Teixobactin
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III.
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- CAS No.: 1613225-53-8
- Formule: C58H95N15O15
- Masse moléculaire:1242.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Teixobactin (0-128 µg/mL) shows antibacterial activity with a MIC value of 0.25 µg/mL for MRSA ATCC 33591[2].
Teixobactin (0-24 h) shows antibacterial activity with MIC values of 5, 20 ng/mL for Clostridium difficile, Bacillus anthracis, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CD-1 mice (MRSA ATCC33591)[3]
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Dosage:1, 2.5, 5, 10, 20 mg/kg
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Administration:i.v.; once; one hour post-infection
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Result:Showed good antibacterial activity and all treated animals survived.
Chemical Information
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CAS No. 1613225-53-8
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Masse moléculaire 1242.47
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Formule C58H95N15O15
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. [Content Brief]
[2]. Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. [Content Brief]
[3]. Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Teixobactin Related Classifications
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