Polymyxin B2
Based on 1 Customer Validation
Polymyxin B2 is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 is used in studies related to Pseudomonas aeruginosa infection and acute enteritis.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 34503-87-2
- Formula: C55H96N16O13
- Molecular Weight:1189.45
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Antibiotic Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
159 μg/mL
Compound: Polymyxin B2
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Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
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[PMID: 29412662] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 34503-87-2
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Appearance Solid
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Molecular Weight 1189.45
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Formula C55H96N16O13
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (84.07 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Han W, et al. New antimicrobial peptide-antibiotic combination strategy for Pseudomonas aeruginosa inactivation. Biointerphases. 2022;17(4):041002. Published 2022 Aug 3. [Content Brief]
[2].
Zheng L, et al. Lactiplantibacillus plantarum and Saccharomyces cerevisiae-Fermented Coconut Water Alleviates Dextran Sodium Sulfate-Induced Enteritis in Wenchang Chicken: A Gut Microbiota and Metabolomic Approach. Animals (Basel). 2024 Feb 8;14(4):575.
[Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8407 mL | 4.2036 mL | 8.4072 mL | 21.0181 mL |
| 5 mM | 0.1681 mL | 0.8407 mL | 1.6814 mL | 4.2036 mL | |
| 10 mM | 0.0841 mL | 0.4204 mL | 0.8407 mL | 2.1018 mL | |
| 15 mM | 0.0560 mL | 0.2802 mL | 0.5605 mL | 1.4012 mL | |
| 20 mM | 0.0420 mL | 0.2102 mL | 0.4204 mL | 1.0509 mL | |
| 25 mM | 0.0336 mL | 0.1681 mL | 0.3363 mL | 0.8407 mL | |
| 30 mM | 0.0280 mL | 0.1401 mL | 0.2802 mL | 0.7006 mL | |
| 40 mM | 0.0210 mL | 0.1051 mL | 0.2102 mL | 0.5255 mL | |
| 50 mM | 0.0168 mL | 0.0841 mL | 0.1681 mL | 0.4204 mL | |
| 60 mM | 0.0140 mL | 0.0701 mL | 0.1401 mL | 0.3503 mL | |
| 80 mM | 0.0105 mL | 0.0525 mL | 0.1051 mL | 0.2627 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Polymyxin B2 Related Classifications
HY-A0248B Related Classifications
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- Polymyxin B2
- 34503-87-2
- Polymyxin B 2
- Polymyxin B-2
- Antibiotic
- Bacterial
- Saccharomyces cerevisiae Y301
- Wenchang chicks
- Alistipes
- Pseudomonas aeruginosa PA103
- dextran sulfate sodium
- Pseudomonas aeruginosa
- acute enteritis
- Lactiplantibacillus plantarum MS2c
- LL37
- pseudomonas aeruginosa infections
- Inhibitor
- inhibitor
- inhibit