DC541
DC541 (Compound 20) is a selective NTMT1 inhibitor with an IC50 of 0.34 μM. DC541 reduces the level of me3-RCC1 in colorectal cancer cells. DC541 is applicable to research related to colorectal cancer.
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- CAS No.: 2606862-00-2
- Formule: C30H35N5O4
- Masse moléculaire:529.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Activité biologique
Description
In Vitro
DC541 potently inhibits purified NTMT1 with an IC50 of 0.34 μM[1].
DC541 (0.3-300 μM) inhibits the level of me3-RCC1 in colorectal cancer HT29 cells, with an IC50 of approximately 30 μM[1].
DC541 (0.3-300 μM) inhibits the level of me3-RCC1 in colorectal cancer HCT116 cells, with an IC50 of approximately 100 μM[1].
DC541 (up to 1 mM; 24-72 h) exerts no significant cytotoxicity against colorectal cancer HT29 and HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:human colorectal cancer HT29 and HCT116 cells
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Concentration:up to 1 mM
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Incubation Time:24-72 h
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Result:Showed no significant reduction in cell viability in HT29 cells at concentrations up to 1 mM across 24 h, 48 h, 72 h incubation time points.
Showed no significant reduction in cell viability in HCT116 cells at concentrations up to 1 mM across 24 h, 48 h, 72 h incubation time points.
Chemical Information
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CAS No. 2606862-00-2
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Masse moléculaire 529.63
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Formule C30H35N5O4
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SMILES
O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(NC2=C(C=CC=C2)C(N)=O)=O)=O)CC3=CC=CC4=C3C=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DC541 Related Classifications
HY-182676 Related Classifications
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