HDAC6-IN-43
HDAC6-IN-43 (compound 26) is a potent HDAC inhibitor. HDAC6-IN-43 effectively inhibits several HDACs, notably HDAC1, HDAC2, and HDAC6 (IC50 < 150 nM), displaying a particularly high sensitivity towards HDAC6 (IC50 = 11 nM). HDAC6-IN-43 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3037978-19-8
- Formel: C21H24N2O4S
- Molecular Weight:400.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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HDAC6 11 ± 1 nM (IC50) |
HDAC2 105 ± 5 nM (IC50) |
HDAC1 111 ± 5 nM (IC50) |
HDAC8 15404 ± 99 nM (IC50) |
HDAC6-IN-43 (compound 26) significantly inhibits Madin-Darby canine kidney (MDCK) cell growth and proliferation by upregulating the acetylation of α-tubulin levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3037978-19-8
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Molecular Weight 400.49
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Formel C21H24N2O4S
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SMILES
COC1=C(OCCCCCCC(NO)=O)C=C(C2=NC3=CC=CC=C3S2)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC6-IN-43 Related Classifications
HY-161524 Related Classifications
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