cis-ACPD
cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 477331-06-9
- Fòrmula: C7H11NO4
- Peso molecular:173.17
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-B1776A
Spermidine hydrochlorideAntioxidant Agent -
HY-100834
5,7-Dichlorokynurenic acidNMDA Receptor Antagonist -
HY-13457
TCN 201NMDA Receptor Antagonist -
HY-100797
(RS)-CPPNMDA Antagonist -
HY-B1776AR
Spermidine hydrochloride (Standard)Antioxidant Agent -
HY-15084A
(-)-Dizocilpine maleateNMDA Receptor Antagonist -
HY-100814
(R)-CPPNMDA Receptor Inhibitor -
HY-107711
DQP-1105GluN1/GluN2C Antagonist -
HY-30006
1-Aminocyclobutanecarboxylic acidCyclobutane-type Amino Acid -
HY-15086
SelfotelNMDA Antagonist -
HY-100920
Arcaine sulfateNMDA Receptor Antagonist -
HY-101178
L-689560NMDA Antagonist
Ver todos los productos específicos de isoformas iGluR
More
Actividad biológica
Descripciòn
|
NMDA Receptor 3.3 μM (IC50) |
mGluR2 13 μM (EC50) |
mGluR4 50 μM (EC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>100 μM
Compound: 17
|
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
|
[PMID: 15801843] |
| HEK293 | EC50 |
48 μM
Compound: 2 ; (1S,3S)-ACPD
|
Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
|
[PMID: 9301676] |
In Vitro
cis-ACPD is a selective group II mGluR agonist, with EC50s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively[2].
cis-ACPD (1-1000 µM; 60 min) stimulates hydrolysis of 3H-phosphoinositide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 477331-06-9
-
Peso molecular 173.17
-
Fòrmula C7H11NO4
-
SMILES
O=C([C@]1(N)C[C@H](C(O)=O)CC1)O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56(5):1789-96. [Content Brief]
[2]. Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57(11): 889-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cis-ACPD Related Classifications
HY-19434A Related Classifications
Powered by Bioz