SLC7A1 - solute carrier family 7 member 1 Gene

Also Known as ERR; ATRC1; CAT-1; HCAT1; REC1L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6541

About SLC7A1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:29,509,414-29,595,688 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 22.4), brain (RPKM 11.3) and 24 other tissues.

Summary

Enables L-arginine transmembrane transporter activity and L-histidine transmembrane transporter activity. Involved in amino acid transport. Located in membrane. Part of apical plasma membrane; basolateral plasma membrane; and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A1 Products (1)

mRNA	Protein	Name
NM_003045.5	NP_003036.1	high affinity cationic amino acid transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables L-arginine transmembrane transporter activity	IDA IDA: Inferred from direct assay	9174363	GOA
enables L-arginine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	26449889	GOA
enables L-histidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	11591158	GOA
enables L-lysine transmembrane transporter activity	IDA IDA: Inferred from direct assay	10485994	GOA
enables amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	28684763	GOA
enables basic amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	11891586	GOA
enables basic amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	17197568	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in L-amino acid transport	IDA IDA: Inferred from direct assay	28684763	GOA
involved in L-arginine transmembrane transport	IDA IDA: Inferred from direct assay	9174363	GOA
involved in L-arginine transmembrane transport	IMP IMP: Inferred from mutant phenotype	26449889	GOA
involved in L-histidine import across plasma membrane	IDA IDA: Inferred from direct assay	11591158	GOA
involved in amino acid import across plasma membrane	IDA IDA: Inferred from direct assay	28684763	GOA
involved in lysine transport	IDA IDA: Inferred from direct assay	11891586	GOA
involved in ornithine transport	IMP IMP: Inferred from mutant phenotype	17197568	GOA
acts upstream of positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	26449889	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	31791063	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11891586	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	28112518	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28246125	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A1 Protein Structure

AA_permease_2

AA_permease_C

0
100
200
300
400
500
600
629 a.a.

Protein Preferred Names	Protein Names
high affinity cationic amino acid transporter 1	CAT1

SLC7A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SLC7A1	P30825	CCL4L1	Homo sapiens	Q8NHW4	Validated Y2H	32296183
Intra	SLC7A1	P30825	TMBIM6	Homo sapiens	P55061	Validated Y2H	32296183
Intra	SLC7A1	P30825	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	SLC7A1	P30825	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC7A1	P30825	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	SLC7A1	P30825	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	SLC7A1	P30825	MS4A13	Homo sapiens	Q5J8X5	Validated Y2H	32296183
Intra	SLC7A1	P30825	FAM241B	Homo sapiens	Q96D05-2	Validated Y2H	32296183
Intra	SLC7A1	P30825	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	SLC7A1	P30825	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	SLC7A1	P30825	SLC52A1	Homo sapiens	Q9NWF4	Validated Y2H	32296183
Intra	SLC7A1	P30825	ST6GAL2	Homo sapiens	Q96JF0-2	Validated Y2H	32296183
Intra	SLC7A1	P30825	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SLC7A1	P30825	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	SLC7A1	P30825	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SLC7A1	P30825	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	SLC7A1	P30825	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	PDCD1LG2	Homo sapiens	Q9BQ51	Validated Y2H	32296183
Intra	SLC7A1	P30825	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	SLC7A1	P30825	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	SLC7A1	P30825	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	SLC7A1	P30825	SLC18A2	Homo sapiens	Q05940	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	SLC18A2	Homo sapiens	Q05940	Y2H Array	32296183
Intra	SLC7A1	P30825	SLC18A2	Homo sapiens	Q05940	Validated Y2H	32296183
Intra	SLC7A1	P30825	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	SLC7A1	P30825	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	SLC7A1	P30825	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	SLC7A1	P30825	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	CMTM2	Homo sapiens	Q8TAZ6	Validated Y2H	32296183
Intra	SLC7A1	P30825	CMTM2	Homo sapiens	Q8TAZ6	Y2H Array	32296183
Intra	SLC7A1	P30825	CMTM2	Homo sapiens	Q8TAZ6	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	RNF144A	Homo sapiens	P50876	Validated Y2H	32296183
Intra	SLC7A1	P30825	RNF144A	Homo sapiens	P50876	Y2H Array	32296183
Intra	SLC7A1	P30825	RNF144A	Homo sapiens	P50876	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	SLC7A1	P30825	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	SLC7A1	P30825	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	SLC7A1	P30825	EMC6	Homo sapiens	Q9BV81	Validated Y2H	32296183
Intra	SLC7A1	P30825	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	SLC7A1	P30825	HERPUD2	Homo sapiens	Q9BSE4	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	HERPUD2	Homo sapiens	Q9BSE4	Validated Y2H	32296183
Intra	SLC7A1	P30825	HERPUD2	Homo sapiens	Q9BSE4	Y2H Array	32296183
Intra	SLC7A1	P30825	SACM1L	Homo sapiens	Q9NTJ5	Validated Y2H	32296183
Intra	SLC7A1	P30825	GALNT15	Homo sapiens	Q8N3T1	Validated Y2H	32296183
Intra	SLC7A1	P30825	STIM1	Homo sapiens	Q13586	Validated Y2H	32296183
Intra	SLC7A1	P30825	STIM1	Homo sapiens	Q13586	Y2H Array	32296183
Intra	SLC7A1	P30825	STIM1	Homo sapiens	Q13586	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	SLC7A1	P30825	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SLC7A1	P30825	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SLC7A1	P30825	ORMDL3	Homo sapiens	Q8N138	Validated Y2H	32296183
Intra	SLC7A1	P30825	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	SLC7A1	P30825	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	SLC7A1	P30825	PTPN9	Homo sapiens	P43378	Validated Y2H	32296183
Intra	SLC7A1	P30825	PTPN9	Homo sapiens	P43378	Y2H Array	32296183
Intra	SLC7A1	P30825	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	SLC7A1	P30825	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	SLC7A1	P30825	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
Intra	SLC7A1	P30825	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	SLC7A1	P30825	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
Intra	SLC7A1	P30825	YIPF4	Homo sapiens	Q9BSR8	Anti Tag CoIP	28514442
Intra	SLC7A1	P30825	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	32296183
Intra	SLC7A1	P30825	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SLC7A1	P30825	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SLC7A1	P30825	SEC23A	Homo sapiens	Q15436	Validated Y2H	32296183
Intra	SLC7A1	P30825	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	SLC7A1	P30825	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	SLC7A1	P30825	PNLIPRP1	Homo sapiens	P54315	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC7A1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P89648	CAT-1 Antibody (YA8992)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Aids Phobia
Tinea Capitis	Dermatophytosis Of Scalp Scalp Ringworm Dermatophytosis Of Scalp Or Beard Tinea Capitis Due To Trichophyton Rubrum Trichophyton Rubrum Tinea Capitis
Decubitus Ulcer	Pressure Ulcer Pressure Sores Pressure Ulcers Bedsore Decubitus Ulcer Decubitus Ulcer Any Site
Prolapse Of Urethra	Urethrocele
Chronic Ulcer Of Skin	Chronic Wounds Callous Ulcer Indolent Ulcer Chronic Ulcer
Dermatophytosis	Tinea Dermatophytosis, Unspecified Ringworm Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton Cutaneous Mycosis Dermal Mycosis Superficial Mycosis, Unspecified Fungus Infection Of Skin Skin Mycosis Dermatitis Fungoid Fungal Dermatitis Fungal Dermatosis Mycotic Infection Of Skin
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Subacute Leukemia
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS13323	SLC7A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20597	Slc7a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27105	Slc7a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC7A1	VGNC	VGNC:77626
Mus musculus	SLC7A1	MGD	MGI:88117
Bos taurus	SLC7A1	VGNC	VGNC:34924
Canis familiaris	SLC7A1	VGNC	VGNC:46470
Felis catus	SLC7A1	VGNC	VGNC:65421
Rattus norvegicus	SLC7A1	RGD	RGD:3716
Others	SLC7A1	NCBI