LY2457546
LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 908265-94-1
- Fòrmula: C28H20F4N4O
- Peso molecular:504.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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VEGFR2 |
PDGFRβ |
Tie2 |
Chemical Information
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No. CAS 908265-94-1
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Peso molecular 504.48
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Fòrmula C28H20F4N4O
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SMILES
O=C(CC1=CC=C(C2=CN=C3C=C(C4=CC(C)=NC=C4)C=CN32)C=C1F)NC5=CC=CC(C(F)(F)F)=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Burkholder TP, et al. Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model. Invest New Drugs. 2012 Jun;30(3):936-49. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY2457546 Related Classifications
HY-107144 Related Classifications
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