Glutarimide
Based on 1 Customer Validation
Glutarimide is a CRBN binder. Glutarimide exerts its function by binding to the thalidomide-binding domain of the CRBN protein. Glutarimide serves as an important structural component of many biologically active compounds. Glutarimide can be used in studies related to anemia, multiple myeloma and cycloheximide.
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- Pureza : 98.0%
- No. CAS: 1121-89-7
- Fòrmula: C5H7NO2
- Peso molecular:113.11
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Almacenamiento:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Cereblon |
In Vitro
Glutarimide is the CRBN-binding motif that mediates the interaction between CELMoD and the thalidomide-binding domain of CRBN[1].
Glutarimide does not inhibit carbachol (HY-B1208)-induced calcium mobilization in neuroblastoma SK-N-SH cells at concentrations up to 120 μM, with an IC50 > 120 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 1121-89-7
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Appearance Solid
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Peso molecular 113.11
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Fòrmula C5H7NO2
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Color White to off-white
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SMILES
O=C(CCC1)NC1=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (442.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Szewczyk SM, et al. Trends in Neosubstrate Degradation by Cereblon-Based Molecular Glues and the Development of Novel Multiparameter Optimization Scores. J Med Chem. 2024 Jan 25;67(2):1327-1335. [Content Brief]
[2]. Nakae K, et al. Migrastatin acts as a muscarinic acetylcholine receptor antagonist. The Journal of antibiotics. 2006 Nov;59(11):685-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.8410 mL | 44.2048 mL | 88.4095 mL | 221.0238 mL |
| 5 mM | 1.7682 mL | 8.8410 mL | 17.6819 mL | 44.2048 mL | |
| 10 mM | 0.8841 mL | 4.4205 mL | 8.8410 mL | 22.1024 mL | |
| 15 mM | 0.5894 mL | 2.9470 mL | 5.8940 mL | 14.7349 mL | |
| 20 mM | 0.4420 mL | 2.2102 mL | 4.4205 mL | 11.0512 mL | |
| 25 mM | 0.3536 mL | 1.7682 mL | 3.5364 mL | 8.8410 mL | |
| 30 mM | 0.2947 mL | 1.4735 mL | 2.9470 mL | 7.3675 mL | |
| 40 mM | 0.2210 mL | 1.1051 mL | 2.2102 mL | 5.5256 mL | |
| 50 mM | 0.1768 mL | 0.8841 mL | 1.7682 mL | 4.4205 mL | |
| 60 mM | 0.1473 mL | 0.7367 mL | 1.4735 mL | 3.6837 mL | |
| 80 mM | 0.1105 mL | 0.5526 mL | 1.1051 mL | 2.7628 mL | |
| 100 mM | 0.0884 mL | 0.4420 mL | 0.8841 mL | 2.2102 mL |
Glutarimide Related Classifications
HY-I0466 Related Classifications
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