NB-216
NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM). NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM). NB-216 can be used for the study of Alzheimer's disease.
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- No. CAS: 943924-04-7
- Fòrmula: C35H45N3O4
- Peso molecular:571.75
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Cathepsin
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Actividad biológica
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BACE1 17 nM (IC50) |
Cathepsin D 1 nM (IC50) |
Cathepsin E 0.4 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
20 nM
Compound: 3, NB-216
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Inhibition of BACE1 expressed in APP-overexpressing CHO cells
Inhibition of BACE1 expressed in APP-overexpressing CHO cells
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[PMID: 19963375] |
NB-216 (Compound 3) exhibits good passive permeability and low P-gP-mediated efflux, suggesting its potential to improve brain permeability in Madin-Darby canine kidney cells overexpressing the human form of P-glycoprotein (MDR1-MDCK)[1].
NB-216 exhibits an IC50 value of 20 nM in CHO cells overexpressing human amyloid precursor protein (APP)sup>[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 943924-04-7
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Peso molecular 571.75
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Fòrmula C35H45N3O4
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SMILES
O=C(N[C@H]([C@H](O)CNC1(C2=CC=CC(C(C)C)=C2)CC1)CC3=CC=CC(OCCCCN4)=C3)C5=CC4=CC(COC)=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NB-216 Related Classifications
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