CD28-IN-3
CD28-IN-3 is a CD28 inhibitor with an IC50 of 7.80 μM and a Kd of 52.45 μM. CD28-IN-3 selectively blocks the CD28-B7 interaction, thereby inhibiting CD28-mediated costimulation. CD28-IN-3 suppresses the production of proinflammatory cytokines IFN-γ, IL-2 and TNF-α. CD28-IN-3 can be used in the research of checkpoint-resistant cancers.
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- CAS No.: 850550-70-8
- Formule: C17H24N4OS2
- Masse moléculaire:364.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
CD28-IN-3 (Compound 22VS) (0-100 μM; 2 h) inhibits the interactions of membrane-bound CD28-CD80 and CD28-CD86 in CHO-K1 cells, with corresponding submicromolar IC50 values of 1.48 μM and 1.39 μM, respectively[1].
CD28-IN-3 (10-300 μM; 24 h) shows no cytotoxicity against human Jurkat T lymphocytes even at concentrations up to 300 μM following a 24 h incubation[1].
CD28-IN-3 (0-200 μM; 5 h) inhibits CD28-mediated T cell costimulation in the Jurkat-Raji co-culture system, with an IC50 of 6.96 μM[1].
CD28-IN-3 (10-50 μM; 48 h) inhibits the release of CD28-dependent proinflammatory cytokines (IFN-γ, IL-2, TNF-α) in a dose-dependent manner in 3D A549 tumor-PBMC co-culture systems and human PBMC-mucosa co-culture systems[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human Jurkat T lymphocytes
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Concentration:10, 30, 100 and 300 μM
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Incubation Time:24 h (37°C)
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Result:Maintained cell viability above 85% at all tested concentrations, showing no measurable cytotoxicity.
Chemical Information
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CAS No. 850550-70-8
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Masse moléculaire 364.53
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Formule C17H24N4OS2
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SMILES
CCC(NC(CSC1=NN=C(S1)NC2=CC=C(C=C2)C(C)C)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CD28-IN-3 Related Classifications
HY-181507 Related Classifications
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