Orazipone
Orazipone (OR 1384) is a small molecule immunomodulator with strong anti-inflammatory properties. Orazipone exerts its immunomodulatory effect by forming reversible thiol complexes, which bind to intracellular signaling proteins and the thiol groups of glutathione. Orazipone exhibits potent anti-eosinophilic activity by inducing apoptosis. Orazipone inhibits activation of inflammatory transcription factors NF-kB and STAT 1 and decreases inducible iNOS expression and NO production in response to inflammatory stimuli. Orazipone reduces NADPH oxidase activity and thereby decreases ROS production. Orazipone has a protective effect in intestinal radiation injury.
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- CAS. Nr.: 137109-78-5
- Formel: C13H14O4S
- Molecular Weight:266.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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NF-κB |
STAT1 |
iNOS |
Chemical Information
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CAS. Nr. 137109-78-5
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Molecular Weight 266.31
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Formel C13H14O4S
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SMILES
O=C(C)/C(C(C)=O)=C\C1=CC=C(S(=O)(C)=O)C=C1
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Synonyms
OR 1384
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sareila O, et al. Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli. J Pharmacol Exp Ther. 2008 Feb;324(2):858-66. [Content Brief]
[2]. Boerma M, et al. Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model. Int J Radiat Oncol Biol Phys. 2006 Oct 1;66(2):552-9. [Content Brief]
[3]. Kankaanranta H, et al. Antieosinophilic activity of orazipone. Mol Pharmacol. 2006 Jun;69(6):1861-70. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Orazipone Related Classifications
HY-106981 Related Classifications
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