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United States

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Referencia número: HY-182486

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LEM-06

LEM-06 is an NSD2 inhibitor with a human IC₅₀ of 890 μM and 0.8 mM. LEM-06 binds to the histone-tail binding groove of NSD2-SET, inhibiting NSD2-mediated H3K36 histone methyltransferase activity and H3K36 mono-methylation. LEM-06 serves as a hit molecule for further optimization or derivation to explore NSD2 biology. LEM-06 can be used for the research of multiple myeloma.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 1212675-57-4
Fòrmula: C₂₉H₃₈N₄O₃
Peso molecular:490.64

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEM-06 Chemical Structure

No. CAS: 1212675-57-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocolo (1)
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

NSD2

890 μM (IC₅₀)

Ver todos los productos específicos de isoformas Histone Methyltransferase :

In Vitro

LEM-06 inhibits the H3K36 monomethylation activity of recombinant NSD2-SET protein in vitro, with an IC₅₀ value of 890 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

No. CAS 1212675-57-4
Peso molecular 490.64
Fòrmula C₂₉H₃₈N₄O₃
SMILES

O=C1N2C([C@@]3([H])CN(C4CCN(CC4)C(C)=O)C[C@@](C3)([H])C2)=CC=C1C5=C(C=CC=C5)CN6CCOCC6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocolo

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. di Luccio E, et al. Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies. J Cancer Prev. 2015;20(2):113-120. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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