Aerothionin
Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs).
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- CAS No.: 28714-26-3
- Formule: C24H26Br4N4O8
- Masse moléculaire:818.10
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
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[PMID: 17512741] |
| HeLa | EC50 |
42 μM
Compound: 17
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 24631731] |
| HeLa | IC50 |
29 μM
Compound: 2
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Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay
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[PMID: 33940466] |
| HT-29 | GI50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human HT29 cells by SRB assay
Cytotoxicity against human HT29 cells by SRB assay
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[PMID: 17512741] |
| MDA-MB-231 | GI50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human MDA-MB-231 cells by SRB assay
Cytotoxicity against human MDA-MB-231 cells by SRB assay
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[PMID: 17512741] |
In Vitro
Aerothionin (0-100 μM, 24h) inhibits prolifeartions of pheochromocytoma cells MPC and MTT, inhibits the MTT spheroid growth (10 μM, single dose)[1].
Aerothionin (0-100 μM, 24h) exhibits toxicity in normal endothelial cells HUVECs, stimulates slightly the viability of normal fibroblasts 3T3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MPC, MTT, HUVECs, 3T3
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Inhibited proliferations of MPC, MTT and HUVECs, stimulated proliferation of 32T3.
Chemical Information
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CAS No. 28714-26-3
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Masse moléculaire 818.10
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Formule C24H26Br4N4O8
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SMILES
O[C@@H]1[C@@]2(C=C(C(OC)=C1Br)Br)CC(C(NCCCCNC(C3=NO[C@@]4([C@H](C(Br)=C(C(Br)=C4)OC)O)C3)=O)=O)=NO2
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Structure Classification
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Initial Source
Aplysina fistularis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Drechsel A, et al., Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro. Mar Drugs. 2020 May 1;18(5):236. [Content Brief]
[2]. Šimovičová M. Synthesis of aerothionin analogs as potential antimycobacterial agents[J]. 2021.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aerothionin Related Classifications
HY-121349 Related Classifications
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