UNC9750
UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma.
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- CAS No.: 2967648-29-7
- Formule: C23H24N6O
- Masse moléculaire:400.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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DYRK1B |
DAPK1 |
PDGFR |
PDGFR2 |
UNC9750 (Compound 14) (0-10 μM, 48-72 h) decreases human glioblastoma cell U251-MG growth and selectively reduces cellular InsP5 abundance but does not decrease InsP6 or InsP7 levels after 72 h[1].
UNC9750 (1 μM) has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR[1].
UNC9750 (10-50 μM, 24 h) can significantly and concentration-dependently upregulate the expression of SF-1 target gene CYP11A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Cmax | AUClast | Vss | CL |
|---|---|---|---|---|---|---|---|
| Mice[1] | 2.75 mg/kg | i.v. | 1.95 h | 28.3 μM | 4.6 μM·h | 0.39 L/kg | 22.8 mL/min/kg |
Chemical Information
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CAS No. 2967648-29-7
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Masse moléculaire 400.48
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Formule C23H24N6O
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SMILES
C1(C2=NN=NN2)=CC3=C(ON=C3C=C1)C4=CC(C5CCN(CC5)C6CCC6)=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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