Ccl2 - chemokine (C-C motif) ligand 2 Gene

Also Known as JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20296

Summary

This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]

Ccl2 Products (1)

mRNA Protein Name
NM_011333.3 NP_035463.1 C-C motif chemokine 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables CCR2 chemokine receptor binding IPI
IPI: Inferred from physical interaction
8662823 MGI
enables G protein-coupled receptor binding IDA
IDA: Inferred from direct assay
8631787 MGI
enables cytokine activity IDA
IDA: Inferred from direct assay
23395675 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8631787 MGI
Biological Process GO Annotation Evidence Références Source
involved in cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
14662900 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
14662900 MGI
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
14662900 MGI
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
14662900 MGI
involved in helper T cell extravasation IDA
IDA: Inferred from direct assay
18586982 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
14566334 MGI
involved in positive regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
14662900 MGI
involved in positive regulation of apoptotic cell clearance IDA
IDA: Inferred from direct assay
20691665 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
30687013 MGI
involved in positive regulation of immune complex clearance by monocytes and macrophages IMP
IMP: Inferred from mutant phenotype
14566334 MGI
involved in positive regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
14566334 MGI
involved in positive regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
25651887 MGI
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
19164781 MGI
involved in positive regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
29993042 MGI
involved in regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
14566334 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within response to wounding IDA
IDA: Inferred from direct assay
19404405 MGI
involved in sensory perception of pain IDA
IDA: Inferred from direct assay
29993042 MGI
Cellular Component GO Annotation Evidence Références Source
located in extracellular space IDA
IDA: Inferred from direct assay
19139201 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-C motif chemokine 2

  • monocyte chemoattractant protein 1

  • monocyte chemotactic protein 1

  • platelet-derived growth factor-inducible protein JE

  • small-inducible cytokine A2

Recombinant Ccl2 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P7235 MCP-1/CCL2 Protein, Mouse (HEK293) P10148 (Q24-R96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7764 MCP-1/CCL2 Protein, Mouse P10148 (Q24-R96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72757 MCP-1/CCL2 Protein, Mouse (HEK293, His) P10148 (Q24-N148) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74758 MCP-1/CCL2 Protein, Mouse (sf9, His) Q5SVU3 (Q24-N148) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P76489 MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) Q5SVU3 (Q24-N148) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700164AF Animal-Free MCP-1/CCL2 Protein, Mouse (His) P10148 (Q24-N148) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-B0673 Pirfenidone Inhibitor 99.99% Yes
HY-B1322A Amodiaquine 99.92% Unkown
HY-B1322 Amodiaquine dihydrochloride dihydrate 99.97% Unkown
HY-B1203 Fludrocortisone 98.99% Yes
HY-B1322B Amodiaquine dihydrochloride 99.97% Unkown
HY-B0673R Pirfenidone (Standard) Inhibitor 99.97% Unkown
HY-B1076 Medrysone 99.79% Unkown
HY-B1203R Fludrocortisone (Standard) / Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit Effect
Pureté Phase
HY-B0498 Bindarit Inhibitor 99.59% Phase 3
HY-B0673S1 Deupirfenidone 99.93% Phase 3
HY-165528 Histamine glutarimide Inhibitor / Phase 3
HY-148100A Emapticap pegol sodium Inhibitor 91.38% Phase 2
Inhibitory Antibodies (3)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P99188 Carlumab Inhibitor 97.80% Phase 2
HY-P99450 Avdoralimab Inhibitor 99.25% Phase 2
HY-P99781 Plozalizumab Inhibitor 99.53% Phase 2

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-W007376 Indole-3-carboxaldehyde 99.96% Unkown
HY-120501 B022 Inhibitor 99.27% Unkown
HY-115644 BMS-470539 dihydrochloride Agonist 99.85% Unkown
HY-120897 NS-3-008 hydrochloride Inhibitor 99.67% Unkown
HY-160552 244cis 99.67% Unkown
HY-116247 ST247 Agonist 99.88% Unkown
HY-N0444 Rubiadin 99.20% Unkown
HY-B0673S Pirfenidone-d5 Inhibitor 98.88% Unkown
HY-170415 EGR-1-IN-3 Inhibitor 99.13% Unkown
HY-W013675 2-Methoxyhydroquinone Pre-designed Set 99.57% Unkown
HY-NP192 Sericin 0% Unkown
HY-148100 Emapticap pegol Inhibitor 91.38% Unkown
HY-149202 UT-11 Inhibitor 98.25% Unkown
HY-P11553A ECL1i TFA Inhibitor 97.36% Unkown
HY-RS02089 CCL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16514 Ccl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B1203S Fludrocortisone-d5 / Unkown
HY-108554 Q94 hydrochloride Antagonist / Unkown
HY-121896 DSHN Activator / Unkown
HY-144334 CHIKV-IN-3 Inhibitor / Unkown
HY-163655 Glutaminyl Cyclase Inhibitor 6 Inhibitor / Unkown
HY-171680 Anti-CCL2 (Carlumab)-SMCC-DM1 / Unkown
HY-171681 Anti-CCL2 (Carlumab)-SPDB-DM4 / Unkown
HY-171682 Anti-CCL2 (Carlumab)-McMMAF / Unkown
HY-171683 Anti-CCL2 (Carlumab)-VcMMAE / Unkown
HY-171684 Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38 / Unkown
HY-171685 Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA / Unkown
HY-171895 12-Nitrolinoleate / Unkown
HY-173518 SIN 14 / Unkown
HY-176255 TBK1 degrader-4 Inhibitor / Unkown
HY-178926 RAGE406R Inhibitor / Unkown
HY-180831 BRD4 D1-IN-3 Inhibitor / Unkown
HY-185153 MC-VC-PAB-DMEA-PEG2-Duocarmycin SA / Unkown
HY-B1203S1 Fludrocortisone-d2 / Unkown
HY-B1322AS1 Amodiaquine-d10 hydrochloride / Unkown
HY-N3887 Evoxine Inhibitor / Unkown
HY-P11553 ECL1i Inhibitor / Unkown
HY-W104821 Rosolic acid Activator / Unkown
HY-168782 Resolvin D2 n-3 DPA Inhibitor / Unkown
HY-174763 Human CCL2 mRNA / Unkown
HY-177933 mNOX-E36 Inhibitor / Unkown
HY-183423 MK256 Inhibitor / Unkown
HY-RS22945 Ccl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990297 Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) Inhibitor 99.5% Unkown
HY-P99149 Anti-Mouse TNFR2 Antibody (TR75-54.7) Inhibitor 98.864% Unkown
HY-P991280 BMS-981164 Inhibitor 95.36% Unkown
HY-P991208 Flt-3L-Ig (hum/hum) 98% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl2 NCBI NCBI:6347