YCH3292
YCH3292, a derivative of YCH189 (HY-155993) is a potent, selective and orally active PARP1/2 inhibitor with IC50 both <0.001 nM. YCH3292 can increase the stability of PARP-DNA complexes. YCH3292 exhibits robust antiproliferative activity. YCH3292 can induce double-strand breaks in DNA, increase the protein levels of γH2AX, P-RPA32, and P-Chk1 and induce tumor cells S or G2/M phase arrest and apoptosis. YCH3292 can inhibit tumor growth in MC38 xenograft model.
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- CAS No.: 3049753-10-5
- Formule: C28H23FN6O3
- Masse moléculaire:510.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PARP1 <0.001 nM (IC50) |
PARP2 <0.001 nM (IC50) |
YCH3292 exhibits robust antiproliferative activity against Capan-1/TP cells (IC50 = 0.23 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3049753-10-5
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Masse moléculaire 510.52
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Formule C28H23FN6O3
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SMILES
O=C1NN=C(CC2=CC=C(F)C(C(N3CCN4C(C3)=NN=C4C5=CC=C(C6CC6)O5)=O)=C2)C7=CC=CC=C71
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YCH3292 Related Classifications
HY-180809 Related Classifications
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