CW 008
Based on 2 publication(s) in Google Scholar
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.15%
- No. CAS: 1134613-19-6
- Fòrmula: C21H14F2N6O2
- Peso molecular:420.37
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Epigenetics Compound Library
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Stem Cell Signaling Compound Library
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TGF-beta/Smad Compound Library
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Osteogenesis Compound Library
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Publications Citing Use of MedChemExpress (MCE) CW 008
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Actividad biológica
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PKA |
Chemical Information
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No. CAS 1134613-19-6
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Appearance Solid
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Peso molecular 420.37
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Fòrmula C21H14F2N6O2
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Color White to yellow
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SMILES
O=C(C1=CC=C(C=C1)F)NC2=NNC3=C2C=C(F)C(C4=C5C=C(OC)C=CN5N=C4)=N3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Metab
Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis. [Abstract]2026 Feb 3;38(2):370-387.e10. PMID: 41638192 -
Mol Carcinog
Adipocytes Promote Endometrial Cancer Progression Through Activation of the SIRT1-HMMR Signaling Axis. [Abstract]2024 Dec;63(12):2363-2381. PMID: 39254492
Solvente y solubilidad
DMSO : 16.67 mg/mL (39.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3789 mL | 11.8943 mL | 23.7886 mL | 59.4714 mL |
| 5 mM | 0.4758 mL | 2.3789 mL | 4.7577 mL | 11.8943 mL | |
| 10 mM | 0.2379 mL | 1.1894 mL | 2.3789 mL | 5.9471 mL | |
| 15 mM | 0.1586 mL | 0.7930 mL | 1.5859 mL | 3.9648 mL | |
| 20 mM | 0.1189 mL | 0.5947 mL | 1.1894 mL | 2.9736 mL | |
| 25 mM | 0.0952 mL | 0.4758 mL | 0.9515 mL | 2.3789 mL | |
| 30 mM | 0.0793 mL | 0.3965 mL | 0.7930 mL | 1.9824 mL |
CW 008 Related Classifications
HY-110218 Related Classifications
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