Dihydroartemisinin-d3
Dihydroartemisinin-d3 (Dihydroqinghaosu-d3; β-Dihydroartemisinin-d3; Artenimol-d3) is the deuterated-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin (Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol) is an orally active metabolite of Artemisinin (HY-B0094) and an antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin inhibits CYP1A2 and CYP2C19. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin has schistosomicidal activity against schistosomula and adult worms of Schistosoma japonicum, reduces worm burden, and exhibits Antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.
For research use only. We do not sell to patients.
- CAS No.: 176774-98-4
- Formula: C15H21D3O5
- Molecular Weight:287.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
Description
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Schistosome |
CYP1A2 |
CYP2C19 |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 176774-98-4
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Unlabeled CAS 71939-50-9
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Molecular Weight 287.37
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Formula C15H21D3O5
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SMILES
C[C@@](OO1)(CC[C@@]2([H])[C@@H](CC3)C)O[C@](O[C@@H]4O)([H])[C@@]12[C@]3([H])[C@H]4C([2H])([2H])[2H]
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Synonyms
Dihydroqinghaosu-d3; β-Dihydroartemisinin-d3; Artenimol-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hu W, et al. Dihydroartemisinin induces autophagy by suppressing NF-κB activation. Cancer Lett. 2014;343(2):239-248. [Content Brief]
[2]. Li YJ, et al. Dihydroartemisinin accentuates the anti-tumor effects of photodynamic therapy via inactivation of NF-κB in Eca109 and Ec9706 esophageal cancer cells. Cell Physiol Biochem. 2014;33(5):1527-1536. [Content Brief]
[3]. Li HJ, et al. Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice. Ann Trop Med Parasitol. 2011 Jun;105(4):329-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydroartemisinin-d3 Related Classifications
HY-N0176S Related Classifications
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Keywords
- Dihydroartemisinin-d3
- 176774-98-4
- Dihydroqinghaosu-d3
- β-Dihydroartemisinin-d3
- Artenimol-d3
- Isotope-Labeled Compounds
- Parasite
- NF-κB
- Cytochrome P450
- Autophagy
- Reactive Oxygen Species (ROS)
- Drug Metabolite
- Nuclear factor-κB
- Nuclear factor-kappaB
- CYPs
- RelA/p65
- NB4 cells
- HCT116 cells
- RPMI 8226 cells
- esophageal cancer cells
- autophagy
- IκBα
- Schistosoma japonicum
- HeLa cells
- Inhibitor
- inhibitor
- inhibit