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Tepoditamab

(Synonyms: MCLA 117)
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Tepoditamab (MCLA-117) is a full-length human IgG1 bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells. Tepoditamab induces upto 30-fold T-cell expansion. Tepoditamab results in moderate to strong cytokine (IFNγ, IL-6, IL-8, IL-10, and TNFα) and IFNγ release in human whole blood and PBMC, respectively. Tepoditamab can be used in acute myeloid leukaemia (AML) research.

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  • Pureté: ≥99%
  • CAS No.: 2044679-53-8
  • Masse moléculaire:144.787 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Experimental Validation Results for Tepoditamab
  • Tepoditamab Chemical Structure
    Tepoditamab Chemical Structure
CAS No.: 2044679-53-8
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Tepoditamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded Tepoditamab on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77633) with an affinity constant of 1.185E-08 M as determined in BLI assay.

  • 1/16

    Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tepoditamab. The EC50 for this effect is 74.47 ng/mL.

  • 1/16

    Immobilized CLEC12A/MICL Protein, Human (HEK293, Fc, HY-P77631) can bind Tepoditamab. The EC50 for this effect is 67.71 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tepoditamab (HY-P99390). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Tepoditamab Chemical Structure
    1/16
  • Tepoditamab
  • Loaded Tepoditamab on AHC2 biosensor, can bind CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi, HY-P77633) with an affinity constant of 1.185E-08 M as determined in BLI assay.
  • Immobilized CD3 epsilon Protein, Human (HEK293, His, HY-P70506) can bind Tepoditamab. The EC50 for this effect is 74.47 ng/mL.
  • Immobilized CLEC12A/MICL Protein, Human (HEK293, Fc, HY-P77631) can bind Tepoditamab. The EC50 for this effect is 67.71 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Tepoditamab (HY-P99390). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.