LEM-06
LEM-06 is an NSD2 inhibitor with a human IC50 of 890 μM and 0.8 mM. LEM-06 binds to the histone-tail binding groove of NSD2-SET, inhibiting NSD2-mediated H3K36 histone methyltransferase activity and H3K36 mono-methylation. LEM-06 serves as a hit molecule for further optimization or derivation to explore NSD2 biology. LEM-06 can be used for the research of multiple myeloma.
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- No. CAS: 1212675-57-4
- Fòrmula: C29H38N4O3
- Peso molecular:490.64
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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NSD2 890 μM (IC50) |
LEM-06 inhibits the H3K36 monomethylation activity of recombinant NSD2-SET protein in vitro, with an IC50 value of 890 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1212675-57-4
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Peso molecular 490.64
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Fòrmula C29H38N4O3
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SMILES
O=C1N2C([C@@]3([H])CN(C4CCN(CC4)C(C)=O)C[C@@](C3)([H])C2)=CC=C1C5=C(C=CC=C5)CN6CCOCC6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LEM-06 Related Classifications
HY-182486 Related Classifications
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