Laricitrin
Based on 1 Customer Validation
Laricitrin is a natural product with multiple biological activities. Laricitrin inhibits the phosphorylation and DNA-binding activity of STAT3, and downregulates the expression of IL-10. Laricitrin acts as an immunomodulator to regulate the differentiation, maturation and function of dendritic cells (DCs). Laricitrin inhibits the migration and invasion of lung cancer cells, and ameliorates lung cancer progression. Laricitrin can be used in research related to hypertension and lung cancer.
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- Pureté : 99.36%
- CAS No.: 53472-37-0
- Formule: C16H12O8
- Masse moléculaire:332.26
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
STAT3 |
IL-10 |
IL-12 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human lung adenocarcinoma H1395 cells, human lung adenocarcinoma HCC2935 cells
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Concentration:2 µM (pretreated on dendritic cells)
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Incubation Time:1 h (dendritic cell pretreatment); 24, 48 h (conditioned media incubation as chemoattractant)
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Result:Inhibited the migration of human lung adenocarcinoma H1395 and HCC2935 cells induced by H1395-TADC-CM, BaP-H1395-TADC-CM, HCC2935-TADC-CM, and BaP-HCC2935-TADC-CM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53472-37-0
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Appearance Solid
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Masse moléculaire 332.26
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Formule C16H12O8
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Color Light yellow to yellow
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SMILES
O=C1C(O)=C(C2=CC(OC)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Pureté et documentation
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Fiche technique (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Chang WA, et al. Laricitrin ameliorates lung cancer-mediated dendritic cell suppression by inhibiting signal transducer and activator of transcription 3. Oncotarget. 2016 Dec 20;7(51):85220-85234. [Content Brief]
[2]. Chang WA, et al. Laricitrin suppresses increased benzo(a)pyrene-induced lung tumor-associated monocyte-derived dendritic cell cancer progression. Oncology letters. 2016 Mar;11(3):1783-1790. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laricitrin Related Classifications
HY-N8840 Related Classifications
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