MSOP
Based on 1 Customer Validation
MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.0%
- No. CAS: 66515-29-5
- Fòrmula: C4H10NO6P
- Peso molecular:199.10
-
Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-15129
O-Phospho-L-serineEndogenous Metabolite -
HY-100403
Ro 67-7476mGluR1 PAM -
HY-13058
ADX-47273mGluR5 PAM -
HY-101226R
MSOP (Standard)mGLuR Antagonist -
HY-100407
JNJ16259685mGlu1 Receptor Antagonist -
HY-100409
PHCCCGroup I mGluR Antagonist -
HY-14419
TCN238mGlu4 Receptor PAM -
HY-W014666
Xanthurenic acid -
HY-100588
VU0364770mGlu4 PAM -
HY-18941
EglumegadmGlu2/3 Receptor Agonist -
HY-101364
CHPGmGluR5 Agonist -
HY-100781A
L-AP4Group III mGluRs Agonist
Actividad biológica
Descripciòn
IC50 & Target
KD: 51 μM (L-AP4-sensitive presynaptic mGluR)[1].
In Vitro
In the presence of 200 μM MSOP, a rightward parallel shift of the dose-response curve to L-AP4 is observed, with an apparent KD calculated as 51±6 μM (n=3). MSOP is shown to be selective for the L-APC sensitive presynaptic mGluR, the apparent KD for the interaction of MSOP with the (1S, 3S)-ACPD sensitive receptor calculated as greater than 700 μM (n=3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 66515-29-5
-
Appearance Solid
-
Peso molecular 199.10
-
Fòrmula C4H10NO6P
-
Color White to off-white
-
SMILES
NC(COP(O)(O)=O)(C)C(O)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
In Vitro:
H2O : 62.5 mg/mL (313.91 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (275 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Thomas NK, et al. alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology. 1996 Jun;35(6):637-42. [Content Brief]
[2]. Myron Yaster, et al. Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund’s adjuvant. Anesthesiology. 2011 Feb; 114(2): 412–423. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0226 mL | 25.1130 mL | 50.2260 mL | 125.5650 mL |
| 5 mM | 1.0045 mL | 5.0226 mL | 10.0452 mL | 25.1130 mL | |
| 10 mM | 0.5023 mL | 2.5113 mL | 5.0226 mL | 12.5565 mL | |
| 15 mM | 0.3348 mL | 1.6742 mL | 3.3484 mL | 8.3710 mL | |
| 20 mM | 0.2511 mL | 1.2557 mL | 2.5113 mL | 6.2783 mL | |
| 25 mM | 0.2009 mL | 1.0045 mL | 2.0090 mL | 5.0226 mL | |
| 30 mM | 0.1674 mL | 0.8371 mL | 1.6742 mL | 4.1855 mL | |
| 40 mM | 0.1256 mL | 0.6278 mL | 1.2557 mL | 3.1391 mL | |
| 50 mM | 0.1005 mL | 0.5023 mL | 1.0045 mL | 2.5113 mL | |
| 60 mM | 0.0837 mL | 0.4186 mL | 0.8371 mL | 2.0928 mL | |
| 80 mM | 0.0628 mL | 0.3139 mL | 0.6278 mL | 1.5696 mL | |
| 100 mM | 0.0502 mL | 0.2511 mL | 0.5023 mL | 1.2557 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MSOP Related Classifications
HY-101226 Related Classifications
Powered by Bioz