Cinoxacin
Based on 1 publication(s) in Google Scholar
Cinoxacin (Compound 64716), a synthetic antimicrobial related to the quinolone class of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibits bacterial DNA synthesis. Cinoxacin can be used for the research of urinary tract infections and bacterial prostatitis.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 28657-80-9
- Formula: C12H10N2O5
- Molecular Weight:262.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Cinoxacin
MoreAll Antibiotic Isoforms
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
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Quinolone |
Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Gram-negative aerobic bacteria (Escherichia coli, Proteus sp. etc.)
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Concentration:0-200μg/mL approximately
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Incubation Time:3-24 h
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Result:Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Indicated bacterial infected mice model[2]
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Dosage:1.7 g/kg, treated at 1 and 5 h postinfection
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Administration:Oral administration
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Result:Displayed antibacterial activity with ED50 values ranging from 8.1 to 58.6 mg/kg.
Chemical Information
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CAS No. 28657-80-9
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Appearance Solid
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Molecular Weight 262.22
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Formula C12H10N2O5
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Color White to off-white
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SMILES
O=C(C1=NN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O
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Synonyms
Compound 64716
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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J Chem Inf Model
Development of Machine Learning Models and the Discovery of a New Antiviral Compound against Yellow Fever Virus. [Abstract]2021 Aug 23;61(8):3804-3813. PMID: 34286575
Solvent & Solubility
DMSO : 8.33 mg/mL (31.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Scavone JM, et al. Cinoxacin: mechanism of action, spectrum of activity, pharmacokinetics, adverse reactions, and therapeutic indications. Pharmacotherapy. 1982 Sep-Oct;2(5):266-72. [Content Brief]
[2]. W E Wick, et al. Compound 64716, a new synthetic antibacterial agent. Antimicrob Agents Chemother. 1973 Oct;4(4):415-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8136 mL | 19.0680 mL | 38.1359 mL | 95.3398 mL |
| 5 mM | 0.7627 mL | 3.8136 mL | 7.6272 mL | 19.0680 mL | |
| 10 mM | 0.3814 mL | 1.9068 mL | 3.8136 mL | 9.5340 mL | |
| 15 mM | 0.2542 mL | 1.2712 mL | 2.5424 mL | 6.3560 mL | |
| 20 mM | 0.1907 mL | 0.9534 mL | 1.9068 mL | 4.7670 mL | |
| 25 mM | 0.1525 mL | 0.7627 mL | 1.5254 mL | 3.8136 mL | |
| 30 mM | 0.1271 mL | 0.6356 mL | 1.2712 mL | 3.1780 mL |
Cinoxacin Related Classifications
HY-B1085 Related Classifications
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