NT376
NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (HY-149285) (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases.
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- CAS No.: 2820208-97-5
- Formule: C21H20F4N4O2
- Masse moléculaire:436.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
HDAC4 1.26 nM (IC50, HT-29 cells) |
HDAC5 2.85 nM (IC50, HT-29 cells) |
HDAC1 1483 nM (IC50, HT-29 cells) |
HDAC11 4851 nM (IC50, HT-29 cells) |
Class I/IIb >4000 nM (IC50, HT-29 cells) |
HDAC6 5035 nM (IC50, HT-29 cells) |
In Vitro
NT376 (1.26-5035 nM, 3 h) exhibits high selectivity and high potency to class-IIa Histone deacetylases (HDAC)s (IC50=32 nM) over other HDAC classes (IC50= >4.0 µM), performing slightly better than NT160 (HY-149285) in the functional cell-based assay in HT-29 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2820208-97-5
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Masse moléculaire 436.40
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Formule C21H20F4N4O2
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SMILES
O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NT376 Related Classifications
HY-163806 Related Classifications
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