Cat. No.: HY-N0668

Rubusoside

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase).

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Pureté: 98.05%
CAS No.: 64849-39-4
Formule: C₃₂H₅₀O₁₃
Masse moléculaire:642.73

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Rubusoside Chemical Structure

CAS No.: 64849-39-4

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Activité biologique
- Description
- Cellular Effect
- In Vivo
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform GLUT :

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
Raji	IC₅₀	450 μM Compound: 5	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique	[PMID: 19131254]

In Vivo

Rubusoside (50-300 mg/kg; po; single dose) exerts anti-inflammatory and antiasthmatic activities in an OVA-induced experimental allergic asthma mouse model. Moreover, Rubusoside inhibits OVA-induced activation of the NF-κB pathway in lung tissue^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ovalbumin‐induced mice allergic asthma model^[4]
Dosage:

50, 150, 300 mg/kg
Administration:

po; mixed with PBS (phosphate-buffered saline, pH 7.4) 1 hr before OVA treatment (intraperitoneal injected with 20 μg OVA and intranasal spray 1% OVA solution from Day 21 to Day 23)
Result:

Contributed to the decrease of inflammatory cytokines (TNF-α, IL-13, IL-6, IL-5, and IL-4) inside the BALF of mice with asthma.
Led a decline of OVA-dependent IgE and IgG1 inside the serum was also noticed in these mice.
Enhanced the mRNA level of Foxp3 inside the mice lung affected with asthma while decrease that of IL-17A, IL-23, and RORγt.

Chemical Information

CAS No. 64849-39-4
Appearance Solid
Masse moléculaire 642.73
Formule C₃₂H₅₀O₁₃
Color White to off-white
SMILES

C[C@]([C@]1([H])CC2)(CCC[C@@]1(C)C(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=O)[C@@]4([H])[C@]2(CC5=C)C[C@@]5(O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)CC4
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- other families
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Microbiol Spectr

Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]

2023 Sep 21;11(5):e0267123. PMID: 37732782
J Food Biochem

Rubusoside alleviates the ovalbumin-induced mice allergic asthma by modulating the NF-κB activation. [Abstract]

2020 May;44(5):e13187. PMID: 32185800

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (155.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5559 mL

7.7793 mL

15.5586 mL

5 mM

0.3112 mL

1.5559 mL

3.1117 mL

10 mM

0.1556 mL

0.7779 mL

1.5559 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.75 mg/mL (4.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.75 mg/mL (4.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.75 mg/mL (4.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (282 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang Z et al. Selective production of rubusoside from stevioside by using the sophorose activity of β-glucosidase from Streptomyces sp. GXT6. Appl Microbiol Biotechnol. 2015 Nov;99(22):9663-74. [Content Brief]

[2]. Ko JA et al. Mass production of rubusoside using a novel stevioside-specific β-glucosidase from Aspergillus aculeatus. J Agric Food Chem. 2012 Jun 20;60(24):6210-6. [Content Brief]

[3]. Zheng H, et al. Metabolomics analysis of the protective effect of rubusoside on palmitic acid-induced lipotoxicity in INS-1 cells using UPLC-Q/TOF MS. Mol Omics. 2019 Jun 1;15(3):222-232. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5559 mL	7.7793 mL	15.5586 mL	38.8966 mL
	5 mM	0.3112 mL	1.5559 mL	3.1117 mL	7.7793 mL
	10 mM	0.1556 mL	0.7779 mL	1.5559 mL	3.8897 mL
	15 mM	0.1037 mL	0.5186 mL	1.0372 mL	2.5931 mL
	20 mM	0.0778 mL	0.3890 mL	0.7779 mL	1.9448 mL
	25 mM	0.0622 mL	0.3112 mL	0.6223 mL	1.5559 mL
	30 mM	0.0519 mL	0.2593 mL	0.5186 mL	1.2966 mL
	40 mM	0.0389 mL	0.1945 mL	0.3890 mL	0.9724 mL
	50 mM	0.0311 mL	0.1556 mL	0.3112 mL	0.7779 mL
	60 mM	0.0259 mL	0.1297 mL	0.2593 mL	0.6483 mL
	80 mM	0.0194 mL	0.0972 mL	0.1945 mL	0.4862 mL
	100 mM	0.0156 mL	0.0778 mL	0.1556 mL	0.3890 mL

Keywords

Rubusoside

2 Cited Publications

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Rubusoside

Immunology/Inflammation Compound Library

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NF-κB Signaling Compound Library

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Publications Citing Use of MedChemExpress (MCE) Rubusoside

Voir tous les produits spécifiques à Isoform GLUT

Voir tous les produits spécifiques à Isoform NF-κB

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Rubusoside Related Classifications

HY-N0668 Related Classifications