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Referencia número: HY-P992517

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mDF6002

mDF6002 is a IL-12R-Fc fusion protein. mDF6002 induces sustained IFNγ production. mDF6002 exerts tumor-suppressive effects in mouse models of colon cancer and melanoma. mDF6002 can be used for research on solid tumors such as colon cancer and melanoma.

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Please store the product under the recommended conditions in the Certificate of Analysis.

mDF6002 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas CXCR :

Ver todos los productos específicos de isoformas TNF Receptor :

In Vitro

mDF6006 (0.006-6250 pM; 60 h) potently induces IFN-γ production in naive Balb/c mouse splenocytes with an EC₅₀ of 2.07 pM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	AUC_0-t	C_max	T_max	AUC
Mice^[1]	10 μg/mL	i.v.	29.85 h	5,637 ng·h/mL	258 ng/mL	0.19 h	/
Mice^[1]	10 μg/mL	s.c.	/	/	/	/	6.33 ng·h/mL

In Vivo

mDF6006 (1 μg; s.c.; once weekly; 7 weeks) achieves 100% complete tumor regression in advanced large CT26 colon carcinoma-bearing BALB/cJ mice and induces protective T cell memory in 90% of treated mice^[1].
mDF6006 (0.5 μg; i.p.; once weekly) induces partial responses in 90% of B16F10 melanoma-bearing C57BL/6J mice and drives sustained pharmacodynamic responses in both tumor and serum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/cJ mice (female, 7-9 weeks old, subcutaneous inoculation with CT26 cells, advanced large tumors averaging 815 mm³)^[1]
Dosage:

1 μg (equimolar to 1 μg rmIL-12)
Administration:

s.c.; once weekly; 7 weeks
Result:

Induced complete tumor regression in all 10 treated mice.
Was well tolerated with no body weight loss.
Enabled 9/10 complete responders to reject tumor rechallenge and remain tumor-free, while age-matched naive controls developed progressive tumors.

Animal Model:

C57BL/6J mice (female, 7-9 weeks old, subcutaneous inoculation with B16F10 cells)^[1]
Dosage:

0.5 μg (equimolar to 0.5 μg rmIL-12)
Administration:

i.p.; once weekly
Result:

Induced partial responses in 9/10 treated mice.
Significantly improved survival compared to rmIL-12.
Significantly elevated and protracted levels of IFNγ, CXCL9, CXCL10, CCL5, and TNF-α were detected in both tumor lysates and serum at 72 hours post-dose.

Chemical Information

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Gutierrez E, et al. An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses. Med. 2023 May 12;4(5):326-340.e5. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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mDF6002

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Ver todos los productos específicos de isoformas CXCR

Ver todos los productos específicos de isoformas TNF Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

mDF6002 Related Classifications

HY-P992517 Related Classifications