Hydroxymetronidazole
Based on 1 Customer Validation
Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.88%
- No. CAS: 4812-40-2
- Fòrmula: C6H9N3O4
- Peso molecular:187.16
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-136440R
Hydroxymetronidazole (Standard)Parasite Inhibitor -
HY-115249
Metronidazole acetic acidMetabolite -
HY-113468
3-O-Methyl-DL-DOPAEndogenous Metabolite -
HY-113468R
3-O-Methyl-DL-DOPA (Standard)Endogenous Metabolite -
HY-139167
7-HydroxywarfarinAnticoagulant Agent -
HY-W069721
N-Acetylsulfanilamide -
HY-W714137
(6-Isothiocyanatohexyl)(methyl)sulfaneIsothiocyanate -
HY-Z2337
Rabeprazole sulfoneImpurity reference -
HY-G0016
N-Acetyl dapsoneDapsone Metabolite -
HY-115249R
Metronidazole acetic acid (Standard)Antibiotic Agent -
HY-131527R
Wy-45494 hydrochloride (Standard) -
HY-131527
Wy-45494 hydrochloride
Ver todos los productos específicos de isoformas Parasite
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 4812-40-2
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Appearance Solid
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Peso molecular 187.16
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Fòrmula C6H9N3O4
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Color Off-white to light yellow
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SMILES
OCCN1C([N+]([O-])=O)=CN=C1CO
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Synonyms
Metronidazole-OH
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (534.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.36 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (284 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.3430 mL | 26.7151 mL | 53.4302 mL | 133.5755 mL |
| 5 mM | 1.0686 mL | 5.3430 mL | 10.6860 mL | 26.7151 mL | |
| 10 mM | 0.5343 mL | 2.6715 mL | 5.3430 mL | 13.3576 mL | |
| 15 mM | 0.3562 mL | 1.7810 mL | 3.5620 mL | 8.9050 mL | |
| 20 mM | 0.2672 mL | 1.3358 mL | 2.6715 mL | 6.6788 mL | |
| 25 mM | 0.2137 mL | 1.0686 mL | 2.1372 mL | 5.3430 mL | |
| 30 mM | 0.1781 mL | 0.8905 mL | 1.7810 mL | 4.4525 mL | |
| 40 mM | 0.1336 mL | 0.6679 mL | 1.3358 mL | 3.3394 mL | |
| 50 mM | 0.1069 mL | 0.5343 mL | 1.0686 mL | 2.6715 mL | |
| 60 mM | 0.0891 mL | 0.4453 mL | 0.8905 mL | 2.2263 mL | |
| 80 mM | 0.0668 mL | 0.3339 mL | 0.6679 mL | 1.6697 mL | |
| 100 mM | 0.0534 mL | 0.2672 mL | 0.5343 mL | 1.3358 mL |
Hydroxymetronidazole Related Classifications
HY-136440 Related Classifications
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