenesis. [Abstract]

2025 Mar:192:117384. PMID: 39732449
J Funct Foods

2024 Oct.
J Funct Foods

2023 Sep, 108, 105756.
J Funct Foods

65 (2020) 103712.
J Funct Foods

2018 Jun; 45:313-320.
Ren Fail

ADAMTS13 ameliorates diabetic nephropathy by Nrf2/GPX4/eNOS signaling pathway. [Abstract]

2026 Dec;48(1):2646089. PMID: 41912450
Ren Fail

Resveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis. [Abstract]

2026 Dec;48(1):2652103. PMID: 41958068
Ren Fail

Curcumin regulates ferroptosis by activating α7 nicotinic acetylcholine receptor to improve sepsis-induced acute kidney injury. [Abstract]

2026 Dec;48(1):2657652. PMID: 42015821
Neurotoxicology

Astragaloside IV attenuates cisplatin-induced ototoxicity by preserving mitochondrial function and activating the Nrf2 signaling pathway. [Abstract]

2026 May:114:103451. PMID: 41990879
Metab Brain Dis

Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway. [Abstract]

2025 Nov 5;40(8):306. PMID: 41191138
Vet Res

Proanthocyanidins carbon dots inhibit PRRSV infection by activating Nrf2/ARE to regulate oxidative stress and NLRP3 inflammasome-mediated pyroptosis. [Abstract]

2025 Oct 16;56(1):197. PMID: 41102757
BMC Oral Health

Carnosic acid alleviated periodontitis by inhibiting ferroptosis via the Nrf2/GPX4 pathway. [Abstract]

2025 Oct 21;25(1):1648. PMID: 41121022
BMC Oral Health

BML-111 inhibit H2O2-induced pyroptosis and osteogenic dysfunction of human periodontal ligament fibroblasts by activating the Nrf2/HO-1 pathway. [Abstract]

2024 Jan 8;24(1):40. PMID: 38191432
Mol Immunol

NSUN2-mediated m⁵C methylation of HSPB1 mRNA suppresses inflammation and ferroptosis in ischemic stroke via activating the NRF2/HO-1/NQO-1 pathway. [Abstract]

2025 Dec:188:131-141. PMID: 41274106
J Pharm Pharmacol

Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1. [Abstract]

2025 Oct 17:rgaf075. PMID: 41105727
J Pharm Pharmacol

Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling. [Abstract]

2023 Nov 23;75(11):1467-1477. PMID: 37738327
J Pharm Pharmacol

Jie Geng Tang reverses cisplatin resistance through the Nrf2 pathway in lung cancer. [Abstract]

2023 Jun 5;75(6):784-805. PMID: 36971498
Mol Immunol

Dehydroepiandrosterone protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in hepatocytes. [Abstract]

2023 Mar:155:110-123. PMID: 36773597
Mol Immunol

Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages. [Abstract]

2021 Mar:131:97-111. PMID: 33461765
Cytokine

IL-35 alleviates ferroptosis in macrophage by activating the NRF2/GPX4 pathway to improve sepsis-induced ARDS. [Abstract]

2026 Feb:198:157086. PMID: 41370997
Toxicol Appl Pharmacol

Lutein inhibits ferroptosis and reduces neuronal cell death induced by Parkinson's disease through the NRF2-HMOX2 signaling axis. [Abstract]

2025 Dec:505:117570. PMID: 40972826
J Biochem Mol Toxicol

Quercetin Attenuates Cadmium-Induced Acute Lung Injury via Nrf2-Keap1 Pathway Activation. [Abstract]

2025 Sep;39(9):e70463. PMID: 40874705
J Biochem Mol Toxicol

Dihydroquercetin Ameliorates Neuronal Ferroptosis in Rats After Subarachnoid Hemorrhage via the PI3K/AKT/Nrf2/HO-1 Pathway. [Abstract]

2025 Jan;39(1):e70099. PMID: 39756058
Stem Cells Int

Exosomal miR-141-3p from PDLSCs Alleviates High Glucose-Induced Senescence of PDLSCs by Activating the KEAP1-NRF2 Signaling Pathway. [Abstract]

2023 May 26:2023:7136819. PMID: 37274022
Nanotoxicology

Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death. [Abstract]

2021 Aug;15(6):779-797. PMID: 33971103
Arch Med Res

Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress. [Abstract]

2021 Feb;52(2):163-173. PMID: 33645502
Toxicol Appl Pharmacol

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways. [Abstract]

2020 Jun 15:397:115014. PMID: 32320792
J Radiat Res Appl Sci

2026 Jun 11;19(3):102500.
Arch Biochem Biophys

Myricetin attenuates lipopolysaccharide-induced acute lung injury by suppressing pyroptosis via activation of the Nrf2/HO-1/NQO1 signaling pathway. [Abstract]

2026 May 16:110848. PMID: 42144067
Cardiovasc Drugs Ther

NR1D2 Knockdown Alleviates Myocardial Infarction through Nrf2 Signaling Pathway Activation. [Abstract]

2026 May 4. PMID: 42081055
J Radiat Res Appl Sci

2026 Mar 9.
Immun Inflamm Dis

Kaempferol Attenuates Oxidative Stress-Induced Injury in Gastric Mucosal Cells by Activating Nrf2/GPX4 Axis to Inhibit Ferroptosis. [Abstract]

2026 Feb;14(2):e70352. PMID: 41684188
J Diabetes Res

Targeting Oxidative Stress and Apoptosis via PI3K/Akt/Nrf2 Pathway: The Therapeutic Role of Bletilla striata Polysaccharide in Diabetic Wound Repair. [Abstract]

2026 Jan 28:2026:5751331. PMID: 41613340
Int J Biochem Cell Biol

Chromobox protein homolog 7 (CBX7) deficiency inhibits osteoblast ferroptosis by activating the Nrf2 function in type 2 diabetic osteoporosis. [Abstract]

2025 Dec:189:106866. PMID: 40998236
Arch Biochem Biophys

Astaxanthin-loaded polylactic acid-glycolic acid nanoparticles alleviates atherosclerosis by suppressing macrophage ferroptosis via the NRF2/SLC7A11/GPX4 pathway. [Abstract]

2025 Mar:765:110316. PMID: 39848420
Peptides

Cholecystokinin regulates atrial natriuretic peptide secretion through activation of NOX4-Sirt1-LEF1 signaling in beating rat hypoxic atria. [Abstract]

2024 Nov:181:171299. PMID: 39326462
J Reprod Immunol

Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta. [Abstract]

2023 Dec:160:104153. PMID: 37837670
Arch Biochem Biophys

Metformin ameliorates calcium oxalate crystallization and stone formation by activating the Nrf2/HO-1 signaling pathway: Two birds with one stone. [Abstract]

2023 May 1:739:109568. PMID: 36914110
Cell Biol Int

Protective effect of rutin on ferroptosis-induced oxidative stress in aging laying hens through Nrf2/HO-1 signaling. [Abstract]

2023 Mar;47(3):598-611. PMID: 36378583
Immun Inflamm Dis

Limonin ameliorates indomethacin-induced intestinal damage and ulcers through Nrf2/ARE pathway. [Abstract]

2023 Feb;11(2):e787. PMID: 36840501
Arch Biochem Biophys

Exosomes from M2-polarized macrophages relieve oxygen/glucose deprivation/normalization-induced neuronal injury by activating the Nrf2/HO-1 signaling. [Abstract]

2022 May 30;721:109193. PMID: 35321825
Hum Exp Toxicol

Neuroprotective potential of nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element signaling modulator cucurbitacin I upon glucose and oxygen deprivation/reperfusion (OGD/RP). [Abstract]

2022 Jan-Dec:41:9603271221104450. PMID: 35632987
Hum Exp Toxicol

Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway. [Abstract]

Jan-Dec 2022;41:9603271221087146. PMID: 35331031
Peptides

Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria. [Abstract]

2019 Dec:122:170150. PMID: 31541683
Brain Sci

Intranasal Administration of Apelin-13 Ameliorates Cognitive Deficit in Streptozotocin-Induced Alzheimer's Disease Model via Enhancement of Nrf2-HO1 Pathways. [Abstract]

2024 May 11;14(5):488. PMID: 38790466
Front Oncol

Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS-NF-кB-NLRP3 Axis. [Abstract]

2021 Sep 24:11:728047. PMID: 34631556
Front Oncol

LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells. [Abstract]

2021 Apr 16:11:658608. PMID: 33937072
Front Oncol

SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway. [Abstract]

2019 Aug 13:9:754. PMID: 31456942
Neuroscience

The protective effect of biochanin A on LPS/TNF-α-induced PD models is exerted by regulating ferroptosis through the Sirt1/Nrf2/GPX4 signaling pathway. [Abstract]

2026 Jun 22:605:91-107. PMID: 41999934
Neuroscience

Trichostatin A-primed spinal cord organoids alleviate oxidative stress and improve recovery after spinal cord injury involving the NRF2/HO-1 signaling pathway. [Abstract]

2026 Jun 6:610:122-135. PMID: 42250855
J Integr Neurosci

Activation of the p62/Keap1/Nrf2 Pathway Protects Against Ferroptosis in Cerebral Ischemia-Reperfusion Injury. [Abstract]

2026 May 26;25(5):48011. PMID: 42216635
Chem Biol Drug Des

Forsythiaside A Ameliorates Oxidative Damage Caused by Cerebral Ischemia Through the Nrf2/HO-1 Signaling Pathway. [Abstract]

2025 Mar;105(3):e70083. PMID: 40035314
Neuroscience

RBM3 Ameliorates Acute Brain Injury-induced Inflammation and Oxidative Stress by Stabilizing GAS6 mRNA Through Nrf2 Signaling Pathway. [Abstract]

2024 May 24:547:74-87. PMID: 38555015
Chem Biol Drug Des

Icaritin activates Nrf2/Keap1 signaling to protect neuronal cells from oxidative stress. [Abstract]

2021 Jan;97(1):111-120. PMID: 32654377
Animals (Basel)

Forsythiaside A Alleviates LPS-Induced Mastitis by Inhibiting Ferroptosis and Oxidative Stress. [Abstract]

2026 Jun 5;16(11):1750. PMID: 42278181
Mol Biol Rep

Oncogenic MAGEA4 directs neuroendocrine differentiation and survival in prostate cancer cells through the SIRT1/Acetyl-p53/BCL-2 axis. [Abstract]

2026 May 5;53(1):710. PMID: 42084830
IUBMB Life

OTUD1 Relieves Coxsackievirus-Induced Ferroptosis and Inflammation in Myocardial Cells by Stabilizing NRF2 and Inhibiting NF-κB Signaling. [Abstract]

2026 Mar;78(3):e70094. PMID: 41853919
Animals (Basel)

2026 Jan;16(11):1602.
Mol Biol Rep

Inhibition of ACSL6 ameliorates atherosclerosis by suppressing macrophage ferroptosis via the Nrf2 pathway. [Abstract]

2025 Nov 6;53(1):53. PMID: 41196445
Mol Biotechnol

Exosomal LncRNA MALAT1 Derived from Hepatocytes in Nonalcoholic Fatty Liver Disease Regulates the miR-579-3p/Keap1/Nrf2 Pathway to Exacerbate Obstructive Sleep Apnea Syndrome. [Abstract]

2025 Sep 4. PMID: 40906321
BMC Gastroenterol

Irisin prevents liver injury during exhausting physical activity by suppressing ferroptosis via Nrf2/GPX4 signaling. [Abstract]

2025 Jul 11;25(1):516. PMID: 40646495
Mol Biotechnol

Curcumin Inhibits Lipopolysaccharide-Induced Inflammation Through the HMGB1/NF-κB Signaling Pathway to Promote the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells. [Abstract]

2025 May 1. PMID: 40310592
Mol Biotechnol

Berberine Alleviates the Damage, Oxidative Stress and Mitochondrial Dysfunction of PC12 Cells Induced by High Glucose by Activating the KEAP1/Nrf2/ARE Pathway. [Abstract]

2023 Oct;65(10):1632-1643. PMID: 36737555
Mol Biol Rep

Cannabinoid type 2 receptor activation inhibits MPP+-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway. [Abstract]

2023 May;50(5):4423-4433. PMID: 36977807
Chin J Integr Med

Electroacupuncture Enhances Effectiveness of Omeprazole in Indomethacin-Induced Gastric Injury Mice via Nrf2 Activation and Vagus Nerve Conduction. [Abstract]

2026 Apr 1. PMID: 41920261
Free Radic Res

Melatonin inhibits liver ferroptosis in copper-laden rats: a potential therapy mechanism underlying Wilson's disease. [Abstract]

2025 Oct-Dec;59(10-12):797-814. PMID: 41273307
Tissue Cell

Tempol suppresses ferroptosis and relieves chronic intermittent hypoxia-induced lung injury through the inhibition of TLR4 and activation of the Nrf2/GSH axis. [Abstract]

2026 Feb:98:103225. PMID: 41232311
Chin J Integr Med

Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway. [Abstract]

2025 Feb;31(2):118-130. PMID: 39671057
Kaohsiung J Med Sci

ELAVL1-dependent SOAT2 exacerbated the pancreatitis-like cellular injury of AR42J cells induced by hyperstimulation with caerulein. [Abstract]

2025 Jan;41(1):e12911. PMID: 39588852
Kaohsiung J Med Sci

HMGB1 inhibition blocks ferroptosis and oxidative stress to ameliorate sepsis-induced acute lung injury by activating the Nrf2 pathway. [Abstract]

2024 Aug;40(8):710-721. PMID: 38837857
Cell Biochem Biophys

Impairing Ferroptosis Through the PI3K/Akt/Nrf2 Pathway: The Way for Nerve Growth Factor to Mitigate Hypoxia-induced Cardiomyocyte Damage. [Abstract]

2025 Jun;83(2):2023-2033. PMID: 39549229
Histochem Cell Biol

Blocking triggering receptors expressed on myeloid cell-1 alleviates alveolar epithelial cell senescence by inhibiting oxidative stress in pulmonary fibrosis. [Abstract]

2025 Apr 16;163(1):45. PMID: 40240638
BMC Nephrol

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway. [Abstract]

2025 Jan 30;26(1):45. PMID: 39885380
Fitoterapia

Ganweikang extract protects hepatocytes from oxidative injury by activating Nrf2/HO-1 and MAPKs pathways. [Abstract]

2024 Oct:178:106146. PMID: 39089591
Appl Sci

2024 Apr 10, 14(8), 3186.
Microvasc Res

Catalpol alleviates myocardial ischemia reperfusion injury by activating the Nrf2/HO-1 signaling pathway. [Abstract]

2022 Mar:140:104302. PMID: 34919942
Theriogenology

Nrf2 activation mediates the protection of mouse Sertoli Cells damage under acute heat stress conditions. [Abstract]

2022 Jan 1:177:183-194. PMID: 34715543
Toxicon

Astragaloside IV: a natural shield against ochratoxin A-induced hepatotoxicity in chicks by targeting the NRF2/NLRP3 signaling pathway. [Abstract]

2025 Nov:266:108513. PMID: 40780305
PLoS One

Alpinetin protects against iron overload related osteoarthritis via NRF2/HO-1 pathway. [Abstract]

2025 Jun 2;20(6):e0317930. PMID: 40455747
PLoS One

SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress. [Abstract]

2025 Mar 31;20(3):e0310879. PMID: 40163430
Hum Cell

Cl-amidine attenuates lipopolysaccharide-induced inflammation in human gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways. [Abstract]

2023 Jan;36(1):223-233. PMID: 36352311
Vet Sci

Meloxicam Alleviates Oxidative Stress Through Nrf2/HO-1 Activation in Bovine Endometrial Epithelial Cells. [Abstract]

2025 Jun 12;12(6):579. PMID: 40559816
Immunol Res

Echinocystic acid ameliorates ischemic acute kidney injury in neonatal rats by attenuating ferroptosis via the Nrf2/GPX4 pathway. [Abstract]

2025 Mar 11;73(1):58. PMID: 40067558
Shock

Hydromorphone mitigates cardiopulmonary bypass-induced acute lung injury by repressing pyroptosis of alveolar macrophages. [Abstract]

2023 Jul 1;60(1):92-99. PMID: 37127893
Toxicol In Vitro

Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway. [Abstract]

2020 Feb:62:104715. PMID: 31698019
Clin Res Hepatol Gastroenterol

Interleukin-22 ameliorates alcohol-associated liver fibrosis via Nrf2-ARE signaling: mechanistic insights and clinical correlations. [Abstract]

2025 Jul-Aug;49(7):102617. PMID: 40449584
J Chem Neuroanat

Ozone-Mediated Cerebral Protection: Unraveling the Mechanism through Ferroptosis and the NRF2/SLC7A11/GPX4 Signaling Pathway. [Abstract]

2024 Mar:136:102387. PMID: 38182039
Biochem Biophys Res Commun

Astragaloside II-preconditioned bone marrow mesenchymal stem cells attenuate sepsis-induced acute lung injury by restoring mitochondrial function via NRF2/PGC-1α pathway activation. [Abstract]

2026 Jun 15:829:154148. PMID: 42349124
Biochem Biophys Res Commun

Network pharmacology, molecular docking and experimental study on the mechanism of Curcumin's anti-ferroptosis in melanocytes. [Abstract]

2024 Dec 3:736:150871. PMID: 39461013
Biochem Biophys Res Commun

Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis. [Abstract]

2024 Jan 22:693:149324. PMID: 38101001
Biochem Biophys Res Commun

Protein arginine methyltransferase-1 deficiency restrains depression-like behavior of mice by inhibiting inflammation and oxidative stress via Nrf-2. [Abstract]

2019 Oct 20;518(3):430-437. PMID: 31492498
Biochem Biophys Res Commun

DUSP14 rescues cerebral ischemia/reperfusion (IR) injury by reducing inflammation and apoptosis via the activation of Nrf-2. [Abstract]

2019 Feb 12;509(3):713-721. PMID: 30638656
Radiat Res

Cytoplasmic Radiation Induced Radio-Adaptive Response in Human Lung Fibroblast WI-38 Cells. [Abstract]

2020 Sep 16;194(3):288-297. PMID: 32942306
Exp Ther Med

Exploring the protective mechanisms and therapeutic potential of carnosic acid against acute respiratory distress syndrome through molecular docking, molecular dynamics and experimental verification. [Abstract]

2026 Jan 28;31(3):83. PMID: 41668995
Vet Res Commun

Polyunsaturated fatty acids, vitamin E and lycopene alleviate ambient particulate matter organic extracts-induced oxidative stress in canine lung cells via the Nrf2/HO-1 pathway. [Abstract]

2023 Jun;47(2):791-801. PMID: 36456856
Exp Ther Med

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke. [Abstract]

2021 Jun;21(6):647. PMID: 33968178
Blood Cells Mol Dis

Propofol attenuates H2O2-induced senescence in human umbilical vein endothelial cells by activating the NRF2/HO-1 axis. [Abstract]

2026 Jun 7:120:103021. PMID: 42341456
Can Respir J

2024 Oct 27.
BMC Ophthalmol

Maresin-1 inhibits high glucose induced ferroptosis in ARPE-19 cells by activating the Nrf2/HO-1/GPX4 pathway. [Abstract]

2023 Sep 6;23(1):368. PMID: 37674121
In Vitro Cell Dev Biol Anim

HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway. [Abstract]

2024 Sep;60(8):868-878. PMID: 38807023
Nephrology (Carlton)

Rehmapicrogenin attenuates lipopolysaccharide-induced podocyte injury and kidney dysfunctions by regulating nuclear factor E2-related factor 2/antioxidant response element signalling. [Abstract]

2024 Aug;29(8):482-494. PMID: 38837564
Neurol Res

Melatonin regulates the MST1/Nrf2 pathway to alleviate oxidative stress injury after hypoxic-ischemic brain damage in neonatal rats. [Abstract]

2025 Nov 28:1-14. PMID: 41312691
Stem Cells Dev

Human Neural Stem Cell Secretome Inhibits Neuron Heme Uptake and Ferroptosis in Intracerebral Hemorrhage through Nrf-2 Signaling Pathway. [Abstract]

2023 Jun;32(11-12):346-363. PMID: 36960702
J Med Food

Luteolin Modulates the NF-E2-Related Factor 2/Glutamate-Cysteine Ligase Pathway in Rats with Spinal Cord Injury. [Abstract]

2021 Mar;24(3):218-225. PMID: 33739882
Am J Transl Res

Effects of Nrf-2 expression in trophoblast cells and vascular endothelial cells in preeclampsia. [Abstract]

2021 Mar 15;13(3):1006-1021. PMID: 33841636
Naturwissenschaften

Gamma-aminobutyric acid attenuates cortisol-induced damage in human colorectal adenocarcinoma cells via Nrf2 signaling. [Abstract]

2025 Oct 20;112(6):82. PMID: 41114738
Reprod Domest Anim

Arbutin Preserves Boar Sperm During Storage at 17°C by Enhancing the Antioxidant Capacity via the NRF2/GPX4 Signalling. [Abstract]

2025 Aug;60(8):e70103. PMID: 40718990
Curr Eye Res

MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 Signaling. [Abstract]

2024 Jun;49(6):591-604. PMID: 38450708
Rev Bras Farmacogn

2023 Aug 14.
Acta Cir Bras

Corynoline alleviates renal ischemia-reperfusion injury by enhancing Nrf2/HO-1 pathway. [Abstract]

2025 Aug 18:40:e406825. PMID: 40834223
Transpl Immunol

Sulforaphane alleviates hepatic ischemia-reperfusion injury through promoting the activation of Nrf-2/HO-1 signaling. [Abstract]

2021 Oct:68:101439. PMID: 34320386
Brain Inj

Mechanism of HDAC2 regulating Nrf2 acetylation level in neuronal ferroptosis of neonatal rats with hypoxic-ischemic brain injury. [Abstract]

2025;39(8):635-645. PMID: 40065544
Nat Prod Commun

2023 Aug 16.
Int J Dev Neurosci

Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane-Exposed Neonatal Mice. [Abstract]

2026 Apr;86(2):e70123. PMID: 41956473
Bratisl Lek Listy

2025 Apr 10;126:1264-1277.
J Vis Exp

Neuronal Ferroptosis Attenuation by RKIP Inhibition Following Spontaneous Intracerebral Hemorrhage via NRF2/HO-1 Pathway Activation. [Abstract]

2025 Oct 31:(224). PMID: 41247931
Biomed Pharmacother

Enhanced efficacy of methyl ferulate upon pentanoylation in ameliorating psoriasis via Nrf2/NF-κB pathway regulation and HDACs downregulation. [Abstract]

2026 Jul:200:119638. PMID: 42269223
Res Sq

2026 Jun 21.
SSRN

2026 Jun 2.
SSRN

2026 Apr 9.
bioRxiv

2026 Jan 26.
Environ Toxicol

Intranasal Curcumin and N-Acetyl l-Cysteine (NAC) Attenuates Dibutyl Phthalate (DBP)-Aggravated Airway Inflammation by Targeting Ferroptosis via Nrf-2/GPx4-SLC7A11. [Abstract]

2026 Jan 8. PMID: 41504138
Res Sq

2026 Jan 13.
Res Sq

2025 Oct 28.
News of Biomedical Sciences

2025.
SSRN

2025 Aug 7.
SSRN

2025 Jul 2.
SSRN

2025 May 8.
Res Sq

2025 Apr 25.
Authorea

2025 Apr 18.
J Appl Biol Chem

2025;68:16:114-122
bioRxiv

2025 March 11.
SSRN

2025 Mar 19.
bioRxiv

Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism. [Abstract]

2025 Feb 25:2025.02.19.638943. PMID: 40060410
bioRxiv

2024 November 03.
Res Sq

2024 Nov 27.
Res Sq

2024 Sep 08.
SSRN

2024 Aug 15.
Heliyon

LncRNA OIP5-AS1 regulates ferroptosis and mitochondrial dysfunction-mediated apoptosis in spinal cord injury by targeting the miR-128-3p/Nrf2 axis. [Abstract]

2024 Sep 10;10(18):e37704. PMID: 39309798
Heliyon

NBQX mediates ventricular fibrillation susceptibility in rat models of anxiety via the Nrf2/HO-1 pathway. [Abstract]

2024 Sep 3;10(17):e37358. PMID: 39296140
Biomed Pharmacother

Hecogenin alleviates LPS-induced osteolysis via regulating pyroptosis and ROS involved Nrf2 activation. [Abstract]

2024 Aug:177:116933. PMID: 38901204
bioRxiv

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors. [Abstract]

2024 Jun 28:2024.06.24.600383. PMID: 38979166
Preprints

2024 Apr 15.
bioRxiv

2024 Mar 11.
Sci Total Environ

PM2.5 exposure exacerbates seizure symptoms and cognitive dysfunction by disrupting iron metabolism and the Nrf2-mediated ferroptosis pathway. [Abstract]

2024 Feb 1:910:168578. PMID: 37981141
SSRN

2024 Jan 18.
Biomed Pharmacother

Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway. [Abstract]

2023 Dec 31:169:115937. PMID: 38007934
Research Square Preprint

2023 Dec 11.
Biomed Pharmacother

Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3. [Abstract]

2023 Nov:167:115618. PMID: 37793277
Biomed Pharmacother

CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress. [Abstract]

2023 Oct:166:115399. PMID: 37657258
Research Square Preprint

2023 Oct 19.
Research Square Preprint

2023 Oct 28.
Biomed Pharmacother

Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy. [Abstract]

2023 Aug:164:114897. PMID: 37224754
SSRN

2023 Jun 19.
Patent

US20230068698A1.
Research Square Print

2023 Feb 1.
Research Square Print

December 14th, 2022.
Evid Based Complement Alternat Med

NBP Relieves Cardiac Injury and Reduce Oxidative Stress and Cell Apoptosis in Heart Failure Mice by Activating Nrf2/HO-1/Ca2+-SERCA2a Axis. [Abstract]

2022 Nov 21:2022:7464893. PMID: 36452141
Research Square Print

October 14th, 2022.
Biomed Pharmacother

Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis. [Abstract]

2022 Oct:154:113572. PMID: 35988428
Biomed Pharmacother

Extract of Jasminum grandiflorum L. alleviates CCl4-induced liver injury by decreasing inflammation, oxidative stress and hepatic CYP2E1 expression in mice. [Abstract]

2022 Aug;152:113255. PMID: 35689859
Research Square Print

September 15th, 2022.
Research Square Print

2022 May.
Oxid Med Cell Longev

COX-2/sEH Dual Inhibitor PTUPB Attenuates Epithelial-Mesenchymal Transformation of Alveolar Epithelial Cells via Nrf2-Mediated Inhibition of TGF- β 1/Smad Signaling. [Abstract]

2022 Apr 25;2022:5759626. PMID: 35509835
Oxid Med Cell Longev

The Novel Nrf2 Activator Omaveloxolone Regulates Microglia Phenotype and Ameliorates Secondary Brain Injury after Intracerebral Hemorrhage in Mice. [Abstract]

2022 Mar 11:2022:4564471. PMID: 35308167
Research Square Preprint

2022 Feb.
Oxid Med Cell Longev

Eugenol-Preconditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Antioxidant Capacity of Tendon Stem Cells In Vitro and In Vivo. [Abstract]

2022 Feb 8;2022:3945195. PMID: 35178155
Oxid Med Cell Longev

Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury. [Abstract]

2022 Feb 1:2022:1337630. PMID: 35154562
Chemrxiv

Feb 03, 2022.
Bioengineered

Carvedilol activates nuclear factor E2-related factor 2/ antioxidant response element pathway to inhibit oxidative stress and apoptosis of retinal pigment epithelial cells induced by high glucose. [Abstract]

2022 Jan;13(1):735-745. PMID: 34898371
Evid Based Complement Alternat Med

Tianxiangdan Improves Coronary Microvascular Dysfunction in Rats by Inhibiting Microvascular Inflammation via Nrf2 Activation. [Abstract]

2021 Dec 2:2021:4114784. PMID: 34899948
Oxid Med Cell Longev

Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway. [Abstract]

2021 Dec 31;2021:9426314. PMID: 35003522
Research Square Preprint

2021 Oct.
Oxid Med Cell Longev

Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway. [Abstract]

2021 Sep 29:2021:2637577. PMID: 34630847
Research Square Preprint

2021 Sep.
Research Square Preprint

2021 Aug.
Oxid Med Cell Longev

κ Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca2+-SERCA2a. [Abstract]

2021 Jul 30:2021:7328437. PMID: 34373768
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 May.
Ann Transl Med

Itaconate ameliorates methicillin-resistant Staphylococcus aureus-induced acute lung injury through the Nrf2/ARE pathway. [Abstract]

2021 Apr;9(8):712. PMID: 33987410
Research Square Preprint

2020 Dec.
Oxid Med Cell Longev

Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NF κ B Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice. [Abstract]

2020 Nov 3:2020:9734560. PMID: 33204402
Evid Based Complement Alternat Med

Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs. [Abstract]

2020 Aug 15:2020:5172765. PMID: 32879632
Oxid Med Cell Longev

Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway. [Abstract]

2020 Jul 27:2020:8291413. PMID: 32774686
Aging (Albany NY)

Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells. [Abstract]

2020 Apr 22;12(8):7534-7548. PMID: 32320383
Oxid Med Cell Longev

Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2. [Abstract]

2019 Nov 15:2019:4703253. PMID: 31827675
Oxid Med Cell Longev

KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo. [Abstract]

2019 Nov 19:2019:8564681. PMID: 31827706
Oxid Med Cell Longev

Protection against HEMA-Induced Mitochondrial Injury In Vitro by Nrf2 Activation. [Abstract]

2019 Apr 7:2019:3501059. PMID: 31089407

ML385 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2019 Apr 7:2019:3501059. [Abstract]

Western blot of Nrf2 and HO-1 protein expression levels with the treatment of HEMA, HEMA+BHQ, and HEMA+ML385.

ML385 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2019 Apr 7:2019:3501059. [Abstract]

Immunofluorescence analysis of Nrf2 expression and nuclear translocation. Green fluorescence represents Nrf2, and blue fluorescence represents nucleus of hDPCs. Data represent mean ± standard deviations (n = 3).
Oxid Med Cell Longev

Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3 β/Nrf2 Signaling Pathway and Inhibiting the NF- κ B Signaling Pathway in 5/6 Nephrectomized Rats. [Abstract]

2019 Mar 18:2019:2853534. PMID: 31011401

ML385 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2019 Mar 18:2019:2853534. [Abstract]

The protein expression levels of Nrf2 (nucleus), Nrf2 (cytoplasm), HO-1, p-NF-κB p65, NF-κB p65, and ICAM-1 proteins are analyzed by Western blot with or without the treatment of H₂O₂, SAA and ML385.
Oxid Med Cell Longev

Prevention of Huntington's Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress. [Abstract]

2019 Mar 26:2019:4032428. PMID: 31049134
Oxid Med Cell Longev

Proanthocyanidins Antagonize Arsenic-Induced Oxidative Damage and Promote Arsenic Methylation through Activation of the Nrf2 Signaling Pathway. [Abstract]

2019 Jan 20:2019:8549035. PMID: 30805085
Aging (Albany NY)

Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway. [Abstract]

2018 Aug 16;10(8):2016-2036. PMID: 30115814

ML385 purchased from MedChemExpress. Usage Cited in: Aging (Albany NY). 2018 Aug 16;10(8):2016-2036. [Abstract]

Relative changes in the expression of Nrf2, pNrf2 and HO-1 after treatment with D-gal, ML385 alone or combined with lycopene.
Oxid Med Cell Longev

Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO-1 Pathway. [Abstract]

2018 Apr 26:2018:7161592. PMID: 29854090

Solvant et solubilité

In Vitro:

DMSO : 25 mg/mL (48.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9547 mL

9.7735 mL

19.5469 mL

5 mM

0.3909 mL

1.9547 mL

3.9094 mL

10 mM

0.1955 mL

0.9773 mL

1.9547 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2 mg/mL (3.91 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

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COA (2659 KB)
Elemental Analysis Report (2659 KB)
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Références

[1]. Singh A, et al. Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. ACS chemical biology. 2016 Nov 18;11(11):3214-3225. [Content Brief]

[2]. Ji L, et al. The NRF2 antagonist ML385 inhibits PI3K-mTOR signaling and growth of lung squamous cell carcinoma cells. Cancer medicine. 2023 Mar;12(5):5688-5702.

[3]. Yan L, et al. ML385 promotes ferroptosis and radiotherapy sensitivity by inhibiting the NRF2-SLC7A11 pathway in esophageal squamous cell carcinoma. Medical oncology (Northwood, London, England). 2024 Nov 07;41(12):309. [Content Brief]

[4]. Ishikawa C, et al. ML385, a selective inhibitor of Nrf2, demonstrates efficacy in the treatment of adult T-cell leukemia. Leukemia & lymphoma. 2025 Apr;66(4):721-732.

[5]. Jeong EJ, et al. The Effects of ML385 on Head and Neck Squamous Cell Carcinoma: Implications for NRF2 Inhibition as a Therapeutic Strategy. International journal of molecular sciences. 2024 Jun 27;25(13):7011.

[6]. Yuan J, et al. ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen. Naunyn-Schmiedeberg's archives of pharmacology. 2025 Nov;398(11):16081-16093. [Content Brief]

[7]. Xu C, et al. Cardioprotective effects of melatonin against myocardial ischaemia/reperfusion injury: Activation of AMPK/Nrf2 pathway. Journal of cellular and molecular medicine. 2021 Jun 14;25(13):6455-9.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9547 mL	9.7735 mL	19.5469 mL	48.8673 mL
	5 mM	0.3909 mL	1.9547 mL	3.9094 mL	9.7735 mL
	10 mM	0.1955 mL	0.9773 mL	1.9547 mL	4.8867 mL
	15 mM	0.1303 mL	0.6516 mL	1.3031 mL	3.2578 mL
	20 mM	0.0977 mL	0.4887 mL	0.9773 mL	2.4434 mL
	25 mM	0.0782 mL	0.3909 mL	0.7819 mL	1.9547 mL
	30 mM	0.0652 mL	0.3258 mL	0.6516 mL	1.6289 mL
	40 mM	0.0489 mL	0.2443 mL	0.4887 mL	1.2217 mL

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ML385

629 Cited Publications

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ML385

Brusatol

Sulforaphane

Omaveloxolone

TBHQ

Ferrostatin-1

Erastin

4-Octyl itaconate

KI696

Dimethyl fumarate

Rapamycin

Acetylcysteine

RSL3

Publications Citing Use of MedChemExpress (MCE) ML385

Voir tous les produits spécifiques à Isoform mTOR

Activité biologique

Chemical Information

Publications (629)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

ML385

Brusatol

Sulforaphane

Omaveloxolone

TBHQ

Ferrostatin-1

Erastin

4-Octyl itaconate

KI696

Dimethyl fumarate

Rapamycin

Acetylcysteine

RSL3

Publications Citing Use of MedChemExpress (MCE) ML385

Voir tous les produits spécifiques à Isoform mTOR

Activité biologique

Chemical Information

Publications (629)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

ML385 Related Classifications

HY-100523 Related Classifications

Bioz