Dehydroherbarin
Dehydroherbarin is a selective inhibitor targeting HSP90α with blood-brain barrier penetration. Dehydroherbarin interferes with key pathways of tumor cell survival by binding to HSP90α, while exerting moderate antibacterial and anti-hepatitis A virus activities and inhibiting tumor cell migration. Dehydroherbarin can be used in research on tumors such as breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 36379-74-5
- Formula: C16H14O5
- Molecular Weight:286.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
HSP90 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| PC-3M | IC50 |
3.5 μM
Compound: 5
|
Antiproliferative activity against human PC3M cells after 40 hrs by MTT assay
Antiproliferative activity against human PC3M cells after 40 hrs by MTT assay
|
[PMID: 17988097] |
Chemical Information
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CAS No. 36379-74-5
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Molecular Weight 286.28
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Formula C16H14O5
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SMILES
O=C1C2=C(C(C3=C1C=C(C)OC3)=O)C(OC)=CC(OC)=C2
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Structure Classification
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Initial Source
endophytic Chaetosphaeronema sp. (KY321184)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)