Cat. No.: HY-N7112

Leucomycin

(Synonyms: Kitasamycin)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Leucomycin (Kitasamycin) is an orally active macrolide antibiotic produced by Streptomyces kitasatoensis. Leucomycin has broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, mycoplasma, leptospira, spirochaetes, rickettsiae and some larger viruses.

For research use only. We do not sell to patients.

CAS No.: 1392-21-8

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Leucomycin Chemical Structure

CAS No.: 1392-21-8

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Macrolide

All Antibiotic Isoforms :

In Vitro

Leucomycin (0.1-100 μg/mL, 0-8 h) demonstrates weak bactericidal activities against Staphylococci similar to Maridomycin in vitro^[6].

Antibacterial spectra of Leucomycin^[6]

Organism	Staphylococcus aureus FDA209 P	Streptococcuspyogenes E-14	Streptococcus viridans	Diplococcus pneumoniae type I	Corynebacterium diphtheriae	Bacillus subtilis	Neisseria gonorrhoeae
MIC in μg/mL	1.56	0.78	0.39	0.39	0.39	1.56	0.78

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Leucomycin ( 29.8-446 mg/kg, s.c., i.p., i.v., p.o., a single dose for 7 days) has therapeutic activities on S. aureus 308 A-1, S. pyogenes E-14 and D. pneumoniae type I infection in mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice infected by S. aureus 308 A-1, S. pyogenes E-14 and D. pneumoniae type I^[6]
Dosage:

29.8-446 mg/kg
Administration:

s.c., i.p., i.v., p.o., a single dose for 7 days
Result:

Was relatively high in the therapeutic activity of staphylococcal or streptococcal infection compared to maridomycin in oral route.
Was approximately equal in the therapeutic activity of diplococcal infection compared to maridomycin in oral route.
Showed the same therapeutic activity as Maridomycin against Gram-positive bacterial infections in subcutaneous, intraperitoneal and intravenous administration.

Chemical Information

CAS No. 1392-21-8
Appearance Solid
Color White to off-white
SMILES

[Leucomycin]
Synonyms

Kitasamycin
Structure Classification
- Antibiotics
- Macrolide Antibiotics
Initial Source
- Microorganisms
Streptomyces kitasatoensis
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Autophagy

Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis. [Abstract]

2026 Feb 15:1-19. PMID: 41612599

Solvent & Solubility

In Vitro:

DMSO : 110 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.75 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.75 mg/mL; Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.75 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.75 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 2.75 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (27.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. PACHTMAN EA, et al. Leucomycin; a new antibiotic. Am J Pharm Sci Support Public Health. 1958 Oct;130(10):342-4. [Content Brief]

[2]. Vézina C, et al. Biosynthesis of kitasamycin (leucomycin) by leucine analog-resistant mutants of Streptomyces kitasatoensis. Antimicrob Agents Chemother. 1979 May;15(5):738-46. [Content Brief]

[3]. La T, et al. Testing the efficacy of kitasamycin for use in the control and treatment of swine dysentery in experimentally infected pigs. Aust Vet J. 2019 Sep 17. [Content Brief]

[4]. Hassan AB, et al. Pharmacokinetics and tissue residues of kitasamycin in healthy and diseased broilers. Dtsch Tierarztl Wochenschr. 1990 Aug;97(8):315-7. [Content Brief]

[5]. Iwata K, et al. Studies on the in vitro Antibacterial Activity of Leucomycin[J]. The Journal of Antibiotics, Series A, 1962, 15(6): 258-265.

[6]. Kondo M, et al. Maridomycin, a new macrolide antibiotic. 3. In vitro and in vivo antibacterial activity. J Antibiot (Tokyo). 1973 Apr;26(4):206-14. [Content Brief]

[7]. Liu G, et al. Quantitative analysis of impurities in leucomycin bulk drugs and tablets: A high performance liquid chromatography-charged aerosol detection method and its conversion to ultraviolet detection method. J Pharm Biomed Anal. 2021 Aug 5;202:114148. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Leucomycin

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Publications Citing Use of MedChemExpress (MCE) Leucomycin

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Calculators

Help & FAQs

Leucomycin

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Infection Compound Library

Natural Product Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Macrocyclic Compound Library

Antibacterial Compound Library

NMPA-Approved Drug Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Antibiotics Library

Microbial Metabolite Library

Human Metabolite Library

Off-patent Drug Library

Bioactive Compound Library Max

Natural Product and Natural Product-Like Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Publications Citing Use of MedChemExpress (MCE) Leucomycin

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Calculators

Help & FAQs

Leucomycin Related Classifications

HY-N7112 Related Classifications