Naftazone
Based on 1 publication(s) in Google Scholar
Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation.
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- Pureza: 99.93%
- No. CAS: 15687-37-3
- Fòrmula: C11H9N3O2
- Peso molecular:215.21
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Publications Citing Use of MedChemExpress (MCE) Naftazone
MoreVer todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
Naftazone (0.5-50 μM; 1 h) reduces glutamate release from mouse cerebellum synaptosomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male rats[1]
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Dosage:10 and 100 mg/kg
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Administration:Oral gavage; 10 and 100 mg/kg once per day; for 15 days
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Result:Significantly reduced glutamate content in cerebro spinal fluid of rats.
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Animal Model:Wistar rats[2]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection ; 50 mg/kg once daily for 5 days
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Result:Reduced the height of platelet aggregation induced by ADP, significantly increased the platelet disaggregation induced by collagen and reduced fibrinogen binding to 2.5 or 5 μM ADP-stimulated platelet.
Chemical Information
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No. CAS 15687-37-3
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Appearance Solid
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Peso molecular 215.21
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Fòrmula C11H9N3O2
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Color Yellow to orange
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SMILES
O=C1C2=CC=CC=C2C=C/C1=N\NC(N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Theranostics
2025 Jan 1;15(2):745-765. PMID: 39744686
Solvente y solubilidad
DMSO : 100 mg/mL (464.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Mattei C, et al. Naftazone reduces glutamate cerebro spinal fluid levels in rats and glutamate release from mouse cerebellum synaptosomes. Neurosci Lett. 1999 Aug 27;271(3):183-6. [Content Brief]
[2]. McGregor L, et al. Effect of naftazone on in vivo platelet function in the rat. Platelets. 1999;10(1):66-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6466 mL | 23.2331 mL | 46.4662 mL | 116.1656 mL |
| 5 mM | 0.9293 mL | 4.6466 mL | 9.2932 mL | 23.2331 mL | |
| 10 mM | 0.4647 mL | 2.3233 mL | 4.6466 mL | 11.6166 mL | |
| 15 mM | 0.3098 mL | 1.5489 mL | 3.0977 mL | 7.7444 mL | |
| 20 mM | 0.2323 mL | 1.1617 mL | 2.3233 mL | 5.8083 mL | |
| 25 mM | 0.1859 mL | 0.9293 mL | 1.8586 mL | 4.6466 mL | |
| 30 mM | 0.1549 mL | 0.7744 mL | 1.5489 mL | 3.8722 mL | |
| 40 mM | 0.1162 mL | 0.5808 mL | 1.1617 mL | 2.9041 mL | |
| 50 mM | 0.0929 mL | 0.4647 mL | 0.9293 mL | 2.3233 mL | |
| 60 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9361 mL | |
| 80 mM | 0.0581 mL | 0.2904 mL | 0.5808 mL | 1.4521 mL | |
| 100 mM | 0.0465 mL | 0.2323 mL | 0.4647 mL | 1.1617 mL |
Naftazone Related Classifications
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