SF2312
Based on 1 Customer Validation
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 107729-45-3
- Formula: C4H8NO6P
- Molecular Weight:197.08
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SF2312 is selectively toxic to ENO1-deleted glioma cells. SF2312 inhibits the proliferation (2 weeks treatment course) of the ENO1-deleted D423 glioma cell line in the low μM range whist isogenically ENO1-rescued D423 cells, ectopically re-expressing ENO1 only shows inhibition of proliferation at concentrations of SF2312 above 200 μM. SF2312 (10 μM) dose-dependently reduces the conversion of U-13C glucose to 13C lactate in a manner selective for ENO1-deleted over ENO1-rescued or otherwise ENO1-intact glioma cells[1].
SF2312 is produced by the actinomycete Micromonospora and is active against a range of bacteria, with strong activity against Salmonella and Staphylococcus, weak activity against E. coli, and no activity against fungi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 107729-45-3
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Appearance Oil
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Molecular Weight 197.08
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Formula C4H8NO6P
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Color Light yellow to yellow
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SMILES
O=C1N(C(CC1P(O)(O)=O)O)O
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Structure Classification
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Initial Source
Micromonospora sp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 125 mg/mL (634.26 mM; Need ultrasonic)
DMSO : 10 mg/mL (50.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (614 KB)
- English - EN (614 KB)
- Français - FR (614 KB)
- Deutsch - DE (614 KB)
- Norwegian - NO (614 KB)
- Español - ES (614 KB)
- Swedish - SV (614 KB)
- Italian - IT (614 KB)
- Korean - KR (614 KB)
- Portuguese - PT (614 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.0741 mL | 25.3704 mL | 50.7408 mL | 126.8520 mL |
| 5 mM | 1.0148 mL | 5.0741 mL | 10.1482 mL | 25.3704 mL | |
| 10 mM | 0.5074 mL | 2.5370 mL | 5.0741 mL | 12.6852 mL | |
| 15 mM | 0.3383 mL | 1.6914 mL | 3.3827 mL | 8.4568 mL | |
| 20 mM | 0.2537 mL | 1.2685 mL | 2.5370 mL | 6.3426 mL | |
| 25 mM | 0.2030 mL | 1.0148 mL | 2.0296 mL | 5.0741 mL | |
| 30 mM | 0.1691 mL | 0.8457 mL | 1.6914 mL | 4.2284 mL | |
| 40 mM | 0.1269 mL | 0.6343 mL | 1.2685 mL | 3.1713 mL | |
| 50 mM | 0.1015 mL | 0.5074 mL | 1.0148 mL | 2.5370 mL | |
| H2O | 60 mM | 0.0846 mL | 0.4228 mL | 0.8457 mL | 2.1142 mL |
| 80 mM | 0.0634 mL | 0.3171 mL | 0.6343 mL | 1.5857 mL | |
| 100 mM | 0.0507 mL | 0.2537 mL | 0.5074 mL | 1.2685 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
SF2312 Related Classifications
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