MSOP
Based on 1 Customer Validation
MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.
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- Pureté : 98.0%
- CAS No.: 66515-29-5
- Formule: C4H10NO6P
- Masse moléculaire:199.10
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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L-AP4Group III mGluRs Agonist
Activité biologique
Description
IC50 & Target
KD: 51 μM (L-AP4-sensitive presynaptic mGluR)[1].
In Vitro
In the presence of 200 μM MSOP, a rightward parallel shift of the dose-response curve to L-AP4 is observed, with an apparent KD calculated as 51±6 μM (n=3). MSOP is shown to be selective for the L-APC sensitive presynaptic mGluR, the apparent KD for the interaction of MSOP with the (1S, 3S)-ACPD sensitive receptor calculated as greater than 700 μM (n=3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 66515-29-5
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Appearance Solid
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Masse moléculaire 199.10
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Formule C4H10NO6P
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Color White to off-white
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SMILES
NC(COP(O)(O)=O)(C)C(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
H2O : 62.5 mg/mL (313.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Thomas NK, et al. alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology. 1996 Jun;35(6):637-42. [Content Brief]
[2]. Myron Yaster, et al. Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund’s adjuvant. Anesthesiology. 2011 Feb; 114(2): 412–423. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0226 mL | 25.1130 mL | 50.2260 mL | 125.5650 mL |
| 5 mM | 1.0045 mL | 5.0226 mL | 10.0452 mL | 25.1130 mL | |
| 10 mM | 0.5023 mL | 2.5113 mL | 5.0226 mL | 12.5565 mL | |
| 15 mM | 0.3348 mL | 1.6742 mL | 3.3484 mL | 8.3710 mL | |
| 20 mM | 0.2511 mL | 1.2557 mL | 2.5113 mL | 6.2783 mL | |
| 25 mM | 0.2009 mL | 1.0045 mL | 2.0090 mL | 5.0226 mL | |
| 30 mM | 0.1674 mL | 0.8371 mL | 1.6742 mL | 4.1855 mL | |
| 40 mM | 0.1256 mL | 0.6278 mL | 1.2557 mL | 3.1391 mL | |
| 50 mM | 0.1005 mL | 0.5023 mL | 1.0045 mL | 2.5113 mL | |
| 60 mM | 0.0837 mL | 0.4186 mL | 0.8371 mL | 2.0928 mL | |
| 80 mM | 0.0628 mL | 0.3139 mL | 0.6278 mL | 1.5696 mL | |
| 100 mM | 0.0502 mL | 0.2511 mL | 0.5023 mL | 1.2557 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MSOP Related Classifications
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