BY27
BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity.
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- No. CAS: 2247236-59-3
- Fòrmula: C22H21ClN6
- Peso molecular:404.90
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
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BRD2 BD2 3.1 nM (Ki) |
BRD2 BD1 95.5 nM (Ki) |
BRD3 BD2 5.3 nM (Ki) |
BRD3 BD1 77.9 nM (Ki) |
BRD4 BD2 7.3 nM (Ki) |
BRD4 BD1 80 nM (Ki) |
BRD2 BD2 1.2 nM (Kd) |
BRD2 BD1 45 nM (Kd) |
BRD3 BD2 2.6 nM (Kd) |
BRD3 BD1 12 nM (Kd) |
BRD4 BD2 3.5 nM (Kd) |
BRD4 BD1 26 nM (Kd) |
BRDT BD2 3 nM (Kd) |
BRDT BD1 64 nM (Kd) |
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Cell Line
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Type | Value | Description | References |
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| MM1.S | IC50 |
16.7 nM
Compound: 47; BY27
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Antiproliferative activity against human MM1S cells assessed as cell growth inhibition after 4 days by CCK8 assay
Antiproliferative activity against human MM1S cells assessed as cell growth inhibition after 4 days by CCK8 assay
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[PMID: 31461688] |
| MM1.S | IC50 |
2324 nM
Compound: 14; BY27
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Antiproliferative activity against human MM1.S cells assessed as cell growth inhibition measured after 4 days by CellTitre-Glo assay
Antiproliferative activity against human MM1.S cells assessed as cell growth inhibition measured after 4 days by CellTitre-Glo assay
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[PMID: 37084596] |
| MV4-11 | IC50 |
27 nM
Compound: 47; BY27
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Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition after 4 days by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition after 4 days by CCK8 assay
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[PMID: 31461688] |
| MV4-11 | IC50 |
270 nM
Compound: 14; BY27
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Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition measured after 3 days by CellTitre-Glo assay
Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition measured after 3 days by CellTitre-Glo assay
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[PMID: 37084596] |
Chemical Information
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No. CAS 2247236-59-3
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Peso molecular 404.90
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Fòrmula C22H21ClN6
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SMILES
CN1N=CC(C2=CC=C(N3C(CC[C@H]4NC5=CC=C(Cl)C=C5)=NN=C3C)C4=C2)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BY27 Related Classifications
HY-126325 Related Classifications
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