Eed - embryonic ectoderm development Gene

Also Known as lusk; l7Rn5; l(7)5Rn

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13626

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of adaxial/abaxial pattern formation; and regulation of gene expression. Located in pronucleus and sex chromatin. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including branchial arch; early embryo; extraembryonic component; genitourinary system; and nervous system. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Apr 2022]

Eed Products (1)

mRNA Protein Name
NM_021876.3 NP_068676.1 polycomb protein EED

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16687444 MGI
enables enzyme activator activity IMP
IMP: Inferred from mutant phenotype
15916951 MGI
enables methylated histone binding IDA
IDA: Inferred from direct assay
17107999 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9584197 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in facultative heterochromatin formation IDA
IDA: Inferred from direct assay
20064375 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
12627233 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17107999 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24105743 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
28041882 MGI
acts upstream of or within regulation of adaxial/abaxial pattern formation IGI
IGI: Inferred from genetic interaction
17107999 MGI
Cellular Component GO Annotation Evidence Referencias Source
part of ESC/E(Z) complex IDA
IDA: Inferred from direct assay
20064375 MGI
part of chromatin silencing complex IDA
IDA: Inferred from direct assay
26658965 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9584197 MGI
located in pronucleus IDA
IDA: Inferred from direct assay
12900441 MGI
located in sex chromatin IDA
IDA: Inferred from direct assay
15525528 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polycomb protein EED

  • lethal, Chr 7, Rinchik 5

Eed Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
Eed Q921E6 Ezh2 Mus musculus Q61188-1
X-Ray Diffraction
17937919
Intra
Eed Q921E6 Ezh2 Mus musculus Q61188-1
GMS
17937919
Intra
Eed Q921E6 Jarid2 Mus musculus Q62315
Density Sedimentation
20064375
Intra
Eed Q921E6 Jarid2 Mus musculus Q62315
Anti Tag CoIP
20064376
Intra
Eed Q921E6 Jarid2 Mus musculus Q62315
GMS
20075857
Intra
Eed Q921E6 Jarid2 Mus musculus Q62315
Anti Tag CoIP
20064375
Intra
Eed Q921E6 Ezh2 Mus musculus Q61188
CoIP
9742080
Intra
Eed Q921E6 Ezh2 Mus musculus Q61188
Density Sedimentation
20064375
Intra
Eed Q921E6 Ezh2 Mus musculus Q61188
Anti Tag CoIP
20064376
Intra
Eed Q921E6 Ezh2 Mus musculus Q61188
IF
12900441
Intra
Eed Q921E6 Ezh2 Mus musculus Q61188
Anti Tag CoIP
20064375
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-139400A Pociredir hydrochloride Inhibitor 99.89% Phase 2
HY-158102 Rinzimetostat Inhibitor 99.90% Phase 1
HY-103663 MAK683 Inhibitor 99.02% Phase 1
HY-132922 EEDi-5273 Inhibitor 99.48% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-101117 EED226 Inhibitor 99.56% Unkown
HY-130708 UNC6852 Inhibitor 98.49% Unkown
HY-101512 A-395 Inhibitor 99.12% Unkown
HY-139400 Pociredir Inhibitor 99.97% Unkown
HY-148334 MS8815 Degrader 99.95% Unkown
HY-W004697 Boc-GABA-OH 99.14% Unkown
HY-W014099 Boc-NH-C4-acid 99.65% Unkown
HY-130615 PROTAC EED degrader-2 Inhibitor 99.90% Unkown
HY-130979 EED226-COOH Degrader 99.88% Unkown
HY-130815A MAK683-C2-acid hydrochloride Inhibitor 99.60% Unkown
HY-136977 EEDi-5285 Inhibitor 99.87% Unkown
HY-160924 MS147 Degrader 98.31% Unkown
HY-130614 PROTAC EED degrader-1 Inhibitor 99.18% Unkown
HY-158239 MS181 98.36% Unkown
HY-135045 (S,R,S)-AHPC-C4-COOH 95.92% Unkown
HY-158102A Rinzimetostat TFA 99.82% Unkown
HY-132970 EED ligand 1 Inhibitor 99.93% Unkown
HY-130815 MAK683-CH2CH2COOH Inhibitor / Unkown
HY-114176B (S,R,S)-AHPC-C4-NH2 dihydrochloride / Unkown
HY-130816 (S,R,S)-AHPC-O-Ph-PEG1-NH2 96.97% Unkown
HY-114176 (S,R,S)-AHPC-C4-NH2 hydrochloride 99.69% Unkown
HY-P2266 SAH-EZH2 Inhibitor 99.50% Unkown
HY-RS04173 EED Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103663A MAK683 hydrochloride Inhibitor / Unkown
HY-130711A (S,R,S)-AHPC-C3-NH2 TFA / Unkown
HY-114176A (S,R,S)-AHPC-C4-NH2 / Unkown
HY-130638 (S,R,S)-AHPC-O-Ph-PEG1-NH-Boc / Unkown
HY-130711 (S,R,S)-AHPC-C3-NH2 / Unkown
HY-101512D rel-A-395 hydrochloride Inhibitor / Unkown
HY-130637 Boc-NH-PEG1-Ph-O-CH2COOH / Unkown
HY-130711C (S,R,S)-AHPC-C3-NH2 dihydrochloride 95.0% Unkown
HY-148641 ZJH-16 Inhibitor / Unkown
HY-168131 PROTAC EZH2 Degrader-3 / Unkown
HY-174372 EZH2-IN-23 Inhibitor / Unkown
HY-174397 EED-IN-3 Inhibitor / Unkown
HY-178694 DC-PRC2in-01 Inhibitor / Unkown
HY-181308 PROTAC EZH2 Degrader-13 Degrader / Unkown
HY-181320 PROTAC EZH2 Degrader-19 Degrader / Unkown
HY-181323 PROTAC EZH2 Degrader-22 Degrader / Unkown
HY-181392 PROTAC EZH2 Degrader-35 Degrader / Unkown
HY-181413 PROTAC EZH2 Degrader-44 / Unkown
HY-182365 EED-IN-4 Inhibitor / Unkown
HY-182366 EED-IN-5 Inhibitor / Unkown
HY-124660A A-395N / Unkown
HY-RS16662 Eed Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23097 Eed Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eed NCBI NCBI:8726