Fasudil hydrochloride solution
Fasudil hydrochloride solution is mainly composed of Fasudil hydrochloride (HY-10341). Fasudil (HA-1077; AT877) hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride is also a potent Ca2+ channel antagonist and vasodilator,and can improve and prevent cerebral vasospasm after subarachnoid hemorrhage surgery and the resulting cerebral ischemic symptoms.
For research use only. We do not sell to patients.
- CAS No.: 105628-07-7
- Formula: C14H18ClN3O2S
- Molecular Weight:327.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Calcium Channel Isoforms
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Biological Activity
Description
Chemical Information
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CAS No. 105628-07-7
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Molecular Weight 327.83
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Formula C14H18ClN3O2S
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SMILES
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl[H]
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Synonyms
HA-1077 hydrochloride solution; AT-877 hydrochloride solution
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen M, et al. Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? Expert Opin Investig Drugs. 2013 Apr;22(4):537-50. [Content Brief]
[2]. Huang XN, et al. The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cordbarrier following experimental autoimmune encephalomyelitis. J Neuroimmunol. 2011 Oct 28;239(1-2):61-7. [Content Brief]
[3]. Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4. [Content Brief]
[4]. Fukushima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38. [Content Brief]
[5]. Corbin KD, et al. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol. 2012 Mar;28(2):159-65. [Content Brief]
[6]. Zhang J, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80. [Content Brief]
[7]. Sun X, et al. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Nov;180(1-2):126-34. Epub 2006 Sep 22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Fasudil hydrochloride solution
- 105628-07-7
- HA-1077 hydrochloride solution
- AT-877 hydrochloride solution
- Calcium Channel
- PKA
- ROCK
- HIV
- Autophagy
- PKC
- orally active
- protein kinases
- collagen
- a-SMA
- TIMP-1
- ERK1/2
- JNK
- p38
- rat HSCs
- human HSC
- TWNT-4 cells
- Ca2+ channel antagonist
- vasodilator
- lysophoaphatidic acid
- LPA
- Inhibitor
- inhibitor
- inhibit