Copper sulfate pentahydrate, 99.9%
Based on 1 Customer Validation
Copper sulfate pentahydrate, 99% is a biochemical reagent. Copper sulfate pentahydrate, 99% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, 99% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, 99% is cytotoxic to various cells. Copper sulfate pentahydrate, 99% has antioxidant activity. Copper sulfate pentahydrate, 99% can be used in the research of diabetes, Parkinson's disease and DMBA (HY-W011845)-induced tumors.
For research use only. We do not sell to patients.
- CAS No.: 7758-99-8
- Formula: CuSO4·5H2O
- Molecular Weight:249.69
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Caspase-3 |
Caspase-9 |
Caspase-8 |
Copper sulfate pentahydrate (6.25-200 mg/mL; 24 h), 99.9% significantly decreases the cell viability of three human intestinal epithelial cell lines (HCT116, HT-29 and SW480)[1].
Copper sulfate (2.4 mg Cu/L; 24 h) pentahydrate, 99.9% significantly decreases the viability of primary hepatocytes of Epinephelus coioides[2].
Copper sulfate (5-100 µM) pentahydrate, 99.9% has no effect on CHO cell growth or antibody production, with a slight dose-dependent decrease in culture viability[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:primary hepatocytes of Epinephelus coioides
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Concentration:2.4 mg Cu/L
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Incubation Time:24 h
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Result:Increased the percentages of apoptosis and necrosis.
Increased the activities of caspase-3, caspase-8, and caspase-9.
Copper sulfate (2.5 mg/kg; i.p.; 16/24 h before MPP+) pentahydrate, 99% blocks MPP+-induced striatal lipid peroxidation and dopamine depletion in mice[6].
Copper sulfate (approximately 50 mg Cu2+/liter in drinking water) pentahydrate, 99% delays DMBA (HY-W011845)-induced ovarian granulosa cell tumor development in C57BL/6J female mice[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7758-99-8
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Appearance Solid
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Molecular Weight 249.69
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Formula CuSO4·5H2O
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Color Light blue to blue
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SMILES
O=S([O-])([O-])=O.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Cu+2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : 100 mg/mL (400.50 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (758 KB)
- English - EN (758 KB)
- Français - FR (758 KB)
- Deutsch - DE (758 KB)
- Norwegian - NO (758 KB)
- Español - ES (758 KB)
- Swedish - SV (758 KB)
- Italian - IT (758 KB)
- Korean - KR (758 KB)
- Portuguese - PT (758 KB)
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Handling Instructions (2659 KB)
References
[1]. Feyzi A, et al. Copper sulfate pentahydrate reduced epithelial cytotoxicity induced by lipopolysaccharide from enterogenic bacteria. Biomed Pharmacother. 2017 May;89:454-461. [Content Brief]
[2]. Wang T, et al. Copper Nanoparticles and Copper Sulphate Induced Cytotoxicity in Hepatocyte Primary Cultures of Epinephelus coioides. PLoS One. 2016 Feb 18;11(2):e0149484. [Content Brief]
[3]. Chaderjian WB, et al. Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed. Biotechnol Prog. 2005 Mar-Apr;21(2):550-3. [Content Brief]
[5]. Sitasawad S, et al. Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM). Diabetes Res Clin Pract. 2001 May;52(2):77-84. [Content Brief]
[6]. Alcaraz-Zubeldia M, et al. Neuroprotective effect of acute and chronic administration of copper (II) sulfate against MPP+ neurotoxicity in mice. Neurochem Res. 2001 Jan;26(1):59-64. [Content Brief]
[7]. Burki HR, et al. Effect of oral copper sulfate on 7,12-dimethylbenz(alpha)anthracene carcinogenesis in mice. Br J Cancer. 1969 Sep;23(3):591-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.0050 mL | 20.0248 mL | 40.0497 mL | 100.1242 mL |
| 5 mM | 0.8010 mL | 4.0050 mL | 8.0099 mL | 20.0248 mL | |
| 10 mM | 0.4005 mL | 2.0025 mL | 4.0050 mL | 10.0124 mL | |
| 15 mM | 0.2670 mL | 1.3350 mL | 2.6700 mL | 6.6749 mL | |
| 20 mM | 0.2002 mL | 1.0012 mL | 2.0025 mL | 5.0062 mL | |
| 25 mM | 0.1602 mL | 0.8010 mL | 1.6020 mL | 4.0050 mL | |
| 30 mM | 0.1335 mL | 0.6675 mL | 1.3350 mL | 3.3375 mL | |
| 40 mM | 0.1001 mL | 0.5006 mL | 1.0012 mL | 2.5031 mL | |
| 50 mM | 0.0801 mL | 0.4005 mL | 0.8010 mL | 2.0025 mL | |
| 60 mM | 0.0667 mL | 0.3337 mL | 0.6675 mL | 1.6687 mL | |
| 80 mM | 0.0501 mL | 0.2503 mL | 0.5006 mL | 1.2516 mL | |
| 100 mM | 0.0400 mL | 0.2002 mL | 0.4005 mL | 1.0012 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Copper sulfate pentahydrate, 99.9% Related Classifications
HY-Y1881A Related Classifications
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