Art. -Nr.: HY-15262

SRT 2104

Name: SRT 2104
Brand: MedChemExpress
SKU: HY-15262
Price: 110.00 USD
Availability: InStock
Rating: 5 (25 reviews)

25 Cited Publications

Kundenbewertung

Based on 25 publication(s) in Google Scholar

SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD⁺ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.27%
CAS. Nr.: 1093403-33-8
Formel: C₂₆H₂₄N₆O₂S₂
Molecular Weight:516.64

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

SRT 2104 Chemical Structure

CAS. Nr.: 1093403-33-8

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Publications (25)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll (2)
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

SIRT1

Alle Sirtuin Isoform-spezifische Produkte anzeigen :

In Vivo

SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice^[2].
SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice^[2].
SRT 2104 (0.5% in diet; p.o.; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6 mice (8-week-old)^[2]
Dosage:

100 mg/kg/day
Administration:

Supplemented in diet for 24 weeks
Result:

Enhanced SIRT1 protein without evelating Sirt1 mRNA level. Attenuated diabetes mellitus (DM)-induced oxidative stress, apoptotic signaling, and ER stress.

Animal Model:

WT and N171-82Q HD mice (6 weeks old)^[3]
Dosage:

0.5%
Administration:

0.5% SRT 2104 containing diet for 6, 12, 18 weeks
Result:

Ameliorated motor deficits and increased survival in N171-82Q HD mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 1093403-33-8
Appearance Solid
Molecular Weight 516.64
Formel C₂₆H₂₄N₆O₂S₂
Color Light yellow to yellow
SMILES

O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (25)

All IPCell Proliferation/Viability AssayWBIn Vivo Efficacy StudyRT-PCRIHC

Sort by:

Journal Impact Factor

J Clin Invest

CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties. [Abstract]

2026 Feb 26:e200062. PMID: 41746743
Adv Sci (Weinh)

The Sirt1-Piezo1 Axis Promotes Bone Formation and Repair in Mice. [Abstract]

2025 Sep 26:e10103. PMID: 40999873

SRT 2104 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 26:e10103. [Abstract]

ATDC5 cells were treated with different concentrations of SRT2104 (SRT; 0, 0.5, 1 μM), a specific Sirt1 activator, for 48 h, reduced the acetylation of Piezo1.

SRT 2104 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 26:e10103. [Abstract]

After SRT2104 (SRT; 0, 0.25, 0.5, 1, 2 μM) intervention in ATDC5 cells for 48 h, western blotting was used to detect the expression of Piezo1 protein in the cells.
Neural Regen Res

Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. [Abstract]

2021 Dec;16(12):2465-2474. PMID: 33907035

SRT 2104 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2021 Dec;16(12):2465-2474. [Abstract]

SRT2104 (10 μM) was intracerebroventricularly injected into six diabetic model rats for 16 days, increasing SIRT1, TORC1, p-CREB, and BDNF levels in the hippocampus.

SRT 2104 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2021 Dec;16(12):2465-2474. [Abstract]

SRT2104 (10 μM) was intracerebroventricularly injected into six diabetic model rats for 16 days, significantly increasing the dendritic lengths and spine densities in the hippocampus of diabetic model rats.
Mol Cancer Ther

2026 Jul 15:10.1158/1535-7163.MCT-26-0182. PMID: 42456172
Ecotoxicol Environ Saf

Acetylation of FOXO1 is involved in cadmium-induced rat kidney injury via mediating autophagosome-lysosome fusion blockade and autophagy inhibition. [Abstract]

2024 Nov 15:287:117253. PMID: 39536554
Biochem Pharmacol

Dapagliflozin ameliorates diabetic kidney disease by inhibiting oxidative stress and AIM2-dependent pyroptosis via SIRT1 activation. [Abstract]

2026 Jun 25;251(Pt 2):118200. PMID: 42349619
Pak Vet J

2026 Feb 14.46(2):460-467.
J Endocrinol

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53. [Abstract]

2018 Apr;237(1):1-14. PMID: 29371235
Int J Mol Sci

The Impact of SRT2104 on Skeletal Muscle Mitochondrial Function, Redox Biology, and Loss of Muscle Mass in Hindlimb Unloaded Rats. [Abstract]

2023 Jul 6;24(13):11135. PMID: 37446313
Int J Mol Sci

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer's Disease. [Abstract]

2023 Apr 9;24(8):6968. PMID: 37108131
Biomolecules

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia. [Abstract]

2022 Mar 9;12(3):422. PMID: 35327614
J Mol Med (Berl)

MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death. [Abstract]

2018 Sep;96(9):939-949. PMID: 30030567

SRT 2104 purchased from MedChemExpress. Usage Cited in: J Mol Med (Berl). 2018 Sep;96(9):939-949. [Abstract]

To test the effect of miR-34a inhibition and SIRT1 activation on the expression of miR-34a and Sirt1, the diabetic mice are treated with NC-I, miR-34a-I or SRT2104. Sirt1 mRNA levels are determined by qPCR.
Sci Rep

SIRT1 induces FOXO1/autophagy/NCOA4-induced ferroptosis and accelerates the progression of cerebral infarction by inhibiting the E2F1/NOTCH-1/YAP signaling pathway. [Abstract]

2026 Mar 17;16(1):13946. PMID: 41844756
Sci Rep

Luteoloside alleviates bleomycin-induced pulmonary fibrosis in mice via SIRT1-mediated protective effect against alveolar epithelial cell senescence. [Abstract]

2025 Oct 29;15(1):37837. PMID: 41162593
Brain Res Bull

Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage. [Abstract]

2023 Oct 15:203:110780. PMID: 37820952
Biochim Biophys Acta Mol Cell Res

P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy. [Abstract]

2019 Aug;1866(8):1272-1281. PMID: 30959066
J Funct Foods

2024 Dec.
COPD

Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. [Abstract]

2020 Aug;17(4):444-451. PMID: 32722945
Cartilage

Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1. [Abstract]

2021 Dec;13(2_suppl):1356S-1366S. PMID: 31989845

SRT 2104 purchased from MedChemExpress. Usage Cited in: Cartilage. 2021 Dec;13(2_suppl):1356S-1366S. [Abstract]

Safranin O-fast green staining of the medial knee joint at 4, 8, 12, and 16 weeks postsurgery. Scale bar = 100 μm.
J Food Biochem

2026 May 25;2026(1):3782560.
Neurosci Lett

Ameliorative effect of SIRT1 in postpartum depression mediated by upregulation of the glucocorticoid receptor. [Abstract]

2021 Sep 14:761:136112. PMID: 34265417
Biomed Pharmacother

Vitamin D and SIRT1 activator SRT2104 cooperate in antiproliferative activity in lung cancer through ferroptosis induction. [Abstract]

2025 Sep:190:118391. PMID: 40768932

SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391. [Abstract]

Cells were treated with SRT2104 at the concentration of 5 and 12.5 µM for 96 h.

SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391. [Abstract]

Lung cancer cell lines were treated with calcitriol (10 nM for EGFR mutant cells and HSAEC or 100 nM for other cell lines) and SRT2104 (5 µM) for 72 h. Representative blots of VDR, CYP24 A1 and SIRT1.

SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391. [Abstract]

Lung cancer cell lines were treated with calcitriol (10 nM for EGFR mutant cells and HSAEC or 100 nM for other cell lines) and SRT2104 (5 µM) for 72 h. Relative CYP24 A1 mRNA expression determined by RT-qPCR.
Res Sq

2025 May 15.
bioRxiv

Metabolic reprogramming in the spinal cord drives the transition to pain chronicity. [Abstract]

2025 Feb 1:2025.01.30.635746. PMID: 39975205
Patent

US20180263995A1.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 5 mg/mL (9.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9356 mL

9.6779 mL

19.3558 mL

5 mM

0.3871 mL

1.9356 mL

3.8712 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

All Molecular Biology Signal Pathway Related

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hoffmann E, et al. Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man. [Content Brief]

[2]. Jiao D, et al. MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death. J Mol Med (Berl). 2018 Sep;96(9):939-949. [Content Brief]

[3]. Jiang M, et al. Sirtuin 1 activator SRT2104 protects Huntington's disease mice. Ann Clin Transl Neurol. 2014 Dec;1(12):1047-52. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9356 mL	9.6779 mL	19.3558 mL	48.3896 mL
DMSO	5 mM	0.3871 mL	1.9356 mL	3.8712 mL	9.6779 mL

Bioz

Keywords

SRT 2104

25 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

SRT 2104

Publications Citing Use of MedChemExpress (MCE) SRT 2104

Alle Sirtuin Isoform-spezifische Produkte anzeigen