Celastramycin A
Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml. Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 188988-62-7
- Fòrmula: C17H18Cl3NO3
- Peso molecular:390.69
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Antibiotic
More
Actividad biológica
Chemical Information
-
No. CAS 188988-62-7
-
Peso molecular 390.69
-
Fòrmula C17H18Cl3NO3
-
SMILES
O=C(C1=C(O)C(CCCCCC)=CC(Cl)=C1O)C2=CC(Cl)=C(Cl)N2
-
Structure Classification
-
Initial Source
Drosophila
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Pullen C, et al., New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta. 2002 Nov;216(1):162-7. [Content Brief]
[2]. Kikuchi H, et al., Revised structure and synthesis of celastramycin a, a potent innate immune suppressor. Org Lett. 2009 Apr 16;11(8):1693-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Celastramycin A Related Classifications
HY-122292 Related Classifications
Powered by Bioz