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Referencia número: HY-143277

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HL-2

HL-2 is a ligand of the target protein PI3K kinase of HL-8 (HY-143275), which can be used for PROTAC synthesis.

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No. CAS: 2766352-49-0
Fòrmula: C₂₈H₁₈F₂N₆O₆S
Peso molecular:604.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

HL-2 Chemical Structure

No. CAS: 2766352-49-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information
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Actividad biológica

Descripciòn

HL-2 is a ligand of the target protein PI3K kinase of HL-8 (HY-143275), which can be used for PROTAC synthesis^[1].

IC₅₀ & Target

PI3Kα

Ver todos los productos específicos de isoformas PI3K :

Chemical Information

No. CAS 2766352-49-0
Peso molecular 604.54
Fòrmula C₂₈H₁₈F₂N₆O₆S
SMILES

COC1=NC=C(C=C1NS(=O)(C2=C(C=C(C=C2)F)F)=O)C3=CN4C(C5=NN=C(O5)C6=C(C=CC=C6)C(O)=O)=CN=C4C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang H, et al. Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase. Bioorg Med Chem. 2022;61:116707. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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HL-2

Ver todos los productos específicos de isoformas PI3K

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

HL-2 Related Classifications

HY-143277 Related Classifications