GM-60186
Based on 1 Customer Validation
GM-60186 is a 5-HT receptor 2B (HTR2B) inhibitor with an IC50 of 257 nM. GM-60186 significantly inhibits colorectal cancer proliferation and migration.
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- Pureté: 99.34%
- CAS No.: 3097453-30-7
- Formule: C30H33FN2O4
- Masse moléculaire:504.59
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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5-HT2B Receptor 257 nM (IC50) |
GM-60186 (50-500 nM; 72 hours) effectively inhibits the proliferation in colorectal cancer (CRC) cells[1].
GM-60186 (500 nM; 24-48 hours) effectively inhibits colorectal cancer migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:COLO-205, MC38, CT26 and Caco2 cells
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Concentration:0, 50, 100, and 500 nM
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Incubation Time:72 hours
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Result:Demonstrated effective inhibition of cell proliferation in these CRC cell lines.
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Cell Line:COLO-205, CT26 and MC38 cells
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Concentration:500 nM
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Incubation Time:24, and 48 h
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Result:Inhibited colorectal cancer migration.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Homozygous male BALB/c nude mice (CAnN.Cg-Foxn1 nu/Crl; 8-week-old) injected with COLO-205 cells[1]
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Dosage:10 mg/kg; 20 mg/kg
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Administration:IP; daily; for 20 days
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Result:Significantly reduced tumor size and weight.
Chemical Information
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CAS No. 3097453-30-7
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Appearance Solid
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Masse moléculaire 504.59
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Formule C30H33FN2O4
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Color White to off-white
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SMILES
COC1=CC=CC(CCC2=CC=CC=C2OCC(O)CN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (198.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (9.91 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9818 mL | 9.9090 mL | 19.8181 mL | 49.5452 mL |
| 5 mM | 0.3964 mL | 1.9818 mL | 3.9636 mL | 9.9090 mL | |
| 10 mM | 0.1982 mL | 0.9909 mL | 1.9818 mL | 4.9545 mL | |
| 15 mM | 0.1321 mL | 0.6606 mL | 1.3212 mL | 3.3030 mL | |
| 20 mM | 0.0991 mL | 0.4955 mL | 0.9909 mL | 2.4773 mL | |
| 25 mM | 0.0793 mL | 0.3964 mL | 0.7927 mL | 1.9818 mL | |
| 30 mM | 0.0661 mL | 0.3303 mL | 0.6606 mL | 1.6515 mL | |
| 40 mM | 0.0495 mL | 0.2477 mL | 0.4955 mL | 1.2386 mL | |
| 50 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9909 mL | |
| 60 mM | 0.0330 mL | 0.1652 mL | 0.3303 mL | 0.8258 mL | |
| 80 mM | 0.0248 mL | 0.1239 mL | 0.2477 mL | 0.6193 mL | |
| 100 mM | 0.0198 mL | 0.0991 mL | 0.1982 mL | 0.4955 mL |
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