QR-6401
QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer.
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- CAS No.: 2845096-18-4
- Formule: C19H23N5O3
- Masse moléculaire:369.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OVCAR-3 | IC50 |
34 nM
Compound: 23; QR-6401
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Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation incubated for 6 days by CyQUANT reagent assay
Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation incubated for 6 days by CyQUANT reagent assay
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[PMID: 36923916] |
Chemical Information
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CAS No. 2845096-18-4
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Masse moléculaire 369.42
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Formule C19H23N5O3
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SMILES
O=C(N[C@H](C1)C[C@@H]1OC2)O[C@@H](C3)CC[C@@H]3C4=CC(NC5=NC2=CC=C5)=NN4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
QR-6401 Related Classifications
HY-153221 Related Classifications
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