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Art. -Nr.: HY-182448

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TDI-11904

TDI-11904 is a peripherally active EZH2 inhibitor with an EZH2 IC₅₀ of 0.9 nM. TDI-11904 inhibits EZH2 methyltransferase activity, reduces the trimethylation level of H3K27me3, and decreases intracellular H3K27me3 content. TDI-11904 inhibits the proliferation of lymphoma cells. TDI-11904 can be used for the research of lymphoma.

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CAS. Nr.: 3056015-44-9
Formel: C₂₃H₂₄Cl₂N₄O₃S
Molecular Weight:507.43

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Please store the product under the recommended conditions in the Certificate of Analysis.

TDI-11904 Chemical Structure

CAS. Nr.: 3056015-44-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biologische Aktivität

Beschreibung

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	IC₅₀	125 nM Compound: 21	Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 72 hrs followed by compound dilution in growth medium and measured after 96 hrs by Alamar blue assay Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 72 hrs followed by compound dilution in growth medium and measured after 96 hrs by Alamar blue assay	[PMID: 35300079]

In Vitro

TDI-11904 inhibits H3K27me3 in Karpas-422 cells with an IC₅₀ of 6.0 nM^[1].
TDI-11904 inhibits Karpas-422 cell proliferation with an IC₅₀ of 125 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3056015-44-9
Molecular Weight 507.43
Formel C₂₃H₂₄Cl₂N₄O₃S
SMILES

O=C1NC(C)=CC(SC)=C1CN2C(C3=C(C(C4=C(C)ON=C4C)=CC(Cl)=C3N(CC2)C)Cl)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Liang R, et al. A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors. ACS Med Chem Lett. 2022;13(3):377-387. Published 2022 Feb 10. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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TDI-11904

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

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TDI-11904 Related Classifications

HY-182448 Related Classifications