KCL-440
KCL-440 is a CNS-penetrated PARP inhibitor, with an IC50 of 68 nM. KCL-440 has strong inhibition of PARP-1.
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- No. CAS: 651029-09-3
- Fòrmula: C18H18N2O2
- Peso molecular:294.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 68 nM (PARP)[1].
In Vivo
KCL-440 (over 0.03 mg/kg/h) exhibits neuroprotective effects of KCL-440 in the in vivo cerebral ischemia model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat acute cerebral infarction model induced by photothrombotic MCA occlusion[1].
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Dosage:0.01, 0.03, 0.1, 0.3, 1.0, and 3.0 mg/kg/h.
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Administration:Intravenously administered at a rate of 0.33 ml/kg/h for 24 h immediately after cerebral ischemia.
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Result:The serum concentration of KCL-440 approached steadystate levels within 1 h in rats that were intravenously infused at the rate of 1 mg/kg/h for 6 h. One hour after the initiation of infusion, the serum concentration of KCL-440 is 0.11 μg/mL, which is equivalent to 0.37 μM. The brain:serum concentration ratio after a 6-h infusion at 10 mg/kg/h is 0.8.
Led to a dose-dependent reduction in the cerebral infarct size at 24 h after the MCA occlusion.
Chemical Information
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No. CAS 651029-09-3
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Peso molecular 294.35
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Fòrmula C18H18N2O2
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SMILES
O=C1NC=C(C2=CC=C(CN(C)C)C=C2)C3=C(O)C=CC=C31
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KCL-440 Related Classifications
HY-15050 Related Classifications
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