FL113
FL113 is a racemate of FL118 (HY-12486). FL113 is less effective than FL118 in inhibiting the expression of Survivin, Mcl-1, XIAP, and cIAP2. FL113 exhibits weaker antitumor activity than FL118 in colon tumor xenograft models. FL113 can be used for research on colon cancer and head and neck cancer.
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- No. CAS: 104155-89-7
- Fòrmula: C21H16N2O6
- Peso molecular:392.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Mcl-1 |
XIAP |
cIAP2 |
In Vitro
FL113 (10 nM; 48-96 h) is far less effective than FL118 (HY-12486) in inhibiting the expression of survivin, Mcl-1, XIAP, and cIAP2 in head and neck FaDu cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FaDu
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Concentration:10 nM
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Incubation Time:48, 72, and 96 h
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Result:Inhibited survivin, Mcl-1, XIAP, and cIAP2 protein expression less effectively than FL118.
In Vivo
FL113 (1 mg/kg; weekly × 4 schedule) exhibits much weaker antitumor activity than FL118 in colon tumor xenograft models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice (female, 6-12 weeks old)[1]
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Dosage:1.5 mg/kg
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Administration:i.p.; single injection
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Result:Resulted in less effective inhibition of survivin, Mcl-1, and cIAP2 expression compared to FL118.
Showed no inhibitory effect on XIAP in the in vivo tumor tissues.
Chemical Information
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No. CAS 104155-89-7
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Peso molecular 392.37
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Fòrmula C21H16N2O6
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SMILES
O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=C6OCOC6=CC5=CC4C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FL113 Related Classifications
HY-187844 Related Classifications
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